Cited by 258Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsHormonal and reproductive studies

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues.

Simard, J., Luthy, I., Guay, J., Bélanger, A., Labrie, F.·1986·Molecular and Cellular Endocrinology

Open this paper in CoChat — free account

Abstract

In rat adenohypophysial cells in primary culture, the specific uptake of [3H] testosterone (T) is completely blocked by increasing concentrations of the pure antiandrogen flutamide-OH, the active metabolite of flutamide at an IC50 value of 50 nM while unlabeled T causes a similar inhibition at an IC50 value of 0.5 nM. After 210 min of incubation of 3 nM [3H]T with the anterior pituitary cells, 80% of radioactivity is still present as unchanged T. Direct binding studies show that flutamide-OH and flutamide interact with the rat anterior pituitary androgen receptor at Ki values of 55 and 1275 nM, respectively. In rat ventral prostate (cytosolic and nuclear fractions) and cytosol from human prostatic carcinoma, rat uterus and mouse Shionogi mammary carcinoma, the Ki values ranged from 0.1 to 0.47, 0.6 to 2.7, 62 to 205 and 1450 to 7550 nM for dihydrotestosterone, T, flutamide-OH and flutamide, respectively . Since the ability of flutamide-OH to inhibit the uptake of [3H]T in intact adenohypophysial cells and to compete for binding to the adenohypophysial androgen receptor shows almost identical values at approximately 1% of the potency of T itself, it is most likely that the antiandrogen activity of flutamide-OH can be completely explained by the ability of the pure antiandrogen to displace androgen from their specific receptor in target tissues. In addition, the finding of similar binding characteristics in a series of other tissues suggests that a similar potency of the antiandrogen can be expected in the other androgen-target tissues.

Integrity signals

Registry

Crossref · 10.1016/0303-7207(86)90132-2

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
Extension of Multiple Range Tests to Group Means with Unequal Numbers of Replications
Kramer, C. Y. (1956) · Biometrics · doi:10.2307/3001469 · Cited by 3,146
Important Advances in Oncology: 1986
Merrill, J. M. (1986) · JAMA · doi:10.1001/jama.1986.03380040106043 · Cited by 909
A Biological Profile of a Nonsteroidal Antiandrogen, SCH 13521 (4'–Nitro–3'–Trifluoromethylisobutyranilide)1
NERI, R. O., FLORANCE, K., Koziol, P., & CLEAVE, S. V. (1972) · Endocrinology · doi:10.1210/endo-91-2-427 · Cited by 326
A SOLUBLE ANDROGEN RECEPTOR IN THE CYTOPLASM OF RAT PROSTATE
Mainwaring, W. I. P. (1969) · Journal of Endocrinology · doi:10.1677/joe.0.0450531 · Cited by 292
Selective Effect of Androgens on LH and FSH Release in Anterior Pituitary Cells in Culture
Drouin, J., & Labrie, F. (1976) · Endocrinology · doi:10.1210/endo-98-6-1528 · Cited by 255
Self-citation
A prostatic cytosol receptor
Baulieu, É.-É., & Jung, I. (1970) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(70)90623-6 · Cited by 179
On the Mechanism of the Anti-androgenic Action ofFlutamide (α-α-α-Trifluoro-2-methyl-4'-nitro-m-propionotoluidide)in the Rat
Peets, E. A., HENSON, M. F., & NERI, R. O. (1974) · Endocrinology · doi:10.1210/endo-94-2-532 · Cited by 163
THE BINDING OF [1,2-3H]TESTOSTERONE WITHIN NUCLEI OF THE RAT PROSTATE
Mainwaring, W. I. P. (1969) · Journal of Endocrinology · doi:10.1677/joe.0.0440323 · Cited by 137
Action of a Nonsteroidal Antiandrogen, Flutamide, on the Receptor Binding and Nuclear Retention of 5α-Dihydrotestosterone in Rat Ventral Prostate1
Liao, S., HOWELL, D. K., & Chang, T. H. (1974) · Endocrinology · doi:10.1210/endo-94-4-1205 · Cited by 135

