Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses
Abstract
The present study investigated the effects of orally administered Vimang (an aqueous extract of Mangifera indica) and mangiferin (the major polyphenol present in Vimang) on mouse antibody responses induced by inoculation with spores of microsporidian parasites. Inoculation induced specific antibody production with an exponential timecourse, peaking after about one month. Vimang significantly inhibited this antibody production from about three weeks post‐inoculation, and most markedly by four weeks post‐inoculation; by contrast, mangiferin had no significant effect. Determination of Ig isotypes showed that the IgM to IgG switch began about four weeks post‐inoculation, with IgG2a predominating. Vimang significantly inhibited IgG production, but had no effect on IgM. Mangiferin did no affect either IgM or IgG2a, but significantly enhanced production of IgG1 and IgG2b. Neither Vimang nor mangiferin enhanced specific antibody secretion by splenic plasma cells from mice inoculated with microsporidian spores, whether administered in vivo before serum extraction or in vitro to the culture medium. Inoculation with spores induced splenomegaly, which was significantly reduced by Vimang and significantly enhanced by mangiferin. These results suggest that components of Mangifera indica extracts may be of potential value for modulating the humoral response in different immunopathological disorders. Copyright © 2003 John Wiley & Sons, Ltd.
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“The major polyphenol component of Vimang is mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside), which has attracted considerable interest in view of its numerous pharmacological activities, including antitumor and antiviral (Zheng and Lu, 1990; Guha et al., 1996; Yoosook et al., 2000; Yos…”
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- Authors
- García, D., Leiro, J., Delgado, R., Sanmartín, M. L., & Ubeira, F. M.
- Affiliations
- Universidade de Santiago de Compostela (ES)
- Corresponding author
- Leiro, J.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2003-12
- Volume
- 17
- Issue
- 10
- Pages
- 1182-1187
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2078964661
- Semantic Scholar
- e75da2608695187d512756047b18381326ffd226
- Cited by
- 116
- References
- 53
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 15 · 2013: 7 · 2012: 2
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Xunta de Galicia (Spain) (PGIDIT-02RMA2370 1PR)
- Agencia Española de Cooperación Internacional (AECI)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- mango, Vimang, mangiferin, humoral immune response, antibody production, microsporidia, IgG isotypes, IgM to IgG switch, splenomegaly, immunomodulation, polyphenols
- MeSH terms
- Adjuvants, Immunologic, Animals, Antibody Formation, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Intubation, Gastrointestinal, Phytotherapy, Mice, Inbred BALB C, Plant Extracts, Spleen, Spores, Bacterial, Microsporidia, Plant Bark, Mangifera, Xanthones, Mice
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