Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles
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Despite significant evidence that opioids are involved in attachment by mediating social reward and motivation, the role of opioids in the formation of adult social attachments has not been explored. We used the socially monogamous prairie vole (Microtus ochrogaster) to explore the role of endogenous opioids in social bonding by examining partner preference formation in female prairie voles. We hypothesized that μ-opioid receptors (MORs) in the striatum have a critical role in partner preference formation. We therefore predicted that peripheral administration of an opioid receptor antagonist would inhibit partner preference formation, and more specifically, that μ-opioid selective receptor blockade within the striatum would inhibit partner preference formation. To test our hypotheses, we first administered the non-selective opioid antagonist naltrexone peripherally to females during an 18-h cohabitation with a male and later tested the female with a partner preference test (PPT). Females showed a dose schedule-dependent decrease in partner preference in the PPT, with females in the continuous dose group displaying stranger preferences. Next, we administered microinjections of the MOR selective antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) into either the nucleus accumbens shell (NAS) or the caudate-putamen (CP) immediately before a 24-h cohabitation with a male, and later tested the female with a PPT. Females receiving CTAP into the CP, but not the NAS, showed no preference in the PPT, indicating an inhibition of partner preference formation. We show here for the first time that MORs modulate partner preference formation in female prairie voles by acting in the CP.
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In prairie voles, a peripherally administered non-selective opioid antagonist prevents pair bond formation but also reduces mating.
“In this species, a peripherally administered, non-selective opioid antagonist prevents pair bond formation between prairie voles, but also reduces mating (Burkett et al 2011).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Burkett et al 2011
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- Authors
- Burkett, J. P., Spiegel, L. L., Inoue, K., Murphy, A. Z., & Young, L. J.
- Affiliations
- Emory University (US)
- Georgia State University (US)
- Corresponding author
- Young, Larry J
- Venue
- Neuropsychopharmacology
- Published
- 2011-07-06
- Volume
- 36
- Issue
- 11
- Pages
- 2200-2210
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3176565
- OpenAlex
- W2140104467
- Cited by
- 133
- References
- 87
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 18 · 2015: 11 · 2014: 9 · 2013: 15 · 2012: 7
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (P51OD011132)
- U.S. Public Health Service (077776)
- Yerkes National Primate Research Center, Emory University
- National Institute of Mental Health (MH-64692, K02MH064692)
- National Center for Research Resources (RR-0165, P51RR000165)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- mu-opioid receptor, Microtus ochrogaster, social attachment, mate preferences, dorsal striatum, caudate-putamen, nucleus accumbens shell, naltrexone, CTAP, opioid antagonists, social bonding, monogamy
- MeSH terms
- Age Factors, Animals, Corpus Striatum, Arvicolinae, Female, Male, Microinjections, Naltrexone, Pair Bond, Sexual Behavior, Animal, Social Behavior, Receptors, Opioid, mu, Opioid Peptides
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