Simard, Jacques

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Kuchenbaecker, K. B., Hopper, J. L., Barnes, D. R., Phillips, K.-A., Mooij, T. M., Roos-Blom, M.-J., Jervis, S., van Leeuwen, F. E., Milne, R. L., Andrieu, N., et al. (2017) · JAMA

BRCA gene mutations in cancerMultiple and Secondary Primary Cancers

Cited by 2,954

Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family

Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 620

Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone

Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews

Estrogen and related hormone effectsHormonal and reproductive studies

Cited by 544

Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer

Rebbeck, T. R., Mitra, N., Wan, F., Sinilnikova, O. M., Healey, S., McGuffog, L., Mazoyer, S., Chenevix-Trench, G., Easton, D. F., Antoniou, A. C., et al. (2015) · JAMA

BRCA gene mutations in cancerMultiple and Secondary Primary Cancers

Cited by 521

The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

Labrie, F., Luu-The, V., Lin, S.-X., Claude, L., Simard, J., Breton, R., & Bélanger, A. (1997) · Steroids

Estrogen and related hormone effectsSteroid Chemistry and Biochemistry

Cited by 480

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

The PRACTICAL Consortium, Day, F. R., kConFab Investigators, AOCS Investigators, Scotland, G., EPIC-InterAct Consortium, Study, L. C., Ruth, K. S., Thompson, D. J., Lunetta, K. L., et al. (2015) · Nature Genetics

Genetic Associations and EpidemiologyBRCA gene mutations in cancer

Cited by 402

DHEA and its transformation into androgens and estrogens in peripheral target tissues: Intracrinology

Labrie, F., Luu-The, V., Labrie, C., & Simard, J. (2001) · Frontiers in Neuroendocrinology

Estrogen and related hormone effectsAdrenal Hormones and Disorders

Cited by 366

Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ 5 -Δ 4 -lsomerase in Human Adrenals and Gonads

Rhéaume, E., Lachance, Y., Zhao, H.-F., Breton, N., Dumont, M., Launoit, Y. D., Trudel, C., Luu-The, V., Simard, J., & Labrie, F. (1991) · Molecular Endocrinology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 362

DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: its role during aging

Labrie, F., Bélanger, A., Luu-The, V., Labrie, C., Simard, J., Cusan, L., Gomez, J.-L., & Candas, B. (1998) · Steroids

Hormonal and reproductive studiesAdrenal Hormones and Disorders

Cited by 347

17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

Peltoketo, H., Luu-The, V, Simard, J., & Adamski, J. (1999) · Journal of Molecular Endocrinology

Steroid Chemistry and BiochemistrySexual Differentiation and Disorders

Cited by 302

DHEA and peripheral androgen and estrogen formation: intracrinology

LABRIE, F., BÉLANGER, A., SIMARD, J., LUU‐THE, V., & LABRIE, C. (1995) · Annals of the New York Academy of Sciences

Adrenal Hormones and DisordersHormonal and reproductive studies

Cited by 280

Intracrinology: Role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease

Labrie, F., Luu-The, V, Lin, S., Simard, J., Labrie, C., El-Alfy, M., Pelletier, G., & Belanger, A. (2000) · Journal of Molecular Endocrinology

Estrogen and related hormone effectsSteroid Chemistry and Biochemistry

Cited by 278

Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues.

Simard, J., Luthy, I., Guay, J., Bélanger, A., & Labrie, F. (1986) · Molecular and Cellular Endocrinology

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 256

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

EMBRACE, Kuchenbaecker, K. B., Collaborators, G. S., Breast Cancer Family Registry, HEBON, KConFab Investigators, Australian Cancer Study (Ovarian Cancer Investigators), Australian Ovarian Cancer Study Group, the Consortium of Investigators of Modifiers of BRCA1 and BRCA2, Ramus, S. J., et al. (2015) · Nature Genetics

BRCA gene mutations in cancerOvarian cancer diagnosis and treatment

Cited by 250

Congenital adrenal hyperplasia due to point mutations in the type II 3β-hydroxysteroid dehydrogenase gene

Rhéaume, E., Simard, J., Morel, Y., Mebarki, F., Zachmann, M., Forest, M. G., New, M. I., & Labrie, F. (1992) · Nature Genetics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 235

Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues.

Martel, C., Rhéaume, E., Takahashi, M., Trudel, C., Couët, J., Luu-The, V., Simard, J., & Labrie, F. (1992) · The Journal of Steroid Biochemistry and Molecular Biology

Estrogen and related hormone effectsSteroid Chemistry and Biochemistry

Cited by 231

Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

Lachance, Y., Luu-The, V, Labrie, C., Simard, J., Dumont, M., de Launoit, Y., Guérin, S., Leblanc, G., & Labrie, F. (1990) · Journal of Biological Chemistry

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 201

Structure of two in tandem human 17β-hydroxysteroid dehydrogenase genes

Luu-The, V., Labrie, C., Simard, J., Lachance, Y., Zhao, H.-F., Couët, J., Leblanc, G., & Labrie, F. (1990) · Molecular Endocrinology

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 173

Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

Phillips, K.-A., Milne, R. L., Rookus, M. A., Daly, M. B., Antoniou, A. C., Peock, S., Frost, D., Easton, D. F., Ellis, S., Friedlander, M. L., et al. (2013) · Journal of Clinical Oncology

BRCA gene mutations in cancerMultiple and Secondary Primary Cancers

Cited by 171

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

EMBRACE, Dunning, A. M., Collaborators, G. S., HEBON, kConFab Investigators, Michailidou, K., Kuchenbaecker, K. B., Thompson, D., French, J. D., Beesley, J., et al. (2016) · Nature Genetics

Genetic Associations and EpidemiologyEstrogen and related hormone effects

Cited by 161

Structure, function and tissue-specific gene expression of 3β-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase enzymes in classical and peripheral intracrine steroidogenic tissues.

Labrie, F., Simard, J., Luu-The, V., Bélanger, A., & Pelletier, G. (1992) · The Journal of Steroid Biochemistry and Molecular Biology

Adrenal Hormones and DisordersEstrogen and related hormone effects

Cited by 132

Down-regulation of estrogen receptors by androgens in the ZR-75-1 human breast cancer cell line.

POULIN, R., SIMARD, J., LABRIE, C., PETITCLERC, L., DUMONT, M., LAGACÉ, L., & LABRIE, F. (1989) · Endocrinology

Estrogen and related hormone effectsBreast Cancer Treatment Studies

Cited by 115

Regulation of progesterone-binding breast cyst protein GCDFP-24 secretion by estrogens and androgens in human breast cancer cells: a new marker of steroid action in breast cancer.

SIMARD, J., DAUVOIS, S., HAAGENSEN, D. E., LÉVESQUE, C., MÉRAND, Y., & LABRIE, F. (1990) · Endocrinology

Estrogen and related hormone effectsBreast Cancer Treatment Studies

Cited by 107

New Insight into the Molecular Basis of 3β-Hydroxysteroid Dehydrogenase Deficiency: Identification of Eight Mutations in the HSD3B2 Gene in Eleven Patients from Seven New Families and Comparison of the Functional Properties of Twenty-Five Mutant Enzymes1

Moisan, A. M., Ricketts, M. L., Tardy, V., Desrochers, M., Mébarki, F., Chaussain, J.-L., Cabrol, S., Raux-Demay, M. C., Forest, M. G., Sippell, W. G., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 107