Show all 33 references

Research works printed but not linked: 6

Asselin, 1980, Cancer Res., 40, 1612
Fang, 1969, Mol. Pharmacol., 5, 428
Labrie, 1986, Prostate
Labrie, 1982, J. Clin. Invest. Med., 5, 267
Labrie, 1985, J. Steroid Biochem.
Neumann, 1970, Recent Progr. Horm. Res., 26, 337

Sorted by citations

Items 101–200 of 258

The effect of ketoconazole related imidazole drugs and antiandrogens on [3H] R1881 binding to the prostatic androgen receptor and [3H]5α-dihydrotestosterone and [3H]cortisol binding to plasma proteins
Ayub, M., & LEVELL, M. J. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90301-4 · Cited by 35
ANDROGEN-INDUCED CELL GROWTH ANDC-MYCEXPRESSION IN HUMAN NON-TRANSFORMED EPITHELIAL PROSTATIC CELLS IN PRIMARY CULTURE
Brum, I. S., Morsch, D. M., Urnauer, L., & Spritzer, P. M. (2001) · Endocrine Research · doi:10.1081/erc-100107177 · Cited by 35
Homologous Androgen Receptor Up-Regulation in Osteoblastic Cells May Be Associated with Enhanced Functional Androgen Responsiveness
Wiren, K. M., Keenan, E. J., Zhang, X., Ramsey, B., & ORWOLL, E. S. (1999) · Endocrinology · doi:10.1210/endo.140.7.6753 · Cited by 35
Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome: a randomized prospective study
Şahin, İ., Serter, R., Karakurt, F., Demirbas, B. T., Çulha, C., Taşkapan, Ç., Koşar, F., & Aral, Y. (2004) · Gynecological Endocrinology · doi:10.1080/09513590400004736 · Cited by 34
Characteristics of flutamide action on prostatic and testicular functions in the rat
Marchetti, B., & Labrie, F. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90170-7 · Cited by 34
Self-citation
5-En-androstene-3 β,17 β-diol inhibits the growth of MCF-7 breast cancer cells when oestrogen receptors are blocked by oestradiol
Boccuzzi, G., Brignardello, E., Monaco, M. D., Gatto, V., Leonardi, L., Pizzini, A., & Gallo, M. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.444 · Cited by 34
Evaluation and Treatment of Hirsutism in Premenopausal Women
Mimoto, M. S., Oyler, J. L., & Davis, A. M. (2018) · JAMA · doi:10.1001/jama.2018.2611 · Cited by 31
Effects of the commercial antiandrogen flutamide on the biomarkers of reproduction in male Murray rainbowfish (Melanotaenia fluviatilis)
Bhatia, H., Kumar, A., Ogino, Y., Du, J. C., Gregg, A. L., Chapman, J. C., McLaughlin, M. J., & Iguchi, T. (2014) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2524 · Cited by 31
Conniving for the first time of BiVO4 – rGO/CE-BN and its potential as enhanced electrochemical sensing of non-steroidal anti-androgen drug
Bhuvaneswari, C., Palpandi, K., Amritha, B., Paunkumar, P., Priya, R. L., Raman, N., & Babu, S. G. (2022) · Microchemical Journal · doi:10.1016/j.microc.2022.108174 · Cited by 31
Androgen Receptor Blockade in Experimental Combination Therapy of Pancreatic Cancer
Konduri, S., Schwarz, M. A., Cafasso, D. E., & Schwarz, R. E. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.09.034 · Cited by 31
Polycystic ovary syndrome and acne.
Chuan, S. S., & Rj, C. (2010) · PubMed · Cited by 31
Retrospective observational study on the effects and tolerability of flutamide in a large population of patients with various kinds of hirsutism over a 15-year period
Paradisi, R., & Venturoli, S. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0100 · Cited by 30
Progestin inhibition of estrogen-dependent proliferation in ZR-75-1 human breast cancer cells: Antagonism by insulin
Poulin, R., Dufour, J.-M., & Labrie, F. (1989) · Breast Cancer Research and Treatment · doi:10.1007/bf02106576 · Cited by 30
Self-citation
Interactions between Estrogens, Androgens, Progestins, and Glucocorticoids in ZR‐75‐1 Human Breast Cancer Cells
Labrie, F., Poulin, R., Simard, J., Zhao, H. F., Labrie, C., Dauvois, S., Dumont, M., Hatton, A.-C., Poirier, D., & Mérand, Y. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb34288.x · Cited by 30
