THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE
Abstract
Robert D. Terry, M.D.; The Fine Structure of Neurofibrillary Tangles in Alzheimer's Disease*†‡, Journal of Neuropathology & Experimental Neurology, Volume
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Previous studies helped establish the connection between amyloid-beta plaques, neurofibrillary tangles, and antemortem cognitive impairment.
“and previous studies that had also helped to establish the connection between AβPs, NFTs, and antemortem cognitive impairment (311-320).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [316]
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“At the electron microscopic level, NFT are composed predominantly of 22-nrn diameter paired helical filaments (PHF) with a variable number of admixed 15- to 18-nm diameter straight filaments (SF), as well as granular material [42, 47].”
BackgroundYoung, I. D., Willmer, J., & Kisilevsky, R. (1989) · Acta Neuropathologica · doi:10.1007/bf00688210 · Cited by 75 · see citing works
“They possess the same tinctorial characteristics as neuritic plaque and cerebrovascular amyloid but ultrastructurally are composed of bundles of 10- to 20-nm paired filaments which are typically helically wound [42, 51 , 61] but which may assume a straight configuration [35].”
BackgroundCharacterization of tau fibrillization in vitro
Xu, S., Brunden, K. R., Trojanowski, J. Q., & Lee, V. M. ‐. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.06.002 · Cited by 73 · see citing works
The Seed Extract of Cassia obtusifolia Offers Neuroprotection to Mouse Hippocampal Cultures
Drever, B. D., Anderson, W. G. L., Riedel, G., Kim, D. H., Ryu, J. H., Choi, D.-Y., & Platt, B. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08034fp · Cited by 72 · see citing works
Spongiform alterations in brain biopsies of presenile dementia
Flament-Durand, J., & Couck, A. M. (1979) · Acta Neuropathologica · doi:10.1007/bf00684819 · Cited by 73 · see citing works
“The fine structure o f the lesions we observed were otherwise typical o f presenile dementia and corresponded to the previous descriptions (Terry, 1963,1976; Wisniewski et al., 1964; Terry and Wisniewski , 1970). Hi rano bodies observed in one o f the specimens are identical to those described by Hi rano et al. (1968)…”
ResultAmyloid precursor protein-induced axonopathies are independent of amyloid-β peptides
Stokin, G. B., Almenar-Queralt, A., Gunawardena, S., Rodrigues, E. M., Falzone, T., Kim, J., Lillo, C., Mount, S. L., Roberts, E. A., McGowan, E., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn240 · Cited by 72 · see citing works
- Authors
- Terry, R. D.
- Corresponding author
- Terry, Robert D.
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1963-10
- Volume
- 22
- Issue
- 4
- Pages
- 629-642
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2070494722
- Cited by
- 403
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 6
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neurofibrillary tangles, Alzheimer's disease, fine structure, ultrastructure, neurofibrillary pathology
- MeSH terms
- Alzheimer Disease, Cerebral Cortex, Dementia, Electrons, Humans, Microscopy, Microscopy, Electron, Neurons, Pathology, Psychotic Disorders, Neurofibrillary Tangles
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