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Cited by 916Carcinogens and Genotoxicity AssessmentPolyamine Metabolism and ApplicationsOral Health Pathology and Treatment

The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.

Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC

Mirvish, Sidney S.·1995·Cancer Letters
DOI 10.1016/0304-3835(95)03786-v
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Abstract

The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in humans are discussed. The principal subjects covered include nitrite-derived alkylating agents that are not NOC, reasons for the wide tissue specificity of carcinogenesis by NOC, the acute toxicity of nitrosamines in humans, mechanisms of in vivo formation of NOC by chemical and bacterial nitrosation in the stomach and via nitric oxide (NO) formation during inflammation, studies on nitrite esters, use of the nitrosoproline test to follow human gastric nitrosation, correlations of nitrate in food and water with in vivo nitrosation and the inhibition of gastric nitrosation by vitamin C and polyphenols. Evidence that specific cancers are caused by NOC is reviewed for cancer of the stomach, esophagus, nasopharynx, urinary bladder in bilharzia and colon. I review the occurrence of nitrosamines in tobacco products, nitrite-cured meat (which might be linked with childhood leukemia and brain cancer) and other foods, and in drugs and industrial situations. Finally, I discuss clues from mutations in ras and p53 genes in human tumors about whether NOC are etiologic agents and draw some general conclusions.

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Citations

Cites

Items 201–222 of 222

Research works printed but not linked: 9

  1. Davidek, 1976, Nitrosation products from creatine and creatinine in meat, Fleischwirtschaft, 56, 99
  2. Day, 1994, Oesophageal cancer, Cancer Surv., 19/20, 43
  3. Janisch, 1972, Die Transplacentare Induktion Geschwulsten des Nervensystems. Vergleichende Untersuchungen der Wirksamkeit von Methyl- und Athylnitrosoharnstoff, Arch. Geschwulstforsch., 39, 95
  4. Ji, 1985, Synthesis of methylbenzylnitrosamine from benzylamine and NaNO2 by fungi, Chin. J. Oncol., 7, 30
  5. Meinsma, 1964, Voeding en Kanker, Voeding, 25, 357
  6. Mirvish, 1978, Studies on rat esophageal epithelium and related tissues: inhibition of [3H]thymidine incorporation into DNA by carcinogenic N-nitroso compounds, Cancer Res., 36, 458
  7. Mirvish, 1995, Time of dosing with ascorbic acid and nitrate, chewing gum and tobacco, and other factors affecting N-nitrosoproline formation in healthy adults taking proline with a standard meal, Cancer Epidemiol. Biomarkers Prev.
  8. Mirvish, 1994, Isobutyl nitrite (IBN) and sodium nitrite deamination of DNA at pH 3 to 9, Toxicologist, 14, 228
  9. Simenhoff, 1983, Generation of dimethylnitrosamine in water purification systems, J. Am. Med. Assoc., 250, 2020, 10.1001/jama.1983.03340150062028 · DOI

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Metadata

Authors
Mirvish, S. S.
Corresponding author
Mirvish, Sidney S.
Venue
Cancer Letters
Publisher
Elsevier BV
Published
1995-06
Volume
93
Issue
1
Pages
17-48
ISSN
0304-3835 (ISSN-L)
DOI
10.1016/0304-3835(95)03786-v
OpenAlex
W2046219406
Cited by
916
References
222
Citations by year
2026: 18 · 2025: 18 · 2024: 18 · 2023: 23 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 29 · 2018: 23 · 2017: 24 · 2016: 36 · 2015: 33 · 2014: 36 · 2013: 33 · 2012: 40
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca035628-11, 5r01ca030593-03)
  • National Cancer Institute (R01-CA-30593, R01 CA-35628, UOI-CA-43236)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords
N-nitroso compounds, nitrosation, nitrosamines, gastric cancer, esophageal cancer, nasopharyngeal carcinoma, bladder cancer, nitrite esters, vitamin C, polyphenols, nitric oxide, inflammation, tobacco, pediatric leukemia, RAS mutations, TP53 mutation, cancer etiology
MeSH terms
Animals, Biotransformation, Urinary Bladder Neoplasms, Carcinogens, Cocarcinogenesis, Environmental Exposure, Esophageal Neoplasms, Food Contamination, Gastrointestinal Neoplasms, Humans, Nasopharyngeal Neoplasms, Nitric Oxide, Nitrosamines, Nitroso Compounds, Genes, ras, Smoking, Stomach Neoplasms, Nitrosation, Genes, p53, Drug-Related Side Effects and Adverse Reactions

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