Cellular distribution of ω3 (peripheral type benzodiazepine) binding sites in the normal and ischaemic rat brain: An autoradiographic study with the photoaffinity ligand [3H]PK 14105
Abstract
The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of omega 3 sites were present in the ependymal cells, the apical pole of the secretory cells in the choroid plexus and astrocyte-like cells in the outer cellular layer of the olfactory bulb. In ischaemic brain lesions caused by middle cerebral artery occlusion in spontaneously hypertensive rats or in spontaneous ischaemic and haemorrhagic lesions in spontaneously hypertensive stroke-prone rats, the proliferating omega 3 sites were associated with reactive glial cells and macrophages.
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The choroid plexus was immunoreactive for TSPO in macaque brains.
“In addition, the choroid plexus was also immunoreactive, in agreement with rodent autoradiography studies [33;34].”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [34]
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1 In vitro and in vivo models of cerebral ischaemia
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- Authors
- Benavides, J., Dubois, A., Gotti, B., Bourdiol, F., & Scatton, B.
- Corresponding author
- Scatton, Bernard
- ORCID
- Scatton, Bernard
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1990-06
- Volume
- 114
- Issue
- 1
- Pages
- 32-38
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2002472831
- Cited by
- 39
- References
- 18
- Citations by year
- 2025: 1 · 2021: 1 · 2018: 1
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- cerebral ischemia, ependymal cells, reactive glial cells, macrophages, middle cerebral artery occlusion, stroke-prone spontaneously hypertensive rats, hemorrhagic stroke, receptor autoradiography
- MeSH terms
- Affinity Labels, Animals, Autoradiography, Brain, Brain Ischemia, Isoquinolines, Rats, Inbred SHR, Receptors, GABA-A, Reference Values, Tritium, Rats
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