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Cited by 433Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

Braak, Heiko, Braak, Eva, Grundke-Iqbal, Inge, Iqbal, Khalid·1986·Neuroscience Letters
DOI 10.1016/0304-3940(86)90288-0
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Abstract

Paired helical filaments, pathologically changed components of the cytoskeleton of human nerve cells, are demonstrated by a specific silver staining technique, immunostaining and electron microscopy. Accumulations of these filaments are found in the telencephalic cortex of old-aged individuals and patients suffering from Alzheimer's disease. Apart from neurofibrillary tangles and neuritic plaques, paired helical filaments are encountered in neuropil threads. At this third location, pathological filaments occur in small and inconspicuous profiles scattered throughout both allocortical and isocortical areas. The pattern of distribution and packing density of neuropil threads varies between different cortical areas and layers.

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Crossref · 10.1016/0304-3940(86)90288-0

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Metadata

Authors
Braak, H., Braak, E., Grundke-Iqbal, I., & Iqbal, K.
Corresponding author
Braak, Heiko
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1986-04
Volume
65
Issue
3
Pages
351-355
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/0304-3940(86)90288-0
OpenAlex
W1984827962
Cited by
432
References
14
Citations by year
2026: 1 · 2025: 9 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
12.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (AG-05892, AG/NS-04220)
  • National Institute of Neurological Disorders and Stroke (NS 18105)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
neuropil threads, paired helical filaments, Alzheimer's disease, neurofibrillary tangles, neuritic plaques, cytoskeletal filaments, silver staining, immunostaining, electron microscopy, cortical layers
MeSH terms
Aged, Aging, Alzheimer Disease, Brain, Cytoskeleton, Humans, Immune Sera, Intermediate Filaments, Microscopy, Electron, Middle Aged, Neurofibrils, Silver, Staining and Labeling

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