Activation of lymphocytes of normal and tumor bearing mice by mangiferin, a naturally occurring glucosylxanthone
Abstract
Mangiferin, a naturally occurring glucosylxanthone, was assessed for its immunomodulatory potential. The phytochemical induced extensive in vitro proliferation of murine splenocytes and thymocytes at the doses of 5-40 micrograms ml-1. Suppression of the proliferative response of the cells was observed with higher doses of mangiferin. Mangiferin also activated the splenocytes of tumor hosts at early and late stages of tumor growth. The Phytohemagglutinin (PHA) and Con A unresponsive splenocytes of advanced tumor bearer proliferated extensively in response to mangiferin. Mangiferin when used with Con A produced additive stimulatory effect and induced heightened DNA synthesis of normal and advanced tumor bearers' splenocytes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Surface Modulation in Cell Recognition and Cell Growth
Edelman, G. M. (1976) · Science · doi:10.1126/science.769162 · Cited by 1,057 · see citing works
KIERSZENBAUM, F. (1977) · PubMed Central · Cited by 216 · see citing works
Splenic Suppressor Macrophages Induced in Mice by Injection of Corynebacterium Parvum
Kirchner, H., Holden, H. T., & Herberman, R. B. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.115.5.1212 · Cited by 131 · see citing works
ZINC REQUIREMENT FOR DNA REPLICATION IN STIMULATED HUMAN LYMPHOCYTES
Williams, R. O., & Loeb, L. A. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.58.3.594 · Cited by 119 · see citing works
Chemical Constituents of the Gentianaceae V: Tetraoxygenated Xanthones of Swertia chirata Buch.-Ham.
Ghosal, S., Sharma, P. V., Chaudhuri, R. K., & Bhattacharya, S. K. (1973) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600620614 · Cited by 75 · see citing works
Self-citationXanthones of Canscora decussata schult
Chaudhuri, R. K., & Ghosal, S. (1971) · Phytochemistry · doi:10.1016/s0031-9422(00)89890-8 · Cited by 63 · see citing works
Self-citationStimulation of murine lymphocyte responses by cations
Warner, G. L., & Lawrence, D. A. (1986) · Cellular Immunology · doi:10.1016/0008-8749(86)90155-3 · Cited by 61 · see citing works
Clinical Immunologic Responsiveness in Malignant Disease
Al‐Sarraf, M., Sardesai, S., & Vaitkevicius, V. K. (2009) · Oncology · doi:10.1159/000224687 · Cited by 46 · see citing works
Brock, J., Mainou‐Fowler, T., & Webster, L. M. (1986) · PubMed · Cited by 36 · see citing works
Ghosal, S., Biswas, K., & Chattopadhyay, B. K. (1978) · Phytochemistry · doi:10.1016/s0031-9422(00)94210-9 · Cited by 30 · see citing works
Self-citationMalavé, I., & Benaím, I. R. (1984) · Cellular Immunology · doi:10.1016/0008-8749(84)90334-4 · Cited by 20 · see citing works
Toxic substances produced byFusarium. X. Concerning the malformation disease of mango
Ghosal, S., Chakrabarti, D. K., Biswas, K., et al. (1979) · Cellular and Molecular Life Sciences · doi:10.1007/bf01953237 · Cited by 17 · see citing works
Self-citationKilburn, D. G., Fairhurst, M., Levy, J. G., et al. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.117.5_part_1.1612 · Cited by 14 · see citing works
Activation of lymphocytes by lycorine-1-O-beta-D-glucoside.
Chattopadhyay, U., Chaudhuri, L., Das, S., et al. (1984) · PubMed · Cited by 8 · see citing works
Self-citationEffect of mangiferin, a naturally occurring glucosylxanthone, on reproductive function of rats.
Chattopadhyay, S., Chattopadhyay, U., Shukla, S. P., et al. (1984) · Pharmaceutical Research · doi:10.1023/a:1016306304849 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Das, 1986, Lymphocyte response to phytohemagglutinin in patients with carcinoma of the cervix, before and after therapy, IRCS Med. Sci., 14, 841
Cited by
Sorted by citations
<i>Mangifera indica</i> L. extract (Vimang) and mangiferin modulate mouse humoral immune responses
García, D., Leiro, J., Delgado, R., Sanmartín, M. L., & Ubeira, F. M. (2003) · Phytotherapy Research · doi:10.1002/ptr.1338 · Cited by 116 · see citing works
Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
- Authors
- Chattopadhyay, U., Das, S., Guha, S., & Ghosal, S.
- Affiliations
- Chittaranjan National Cancer Institute (IN)
- Banaras Hindu University (IN)
- Corresponding author
- Chattopadhyay, Utpala
- ORCID
- Das, Swati
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 37
- Issue
- 3
- Pages
- 293-299
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W1987703797
- Semantic Scholar
- bf28f07a2df36a208684c3ef32a0557bb9e9f9a9
- Cited by
- 35
- References
- 15
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- mangiferin, immunomodulation, lymphocyte activation, splenocytes, thymocytes, tumor-bearing mice, phytohemagglutinin, concanavalin A, DNA synthesis
- MeSH terms
- Adjuvants, Immunologic, Animals, Concanavalin A, Dose-Response Relationship, Drug, Lymphocyte Activation, Neoplasms, Experimental, Phytohemagglutinins, Spleen, Thymus Gland, Xanthenes, Xanthones, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