Self-citation
Synthetic progestins stimulate prostatic binding protein messenger RNAs in the rat ventral prostate
Labrie, C., Simard, J., Zhao, H., Pelletier, G., & Labrie, F. (1990) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(90)90190-j · Cited by 30
Self-citation
On the Use and Interpretation of Areola/Nipple Retention as a Biomarker for Anti-androgenic Effects in Rat Toxicity Studies
Schwartz, C. L., Christiansen, S., Hass, U., Ramhøj, L., Axelstad, M., Löbl, N. M., & Svingen, T. (2021) · Frontiers in Toxicology · doi:10.3389/ftox.2021.730752 · Cited by 29
Differential Expression of 3.BETA.-Hydroxysteroid Dehydrogenase mRNA in Rat Testes Exposed to Endocrine Disruptors
Kim, H., Kwak, D. H., Yon, J., Baek, I., Lee, S.-R., Lee, J.-E., Nahm, S., Jeong, J., Lee, B. J., Yun, Y. W., et al. (2007) · Journal of Reproduction and Development · doi:10.1262/jrd.18134 · Cited by 29
Sequential Androgen Blockade: A Biological Study in the Inhibition of Prostatic Growth
Fleshner, N. E., & Trachtenberg, J. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)37086-6 · Cited by 29
LHRH Agonists and Antiandrogens in Prostate Cancer
Labrie, F., Dupont, A., & Bélanger, A. (1987) · Cancer treatment and research · doi:10.1007/978-1-4613-2033-3_15 · Cited by 29
Self-citation
Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of type 3 17β-hydroxysteroid dehydrogenase
Maltais, R., Luu-The, V., & Poirier, D. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00182-1 · Cited by 28
Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats
Ward, G. R., & Abdel‐Rahman, A. A. (2006) · BMC Pharmacology · doi:10.1186/1471-2210-6-2 · Cited by 27
Castration levels of plasma testosterone have potent stimulatory effects on androgen-sensitive parameters in the rat prostate
Marchetti, B., Poulin, R., Plante, M., & Labrie, F. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90309-3 · Cited by 27
Self-citation
Prenatal exposure to the phthalate DEHP impacts reproduction-related gene expression in the pituitary
Ge, X., Weis, K. E., Flaws, J. A., & Raetzman, L. T. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.12.008 · Cited by 26
Androgen deprivation therapy for patients with clinically localized (stages T1 to T3) prostate cancer and for patients with biochemical recurrence after radical prostatectomy
Grossfeld, G. D., Small, E. J., Lubeck, D. P., Latini, D. M., Broering, J. M., & Carroll, P. R. (2001) · Urology · doi:10.1016/s0090-4295(01)01243-2 · Cited by 26
Anti-androgens for the treatment of hirsutism
Carmina, E. (2002) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.11.3.357 · Cited by 26
A Molecular and Phenotypic Integrative Approach to Identify a No-Effect Dose Level for Antiandrogen-Induced Testicular Toxicity
Ludwig, S., Tinwell, H., Schorsch, F., Cavaillé, C., Pallardy, M. J., Rouquié, D., & Bars, R. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr099 · Cited by 25
Differential effects of yolk hormones on maternal and paternal contribution to parental care
Tschirren, B., & Richner, H. (2008) · Animal Behaviour · doi:10.1016/j.anbehav.2008.01.007 · Cited by 25
Plasma levels of hydroxy‐flutamide in patients with prostatic cancer receiving the combined hormonal therapy: An LHRH agonist and flutamide
Bélanger, A., Giasson, M., Couture, J., Dupont, A., Cusan, L., & Labrie, F. (1988) · The Prostate · doi:10.1002/pros.2990120110 · Cited by 25
Self-citation
Combination therapy with flutamide and castration (LHRH agonist or orchiectomy) in previously untreated patients with clinical stage D2 prostate cancer: Today's therapy of choice
Labrie, F., Dupont, A., Cusan, L., Giguère, M., Beroeron, N., Borsanyi, J.-P., Lacourcière, Y., Bélanger, A., Emond, J., Monfette, G., et al. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90083-0 · Cited by 25
