Cited by 39Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchPharmacological Receptor Mechanisms and Effects

Cellular distribution of ω3 (peripheral type benzodiazepine) binding sites in the normal and ischaemic rat brain: An autoradiographic study with the photoaffinity ligand [3H]PK 14105

Benavides, Jesùs, Dubois, Alain, Gotti, Bernard, Bourdiol, Frédérique, Scatton, Bernard·1990·Neuroscience Letters

Abstract

The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of omega 3 sites were present in the ependymal cells, the apical pole of the secretory cells in the choroid plexus and astrocyte-like cells in the outer cellular layer of the olfactory bulb. In ischaemic brain lesions caused by middle cerebral artery occlusion in spontaneously hypertensive rats or in spontaneous ischaemic and haemorrhagic lesions in spontaneously hypertensive stroke-prone rats, the proliferating omega 3 sites were associated with reactive glial cells and macrophages.

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Crossref · 10.1016/0304-3940(90)90424-8

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Authors
Benavides, J., Dubois, A., Gotti, B., Bourdiol, F., & Scatton, B.
Corresponding author
Scatton, Bernard
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1990-06
Volume
114
Issue
1
Pages
32-38
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2002472831
Cited by
39
References
18
Citations by year
2025: 1 · 2021: 1 · 2018: 1
FWCI
1.68
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Keywords
cerebral ischemia, ependymal cells, reactive glial cells, macrophages, middle cerebral artery occlusion, stroke-prone spontaneously hypertensive rats, hemorrhagic stroke, receptor autoradiography
MeSH terms
Affinity Labels, Animals, Autoradiography, Brain, Brain Ischemia, Isoquinolines, Rats, Inbred SHR, Receptors, GABA-A, Reference Values, Tritium, Rats

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