Myeloperoxidase as a Biomarker of Skin Irritation and Inflammation
Abstract
Topical exposure to many occupational and environmental chemicals is often accompanied by the induction of a cutaneous inflammatory response characterized by the influx of polymorphonuclear leucocytes (PMNs). In this study, the accumulation of myeloperoxidase (MPO), an enzyme found at high content in PMNs, was used as a biomarker to assess the inflammatory response to a number of well characterized skin irritants and tumour promoters. Of the chemicals examined, there was a good agreement between MPO accumulation and morphometric indicators of PMNs. Therefore, it was suggested that MPO accumulation could be an additional and useful toxicological tool for determining the dermal irritancy of chemicals.
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The MPO system has been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis.
“beyond a role in cutaneous innate immunity, the MPO system has also been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis (51–59).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [51]
Indiscriminate HOCl-dependent induction of chlorination stress might be associated with adverse irritant effects.
“Also, in the context of balancing HOCl-related organ toxicity and therapeutic effects, it should be mentioned that the indiscriminate HOCl-dependent induction of chlorination stress might be associated with adverse irritant effects (51, 141–144).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [51]
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- Authors
- Trush, M. A., Egner, P. A., & Kensler, T. W.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Trush, M.A.
- ORCID
- Kensler, T.W.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 1994-02
- Volume
- 32
- Issue
- 2
- Pages
- 143-147
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W1976563047
- Cited by
- 146
- References
- 32
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01es005131-03, 5r01es003760-16, 5p01ca044530-13)
- National Cancer Institute (CA 44530)
- National Institute of Environmental Health Sciences (ES 05131, ES03760)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- myeloperoxidase, biomarkers, skin irritation, skin inflammation, polymorphonuclear leukocytes, tumor promoters, occupational chemicals, environmental chemicals, leukocyte accumulation
- MeSH terms
- Animals, Carcinogens, Drug Eruptions, Female, Peroxidase, Neutrophils, Skin, Tetradecanoylphorbol Acetate, Biomarkers, Mice
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