Growth inhibition of 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors by controlled-release low-dose medroxyprogesterone acetate.
Abstract
Since our previous findings had indicated that the androgenic steroid medroxyprogesterone acetate (MPA) exerts potent inhibitory effects on 7,12-dimethylbenz(a)anthracene (DMBA)-induced tumor growth, we have studied the effect of low doses of MPA released from Depo-Provera and from 50:50 poly[DL-lactide-co-glycolide] microspheres in the same DMBA-induced tumor model. The present data show that single subcutaneous injection of a 4-month controlled-release formulation of biodegradable 50:50 poly[DL-lactide-co-glycolide] microspheres containing 10 mg of MPA giving serum levels of 3.14 +/- 0.32 ng/ml (8.12 +/- 0.83 nM) MPA causes a maximal or near-maximal 60% inhibition of tumor growth measured 56 days later. Such data suggest that controlled-release formulations giving constant and low blood levels of MPA could be used for the treatment of breast cancer in women. Such a low concentration of MPA should avoid the side effects observed with the high doses of the compound.
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Controlled release of low-dose MPA exerts a potent inhibitory effect on development and growth of DMBA-induced mammary carcinoma in the rat.
“in vivo studies have demonstrated that controlled release of low-dose MPA, a compound having androgenic activity, also exerts a potent inhibitory effect on the development and growth of DMBA-induced mammary carcinoma in the rat (243, 244).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [243]
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Self-citation
- Authors
- Li, S., Lepage, M., Mérand, Y., Bélanger, A., & Labrie, F.
- Affiliations
- Université Laval (CA)
- Centre hospitalier de l'Université Laval (CA)
- ORCID
- Lepage, Martin
- Venue
- Breast Cancer Research and Treatment
- Published
- 1992-06
- Volume
- 24
- Issue
- 2
- Pages
- 127-137
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2052146398
- Cited by
- 14
- References
- 46
- Citations by year
- 2012: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Breast Cancer Research and Treatment (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- medroxyprogesterone acetate, 7,12-dimethylbenz(a)anthracene, DMBA-induced mammary tumors, controlled drug delivery, tumor growth inhibition, androgenic steroids, breast cancer treatment, low-dose hormone therapy
- MeSH terms
- Animals, Carcinoma, Delayed-Action Preparations, Female, Follicle Stimulating Hormone, Injections, Subcutaneous, Luteinizing Hormone, Mammary Neoplasms, Experimental, Microspheres, 9,10-Dimethyl-1,2-benzanthracene, Rats, Sprague-Dawley, Medroxyprogesterone Acetate, Rats
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