Self-citation
Molecular dynamics simulation of drug delivery across the cell membrane by applying gold nanoparticle carrier: Flutamide as hydrophobic and glutathione as hydrophilic drugs as the case studies
Farhadian, N., Kazemi, M. S., Moosavi, F., & Khalaj, M. (2022) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2022.108271 · Cited by 24
Polycystic ovary Syndrome in Adolescents: Pitfalls in Diagnosis and Management
Kostopoulou, E., Anagnostis, P. G., Bosdou, J. Κ., Spiliotis, B. E., & Goulis, D. G. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00388-9 · Cited by 24
How the study of the biological activities of antiandrogens can be oriented towards the clinic
Moguilewsky, M., & Bouton, M. M. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90021-0 · Cited by 23
Development of an immuno-immobilized androgen receptor assay (IRA) and its application for the characterization of the receptor binding affinity of different pesticides
BAUER, E. R. S., Bitsch, N., Brunn, H. E., Sauerwein, H., & MEYER, H. H. D. (2002) · Chemosphere · doi:10.1016/s0045-6535(01)00145-x · Cited by 23
Correlation between Protein Accumulation Profiles and Conventional Toxicological Findings Using a Model Antiandrogenic Compound, Flutamide
Friry-Santini, C., Rouquié, D., Kennel, P., Tinwell, H., Benahmed, M., & Bars, R. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm022 · Cited by 23
Hepatotoxicity during low-dose flutamide treatment for hirsutism
Castelo‐Branco, C., & Pino, M. L. D. (2009) · Gynecological Endocrinology · doi:10.1080/09513590902730754 · Cited by 23
EFFECTS OF FLUTAMIDE ON PUBERTY IN MALE RATS: AN EVALUATION OF THE PROTOCOL FOR THE ASSESSMENT OF PUBERTAL DEVELOPMENT AND THYROID FUNCTION
Shin, J., Kim, H. S., Moon, H. J., Kang, I. H., Kim, T. S., Seok, J. H., Kim, I. Y., Park, K. L., Han, S. Y., & Nam, S.-Y. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390252808091 · Cited by 23
Effects of the aromatase inhibitor 4-hydroxyandrostenedione and the antiandrogen flutamide on growth and steroid levels in DMBA-induced rat mammary tumors
Spinola, P. G., Marchetti, B., Mérand, Y., Bélanger, A., & Labrie, F. (1988) · Breast Cancer Research and Treatment · doi:10.1007/bf01811241 · Cited by 22
Self-citation
Adrenal C19-5-ene steroids induce full estrogenic responses in rat pituitary gonadotrophs
Simard, J., & Labrie, F. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90005-7 · Cited by 22
Self-citation
Silver‐Promoted Fluorination Reactions of α‐Bromoamides
Mizuta, S., Kitamura, K., Kitagawa, A., Yamaguchi, T., & Ishikawa, T. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004769 · Cited by 22
(+)-(2R,5S)-4-[4-Cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an Orally Potent and Peripherally Selective Nonsteroidal Androgen Receptor Antagonist
Kinoyama, I., Taniguchi, N., Toyoshima, A., Nozawa, E., Kamikubo, T., Imamura, M., Matsuhisa, A., Samizu, K., Kawanimani, E., Niimi, T., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050293c · Cited by 22
Antiandrogen Flutamide Protects Male Mice From Androgen-Dependent Toxicity in Three Models of Spinal Bulbar Muscular Atrophy
Renier, K. J., Troxell‐Smith, S. M., Johansen, J. A., Katsuno, M., Adachi, H., Sobue, G., Chua, J. P., Kim, H. S., Lieberman, A. P., Breedlove, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1756 · Cited by 21
Using Molecular Initiating Events To Generate 2D Structure–Activity Relationships for Toxicity Screening
Allen, T. E. H., Liggi, S., Goodman, J. M., Gutsell, S., & Russell, P. J. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00101 · Cited by 20
A comparison between finasteride, flutamide, and finasteride plus flutamide combination in the treatment of hirsutism
Unluhizarci, K., Özel, D., Tanrıverdi, F., Karaca, Z., & Keleştimur, F. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345676 · Cited by 21
