CoChat
Sign Up
Cited by 916Carcinogens and Genotoxicity AssessmentPolyamine Metabolism and ApplicationsOral Health Pathology and Treatment

The DOI matches its Crossref record; 222 of the 222 references it cites were found in a registry or an index.

Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC

Mirvish, Sidney S.·1995·Cancer Letters
DOI 10.1016/0304-3835(95)03786-v
Open this paper in CoChat — free account

Abstract

The questions of whether and how N-nitroso compounds (NOC) may be inducing cancer in humans are discussed. The principal subjects covered include nitrite-derived alkylating agents that are not NOC, reasons for the wide tissue specificity of carcinogenesis by NOC, the acute toxicity of nitrosamines in humans, mechanisms of in vivo formation of NOC by chemical and bacterial nitrosation in the stomach and via nitric oxide (NO) formation during inflammation, studies on nitrite esters, use of the nitrosoproline test to follow human gastric nitrosation, correlations of nitrate in food and water with in vivo nitrosation and the inhibition of gastric nitrosation by vitamin C and polyphenols. Evidence that specific cancers are caused by NOC is reviewed for cancer of the stomach, esophagus, nasopharynx, urinary bladder in bilharzia and colon. I review the occurrence of nitrosamines in tobacco products, nitrite-cured meat (which might be linked with childhood leukemia and brain cancer) and other foods, and in drugs and industrial situations. Finally, I discuss clues from mutations in ras and p53 genes in human tumors about whether NOC are etiologic agents and draw some general conclusions.

Overview

Integrity signals

Registry

Crossref · 10.1016/0304-3835(95)03786-v

Cites

222 of 222 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 9

  1. Davidek, 1976, Nitrosation products from creatine and creatinine in meat, Fleischwirtschaft, 56, 99
  2. Day, 1994, Oesophageal cancer, Cancer Surv., 19/20, 43
  3. Janisch, 1972, Die Transplacentare Induktion Geschwulsten des Nervensystems. Vergleichende Untersuchungen der Wirksamkeit von Methyl- und Athylnitrosoharnstoff, Arch. Geschwulstforsch., 39, 95
  4. Ji, 1985, Synthesis of methylbenzylnitrosamine from benzylamine and NaNO2 by fungi, Chin. J. Oncol., 7, 30
  5. Meinsma, 1964, Voeding en Kanker, Voeding, 25, 357
  6. Mirvish, 1978, Studies on rat esophageal epithelium and related tissues: inhibition of [3H]thymidine incorporation into DNA by carcinogenic N-nitroso compounds, Cancer Res., 36, 458
  7. Mirvish, 1995, Time of dosing with ascorbic acid and nitrate, chewing gum and tobacco, and other factors affecting N-nitrosoproline formation in healthy adults taking proline with a standard meal, Cancer Epidemiol. Biomarkers Prev.
  8. Mirvish, 1994, Isobutyl nitrite (IBN) and sodium nitrite deamination of DNA at pH 3 to 9, Toxicologist, 14, 228
  9. Simenhoff, 1983, Generation of dimethylnitrosamine in water purification systems, J. Am. Med. Assoc., 250, 2020, 10.1001/jama.1983.03340150062028 · DOI

Cited by

Sorted by citations

See all 916

Related

See all

Metadata

Authors
Mirvish, S. S.
Corresponding author
Mirvish, Sidney S.
Venue
Cancer Letters
Publisher
Elsevier BV
Published
1995-06
Volume
93
Issue
1
Pages
17-48
ISSN
0304-3835 (ISSN-L)
DOI
10.1016/0304-3835(95)03786-v
OpenAlex
W2046219406
Cited by
916
References
222
Citations by year
2026: 18 · 2025: 18 · 2024: 18 · 2023: 23 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 29 · 2018: 23 · 2017: 24 · 2016: 36 · 2015: 33 · 2014: 36 · 2013: 33 · 2012: 40
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ca035628-11, 5r01ca030593-03)
  • National Cancer Institute (R01-CA-30593, R01 CA-35628, UOI-CA-43236)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords
N-nitroso compounds, nitrosation, nitrosamines, gastric cancer, esophageal cancer, nasopharyngeal carcinoma, bladder cancer, nitrite esters, vitamin C, polyphenols, nitric oxide, inflammation, tobacco, pediatric leukemia, RAS mutations, TP53 mutation, cancer etiology
MeSH terms
Animals, Biotransformation, Urinary Bladder Neoplasms, Carcinogens, Cocarcinogenesis, Environmental Exposure, Esophageal Neoplasms, Food Contamination, Gastrointestinal Neoplasms, Humans, Nasopharyngeal Neoplasms, Nitric Oxide, Nitrosamines, Nitroso Compounds, Genes, ras, Smoking, Stomach Neoplasms, Nitrosation, Genes, p53, Drug-Related Side Effects and Adverse Reactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review