Cited by 78Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeuroscience and Neuropharmacology Research

Increase inω3 (peripheral type benzodiazepine) binding sites in the rat cortex and striatum after local injection of interleukin-1, tumour necrosis factor-α and lipopolysaccharide

Bourdiol, F., Toulmond, S., Serrano, A., Benavides, J., Scatton, B.·1991·Brain Research

Abstract

The possible involvement of lymphokines in the glial reaction/proliferation that follows brain injury has been investigated by measuring the density of omega 3 (peripheral type benzodiazepine) binding sites associated to glial cells and macrophages after local injection of lymphokines in the rat cerebral cortex and striatum. omega 3 Site densities were measured either by quantitative autoradiography in brain sections or by conventional binding in membrane using [3H]PK 14105 or [3H]PK 11195 as ligands. Intracortical or intrastriatal infusion of interleukin-1 (10 and 20 units) caused a marked increase in the density of omega 3 sites (+83% and +80%, respectively, when compared to saline-infused animals) around the injection site at 7 days postinjection. There was a good spatial correspondence between the autoradiographic distribution of omega 3 sites and the distribution of reactive astrocytes (as assessed by GFAP immunostaining) or acid phosphatase rich cells (phagocytes). Significant increases in omega 3 site densities were also observed in striatal homogenates 1 week after local administration of tumor necrosis factor-alpha (TNF-alpha). The maximal increase (+80%) was observed after the administration of 3 units, higher and lower doses resulting in smaller increases. Intrastriatal injection of E. coli lipopolysaccharide (LPS), a bacterial endotoxin known to stimulate interleukin-1 and TNF-alpha production by microglial cells in culture, also resulted in significant increases…

Integrity signals

Registry

Crossref · 10.1016/0006-8993(91)90028-t

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 34 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Bourdiol, F., Toulmond, S., Serrano, A., Benavides, J., & Scatton, B.
Venue
Brain Research
Publisher
Elsevier BV
Published
1991-03
Volume
543
Issue
2
Pages
194-200
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1980637734
Cited by
77
References
34
Citations by year
2026: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
FWCI
4.52
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
translocator protein (TSPO), interleukin-1, TNF-α, lipopolysaccharide, glial activation, astrocytes, microglia, macrophages, cerebral cortex, striatum, brain injury, lymphokines, NMDA receptor, central benzodiazepine receptor, neuroinflammation
MeSH terms
Animals, Autoradiography, Cerebral Cortex, Corpus Striatum, Flumazenil, Humans, Interleukin-1, Lipopolysaccharides, Male, Membranes, N-Formylmethionine Leucyl-Phenylalanine, Rats, Inbred Strains, Receptors, GABA-A, Stereotaxic Techniques, Tumor Necrosis Factor-alpha, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review