Ex Vivoandin VitroTestis and Ovary Explants: Utility for Identifying Steroid Biosynthesis Inhibitors and Comparison to a Tier I Screening Battery,
Powlin, S. S. (1998) · Toxicological Sciences · doi:10.1006/toxs.1998.2560 · Cited by 21
Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients
Labrie, F., Dupont, A., Giguère, M., Borsanyi, J.-P., Lacourcière, Y., Bèlanger, A., Lachance, R., Emond, J., & Monfette, G. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90350-5 · Cited by 21
Self-citation
Pharmacological profile of RU 58642, a potent systemic antiandrogen for the treatment of androgen-dependent disorders
Battmann, T., Branche, C., Bouchoux, F., Cerede, E., Philibert, D., Goubet, F., Teutsch, G., & Gaillard-Kelly, M. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00151-9 · Cited by 20
Androgens and Therapeutic Aspects of Antiandrogens in Women
Diamanti‐Kandarakis, E., Tolis, G., & Dulęba, A. J. (1995) · Journal of the Society for Gynecologic Investigation · doi:10.1016/1071-5576(95)00002-v · Cited by 19
Synthesis and clinical application of small-molecule drugs approved to treat prostatic cancer
Zhang, J., Zhao, L.-J., & Wang, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115925 · Cited by 19
THE EFFECT OF ANDROGEN BLOCKADE ON PULSATILE GONADOTROPHIN RELEASE AND LH RESPONSE TO NALOXONE
Balzano, S., Migliari, R., Sica, V., Scarpa, R. M., PINTUS, C., Loviselli, A., Usai, E., & BALESTRIERI, A. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb01178.x · Cited by 19
Lack of anti-androgenic effects of equol on reproductive neuroendocrine function in the adult male rat
Loutchanwoot, P., Srivilai, P., & Jarry, H. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.10.013 · Cited by 18
Growth inhibition of DMBA-induced rat mammary carcinomas by the antiandrogen flutamide
Boccuzzi, G., Tamagno, E., Brignardello, E., Monaco, M. D., Aragno, M., & Danni, O. (1995) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01198096 · Cited by 18
Combination therapy with flutamide and medical (LHRH agonist) or surgical castration in advanced prostate cancer: 7-year clinical experience
Labrie, F., Dupont, A., Cusan, L., Gomez, J., Emond, J., & Monfette, G. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90448-t · Cited by 18
Self-citation
Effect induced by hemisuccinate of pregnenolone on perfusion pressure and vascular resistance in isolated rat heart
Lauro, F., Díaz-Cedillo, F., Diaz-Ku, E., & Camacho‐Luis, A. (2009) · African Journal of Pharmacy and Pharmacology · Cited by 17
Novel androgen-induced activity of an antimicrobial β-defensin: Regulation of Wolffian duct morphogenesis
Ribeiro, C. M., Ferreira, L. G. A., Thimoteo, D. S., Smith, L. B., Hinton, B. T., & Avellar, M. C. W. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.016 · Cited by 17
Effects of prenatal antiandrogen treatment on masculinization and defeminization of guinea pigs
Thornton, J. E., Irving, S., & Goy, R. W. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90532-s · Cited by 17
A Risk-Benefit Assessment of Pharmacological Therapies for Hirsutism
Carmina, E. (2001) · Drug Safety · doi:10.2165/00002018-200124040-00004 · Cited by 17
Comparison of spironolactone and spironolactone plus finasteride in the treatment of hirsutism
Ünlühızarcı, K., Everest, H., Bayram, F., & Keleştimur, F. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04294-2 · Cited by 16
Leptin Levels Increase during Flutamide Therapy in Women with Polycystic Ovary Syndrome
Şahin, İ., Serter, R., Karakurt, F., Demi̇rbaş, B., Güler, S., Çulha, C., Taşkapan, Ç., & Aral, Y. (2003) · Hormone Research in Paediatrics · doi:10.1159/000074037 · Cited by 16
Emerging biological observations in prostate cancer
Shah, S., & Small, E. J. (2009) · Expert Review of Anticancer Therapy · doi:10.1586/era.09.161 · Cited by 15
