Impaired healing of nitrogen mustard wounds in CXCR2 null mice
Open accessAbstract
To examine the significance of chemokine activation of CXCR2 in wound healing after chemical burn, cutaneous injury was created by topical application of nitrogen mustard on CXCR2 wild type (+/+), heterozygous (+/–), and knockout (–/–) mice. Wounds were analyzed histologically for neutrophil and monocyte infiltration and for reepithelialization at postwound days 4, 7, and 10. Neutrophil recruitment to the wound site was reduced through postwound day 7 in CXCR2 –/– mice as indicated by myeloperoxidase assay and by visual quantitation. Because there is always concern that mice with targeted deletion of a specific receptor may undergo developmental adaptations to offset the loss of the receptor, we also accessed chemical wound repair in the presence of a small molecule antagonist of CXCR2. Dietary supplementation with a CXCR2 antagonist (SB‐265610) during the wound repair process also markedly delayed healing parameters in CXCR2 +/+ mice, even greater than treatment with glucocorticoids. These parallel studies further establish that mice deficient in CXCR2 function exhibit delayed cutaneous wound healing that may be primarily linked to impaired neutrophil recruitment after chemical burn with nitrogen mustard. Thus, there may be a potential therapeutic benefit of treating nitrogen mustard‐induced skin lesions with agonists of CXCR2 to facilitate the wound repair process. (WOUND REP REG 2003;11:213–219)
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CXCR2−/− mice display impaired neutrophil recruitment and delayed wound healing.
“CXCR2−/− mice display impaired neutrophil recruitment and delayed wound healing.47,48”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [48]
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- Authors
- Milatovic, S., Nanney, L. B., Yu, Y., White, J. R., & Richmond, A.
- Affiliations
- Vanderbilt University (US)
- Centre for Cancer Biology (AU)
- GlaxoSmithKline (United States) (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Richmond, Ann
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2003-05
- Volume
- 11
- Issue
- 3
- Pages
- 213-219
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- PMC
- PMC2667443
- OpenAlex
- W2035570125
- Cited by
- 55
- References
- 19
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 3
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Wound Repair and Regeneration (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK6 BX005225)
- National Cancer Institute (R01CA034590)
- National Institute of General Medical Sciences (GM 40437, R01GM040437)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR041943, P30-AR41943)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Keywords
- CXCR2, wound healing, nitrogen mustard, skin wounds, neutrophil recruitment, chemokines, CXCR2 antagonist, re-epithelialization, chemical burns, glucocorticoids
- MeSH terms
- Animals, Burns, Chemical, Mechlorethamine, Mice, Inbred BALB C, Peroxidase, Neutrophils, Prednisolone, Time Factors, Wound Healing, Wounds and Injuries, Polymerase Chain Reaction, Mice, Knockout, Receptors, Chemokine, Receptors, Interleukin-8B, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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