Androgen receptor activity in human breast cancer and its relationship with oestrogen and progestogen receptor activity
Abstract
Androgen receptor activity was measured in tumours from 122 patients with breast cancer. Forty-two tumours (34%) possessed androgen receptors at levels varying from 17 to 210 fmol/mg cytosol protein (mean value 68). No relationship was detected between androgen receptors and menopausal status of the patients and whether or not lymph nodes were invaded with tumour at the time of biopsy. There were, however, significant positive correlations between the presence of androgen receptors and that of oestrogen (P less than 0.05) and of progestogen receptors (P less than 0.025). These relationships suggest that androgen receptors may be of value in predicting the hormone responsiveness of breast tumours but definitive proof of this requires clinical follow-up of the patients studied.
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In primary breast cancer, AR has been found in 54% of premenopausal and 48% of postmenopausal patients.
“In fact, in primary breast cancer, AR has been found in 54% of premenopausal and 48% of postmenopausal patients (180,182).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [180]
The role of androgens as direct inhibitors of breast cancer growth is well supported by the presence of AR in a large proportion of human breast cancers.
“The role of androgens as direct inhibitors of breast cancer growth is well supported by the presence of AR in a large proportion of human breast cancers (178 -181).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [180]
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- Authors
- Miller, W. R., Telford, J., Dixon, J. M., & Hawkins, R. A.
- Affiliations
- Edinburgh Royal Infirmary (GB)
- Venue
- European Journal of Cancer and Clinical Oncology
- Publisher
- Elsevier BV
- Published
- 1985-04
- Volume
- 21
- Issue
- 4
- Pages
- 539-542
- ISSN
- 0277-5379 (ISSN-L)
- OpenAlex
- W1986226520
- Cited by
- 46
- References
- 18
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer and Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- androgen receptor, breast cancer, oestrogen receptor, progestogen receptor, hormone responsiveness, menopausal status, lymph node metastasis
- MeSH terms
- Breast Neoplasms, Female, Humans, Lymphatic Metastasis, Menopause, Neoplasm Recurrence, Local, Receptors, Androgen, Receptors, Estrogen, Receptors, Progesterone, Receptors, Steroid
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