Synthesis and Pharmacological Evaluation of Novel Arylpiperazine Derivatives as Nonsteroidal Androgen Receptor Antagonists
Kinoyama, I., Taniguchi, N., Yoden, T., Koutoku, H., Furutani, T., Kudoh, M., & Okada, M. (2004) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.52.1330 · Cited by 15
Ornithine decarboxylase activity as a marker of androgen and antiandrogen action in the rat epididymis
Heras, M. A. D. L., Suescun, M. O., & Calandra, R. S. (1988) · Reproduction · doi:10.1530/jrf.0.0830177 · Cited by 15
Opposite effects of estrogen and the progestin R5020 on cell proliferation and GCDFP-15 expression in ZR-75-1 human breast cancer cells
Dauvois, S., Simard, J., Dumont, M., Haagensen, D. E., & Labrie, F. (1990) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(90)90130-z · Cited by 15
Self-citation
Testosterone reduces cumulative burying in female Wistar rats with minimal participation of estradiol
Gutiérrez‐García, A. G., Contreras, C. M., Vásquez-Hernández, D. I., Molina‐Jiménez, T., & Jacome-Jacome, E. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.06.002 · Cited by 15
Glucocorticoids stimulate the growth of mouse mammary carcinoma Shionogi cells in culture
Labrie, F., Veilleux, R., & Fournier, A. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90156-6 · Cited by 14
Self-citation
Nuclear Androgen Receptor Dynamics in Testicular Peritubular and Sertoli Cells
Buzek, S. W., & Sanborn, B. M. (1990) · Journal of Andrology · doi:10.1002/j.1939-4640.1990.tb00189.x · Cited by 14
Important prognostic value of standardized objective criteria of response in stage D2 prostatic carcinoma
Labrie, F., Dupont, A., Giguère, M., Cusan, L., Bergeron, N., Emond, J., Monfette, G., Lacourcière, Y., Boucher, H., & Lachance, R. (1988) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(88)90100-9 · Cited by 14
Self-citation
Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination
Bahceci, M., Bilge, M., Tuzcu, A., Tuzcu, S., & Bahceci, S. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03351061 · Cited by 13
Evaluation of efficacy of QR 678 and QR678 neo hair growth factor formulation for the treatment of female pattern alopecia in patients with PCOS—A prospective study
Kapoor, R., Shome, D., Doshi, K., Patel, G., & Vadera, S. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13673 · Cited by 13
Expression Pattern of Sulfated Glycoprotein-2 (SGP-2) mRNA in Rat Testes Exposed to Endocrine Disruptors
Yon, J., Kwak, D. H., Young Kwang, C. H. O., Lee, S.-R., Yan, J., Baek, I., Lee, J. E., Nahm, S., Choo, Y., Lee, B. J., et al. (2007) · Journal of Reproduction and Development · doi:10.1262/jrd.19032 · Cited by 13
Regression of the Mammary Branch of the Genitofemoral Nerve May be Necessary for Testicular Descent in Rats
Su, S., Farmer, P. J., Li, R., Sourial, M., Buraundi, S., Bodemer, D., Southwell, B. R., & Hutson, J. M. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.02.041 · Cited by 13
Consequences of Mutations in Androgen Receptor Genes
McGinnis, M. Y., Marcelli, M., & Lamb, D. J. (2002) · Hormones, Brain and Behavior · doi:10.1016/b978-012532104-4/50095-0 · Cited by 13
Morphologic and biochemical changes in male rat lung after surgical and pharmacological castration
Ojeda, M. S., Gómez, N. N., Gil, E., Scardapane, L., & Giménez, M. S. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000000300004 · Cited by 13
Sex differences in the analgesic effects of ICI 182,780 and Flutamide on ureteral calculosis in rats
Affaitati, G., Ceccarelli, I., Fiorenzani, P., Rossi, C., Pace, M. C., Passavanti, M. B., Aurilio, C., Sorda, G., Danielli, B., Giamberardino, M. A., et al. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.008 · Cited by 12
Effects of Two Non‐Steroidal Antiandrogens on Testicular Function in Prepubertal Rats
