Fluid consumption in water-deprived rats after administration of naloxone or quaternary naloxone
Abstract
Water-deprived male rats were given access to water, or to a 0.005M sodium saccharin solution, or to a 0.9% sodium chloride solution, during a 30 min test period. Naloxone (0.01-10.0 mg/kg) produced dose-dependent reductions in the consumption of each fluid. Saccharin-drinking was significantly reduced by 0.01 mg/kg naloxone, and water- and saline-drinking by 0.1 mg/kg naloxone. Quaternary naloxone (0.01-10.0 mg/kg) had no effect on drinking under any condition. Access to the saline solution resulted in hyperdipsia, due to a prolongation of the initial bout of avid drinking in the thirsty rats. Naloxone, in small doses, completely abolished this hyperdipsia. Since the quaternary compound had no effect, it was concluded that opiate antagonist suppression of saline-induced hyperdipsia was probably mediated at central opiate receptors.
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The endogenous opiate system modulates the rewarding and reinforcing effects of food, water, sex, intracranial self-stimulation, and other rewards.
“The endogenous opiate system is well-known to modulate, in part, the rewarding and reinforcing effects of food, water, sex, intracranial self-stimulation, and other rewards (Broekkamp and Phillips 1979; Turkish and Cooper 1983; West et al 1983; Agmo and Berenfeld 1990; Yeomans and Gray 1996; Gerrits et al 2003).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Turkish and Cooper 1983
Cites
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Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“The endogenous opiate system is well-known to modulate, in part, the rewarding and reinforcing effects of food, water, sex, intracranial self-stimulation, and other rewards (Broekkamp and Phillips 1979; Turkish and Cooper 1983; West et al. 1983; Agmo and Berenfeld 1990; Yeomans and Gray 1996; Gerrits et al. 2003).”
Burkett, J. P., Spiegel, L. L., Inoue, K., Murphy, A. Z., & Young, L. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.117 · Cited by 133 · see citing works
Feed-forward mechanisms: Addiction-like behavioral and molecular adaptations in overeating
Alsiö, J., Olszewski, P. K., Levine, A. S., & Schiöth, H. B. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.01.002 · Cited by 81 · see citing works
- Authors
- Turkish, S., & Cooper, S. J.
- Affiliations
- University of Birmingham (GB)
- ORCID
- Cooper, Steven J.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 7
- Issue
- 4-6
- Pages
- 835-839
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2092699020
- Cited by
- 6
- References
- 11
- Citations by year
- 2013: 1 · 2012: 2
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- naloxone, opioid antagonists, water deprivation, hyperdipsia, water intake
- MeSH terms
- Animals, Hydromorphone, Drinking, Male, Muridae, Naloxone, Oxymorphone, Receptors, Opioid, Taste, Thirst, Water Deprivation
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