Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease
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The tau filaments in Alzheimer's disease have been termed paired helical filaments, exhibit marked periodicity when viewed with electron microscopy, and appear to be composed of two smaller filaments of about 10 nm diameter that twist around one another forming periodic structures with a crossover distance of 65-80 nm.
“The tau filaments in AD have been termed “paired helical filaments” (PHFs) [56], as they exhibit marked periodicity when viewed with electron microscopy, and they appear to be composed of two smaller filaments of about 10 nm diameter that twist around one another forming periodic structures with a crossover distance of 65–80 nm.”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [56]
AD is characterized by intracellular aggregation of microtubule-associated protein tau (MAPT, tau) in neurofibrillary tangles (NFTs).
“and intracellular aggregation of microtubule-associated protein tau (MAPT, tau) in neurofibrillary tangles (NFTs) (7).”
From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [7]
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“The tau filaments in AD have been termed “paired helical filaments” (PHFs) [56], as they exhibit marked periodicity when viewed with electron microscopy, and they appear to be composed of two smaller filaments of about 10 nm diameter that twist around one another forming periodic structures with a crossover distance o…”
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- Authors
- KIDD, M.
- Corresponding author
- KIDD, M.
- Venue
- Nature
- Published
- 1963-01
- Volume
- 197
- Issue
- 4863
- Pages
- 192-193
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1973855353
- Cited by
- 1,012
- References
- 0
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 27 · 2023: 27 · 2022: 33 · 2021: 39 · 2020: 34 · 2019: 27 · 2018: 18 · 2017: 27 · 2016: 27 · 2015: 19 · 2014: 23 · 2013: 18 · 2012: 31
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- paired helical filaments, Alzheimer's disease, neurofibrillary tangles, Congo red staining, birefringence, neurofilaments, cortical neurons, ultrastructure
- MeSH terms
- Alzheimer Disease, Cerebral Cortex, Dementia, Humans, Microscopy, Electron, Neurons, Psychotic Disorders, Neurofibrillary Tangles
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