Rulli, S. B., González-Calvar, S. I., Campo, S., & Calandra, R. S. (1995) · Journal of Andrology · doi:10.1002/j.1939-4640.1995.tb00518.x · Cited by 12
Testosterone Suppression of Ornithine Decarboxylase Activity in Rat Sertoli Cells*
Swift, T. A., & Dias, J. A. (1988) · Endocrinology · doi:10.1210/endo-123-2-687 · Cited by 12
Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin
Sourla, A., Richard, V., Labrie, F., & Labrie, C. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1660455 · Cited by 11
Self-citation
Synthesis and application of a 0D/2D nanocomposite for the nanomolar level detection of an antiandrogen drug
Santhosh, A. S., Sahana, K. M., Sandeep, S., Kumar, P. N. P., Alsaiari, N. S., Katubi, K. M., Abualnaja, K. M., & Rajabathar, J. R. (2022) · New Journal of Chemistry · doi:10.1039/d2nj01967a · Cited by 11
Design and synthesis of new dihydrotestosterone derivative with positive inotropic activity
Lauro, F., Díaz-Cedillo, F., Elodia, G.-C., Eduardo, P.-G., Marcela, R., Lenin, H.-H., & Betty, S.-A. (2015) · Steroids · doi:10.1016/j.steroids.2014.12.026 · Cited by 11
In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3
Roy, J., Fournier, M.-A., Maltais, R., Kenmogne, L. C., & Poirier, D. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.12.019 · Cited by 12
Photodegradation of Flutamide and Halogen Derivatives of Nitrobenzotrifluoride: The NO Release Channel
Bejoy, N. B., & Patwari, G. N. (2023) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.3c03024 · Cited by 9
Distinct roles of age and abdominal visceral fat in reducing androgen receptor‐dependent negative feedback on LH secretion in healthy men
Takahashi, P. Y., Liu, P. Y., & Veldhuis, J. D. (2014) · Andrology · doi:10.1111/j.2047-2927.2014.00218.x · Cited by 9
The Effect of Levonorgestrel on Fibrinolytic Factors in Human Endometrial Endothelial Cells
Pakrashi, T., Taylor, J. E., Nelson, A., Archer, D. F., & Jacot, T. A. (2016) · Reproductive Sciences · doi:10.1177/1933719116645193 · Cited by 9
Synthesis and application of clinically approved small-molecule drugs targeting androgen receptor
Gao, H., Zhang, J., Zhao, L.-J., & Guo, Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106998 · Cited by 8
Co‐treatment with the non‐steroidal anti‐androgen drug, flutamide and the natural estrogen, 17β‐estradiol does not lead to additive reproductive impairment in juvenile Murray rainbowfish (Melanotaenia fluviatilis)
Bhatia, H., Kumar, A., Du, J. C., Chapman, J. C., & McLaughlin, M. J. (2015) · Journal of Applied Toxicology · doi:10.1002/jat.3135 · Cited by 8
Human Relevance of Rodent Leydig Cell Tumors
Steinbach, T., Maronpot, R. R., & Hardisty, J. F. (2015) · John Wiley & Sons, Inc. eBooks · doi:10.1002/9781118834015.ch109 · Cited by 8
Positive inotropic activity induced by a dehydroisoandrosterone derivative in isolated rat heart model
Lauro, F., Díaz-Cedillo, F., García-Cervera, E., Gómez, E. P., López-Ramos, M., Marcela, R., & Martínez-Camacho, R. O. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0166-7 · Cited by 8
The rise in testicular androgens during the first days of treatment with an LHRH agonist in the dog can be blocked by aminoglutethimide or ketoconazole
Lacoste, D., St‐Arnaud, R., Caron, S., Bèlanger, A., & Labrie, F. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90339-1 · Cited by 8
Self-citation
Effects of Flutamide, a pure antiandrogen, on endocrine parameters, in the adult female rat
Lüthy, I. A., Caron, S., Bèlanger, A., & Labrie, F. (1987) · Gynecological Endocrinology · doi:10.3109/09513598709030679 · Cited by 8
Self-citation
A pure antiandrogen does not interfere with the LHRH agonist-induced blockade of testicular androgen secretion in the dog
Lacoste, D., St‐Arnaud, R., Bèlanger, A., & Labrie, F. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90018-4 · Cited by 8
