The ventral pallidum area is involved in the acquisition but not expression of the amphetamine conditioned place preference
Abstract
The present study examined the roles of the ventral pallidum area, one output system of the nucleus accumbens, in the acquisition and expression of the amphetamine conditioned place preference (CPP). Pre-conditioning NMDA lesions of the ventral pallidum area completely abolished the acquisition of the CPP. By contrast, post-conditioning NMDA lesions of the same area had no effect on the expression of the CPP. These results suggest that the ventral pallidum area mediates some process that involves the primary, but not conditioned rewarding effects of amphetamine.
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The rewarding or reinforcing value of many drugs of abuse can be blocked by MOR antagonists injected into the nucleus accumbens, ventral pallidum, or VTA.
“Similarly, the rewarding or reinforcing value of many drugs of abuse can be blocked by MOR antagonists injected into the NAC, the VP, or the VTA (Hiroi and White 1993; Skoubis and Maidment 2003; Soderman and Unterwald 2008).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Hiroi and White 1993
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- Authors
- Hiroi, N., & White, N. M.
- Affiliations
- McGill University (CA)
- Corresponding author
- Hiroi, Noboru
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 156
- Issue
- 1-2
- Pages
- 9-12
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2032266026
- Cited by
- 58
- References
- 18
- Citations by year
- 2023: 1 · 2022: 1 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ventral pallidum, amphetamine, conditioned place preference, drug reward, NMDA lesions, nucleus accumbens
- MeSH terms
- Analysis of Variance, Animals, Brain Mapping, Conditioning, Operant, Dextroamphetamine, Globus Pallidus, Male, Reward, N-Methylaspartate, Rats
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