Self-citation
Potent Antagonism between Estrogens and Androgens on GCDFP‐15 Expression and Cell Growth in the ZR‐75‐1 Human Breast Cancer Cellsa
Labrie, F., Simard, J., Poulin, R., Hatton, A.-C., Labrie, C., Dauvois, S., Zhao, H., PETITCLERC, L., Couët, J., Dumont, M., et al. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17805.x · Cited by 7
Self-citation
Methodology for developing data-rich Key Event Relationships for Adverse Outcome Pathways exemplified by linking decreased androgen receptor activity with decreased anogenital distance
Holmer, M. L., Zilliacus, J., Draskau, M. K., Hlisníková, H., Beronius, A., & Svingen, T. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108662 · Cited by 6
Antiandrogen effects in models of androgen responsive cancer
Shain, S. A., & Huot, R. I. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90022-2 · Cited by 6
Efficacy and Safety of Topical Flutamide 1% Gel as an Adjunctive Therapy in the Treatment of Patients With Acne Vulgaris
Nassar, A., Sayed, A. E., Samy, A., & Essam, R. (2023) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/12034754231191475 · Cited by 5
The challenging role of antiandrogens in the management of polycystic ovary syndrome
Papadimitriou, K., Anagnostis, P. G., & Goulis, D. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823045-9.00013-4 · Cited by 5
Effect of two Antiandrogens as Protectors of Prostate and Brain in a Huntington´s Animal Model
Guzmán, D. C., Bratoeff, E., Chávez‐Riveros, A., Brizuela, N. O., Mejía, G. B., García, E. H., Olguín, H. C., & Cruz, E. G. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520614666141010094847 · Cited by 5
Evaluation and Treatment of Hirsutism
Dash, K. (2013) · Apollo Medicine · doi:10.1016/j.apme.2013.05.021 · Cited by 5
Effect of antiandrogen flutamide on measures of hepatic regeneration in rats
Svanas, G. W., Eagon, P. K., Elm, M. S., Makowka, L., Podestá, L. G., Chapchap, P., Kahn, D. R., Starzl, T. E., & Thiel, D. H. V. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01536712 · Cited by 5
Ovarian Suppression and Treatment of Hirsutism
Moghetti, P. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-179-6_34 · Cited by 5
Combination therapy in stage C and D prostatic cancer: rationale and five-year clinical experience
Labrie, F., Dupont, A., B�langer, A., Cusan, L., Gigu�re, M., re, Y. L., Lüthy, I. A., B�gin, D., Labrie, C., Simard, J., et al. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00047470 · Cited by 5
Self-citation
Clinical management of androgen excess and defect in women
Rosato, E., Sciarra, F., Minnetti, M., Degjoni, A., & Venneri, M. A. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2279537 · Cited by 4

Authors: Simard, J., Luthy, I., Guay, J., Bélanger, A., & Labrie, F.
Affiliations: Université Laval (CA)
ORCID: Simard, J.
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 1986-03
Volume: 44
Issue: 3
Pages: 261-270
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/0303-7207(86)90132-2
OpenAlex: W2036335596
Cited by: 256
References: 33
Citations by year: 2026: 3 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 7 · 2012: 5
FWCI: 26.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Fonds de Recherche du Québec - Santé
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: flutamide, androgen receptor antagonists, androgen receptor, receptor binding affinity, testosterone uptake, anterior pituitary, ventral prostate, uterus, breast cancer, dihydrotestosterone
MeSH terms: Anilides, Animals, Cells, Cultured, Female, Flutamide, Humans, Kinetics, Male, Mammary Neoplasms, Experimental, Mice, Inbred Strains, Organ Specificity, Pituitary Gland, Anterior, Prostate, Prostatic Neoplasms, Rats, Inbred Strains, Receptors, Androgen, Testosterone, Uterus, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks