The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat
Abstract
The hypothesis that the ventral pallidum is an important site mediating psychomotor stimulant and opiate reinforcement was tested in rats trained to self-administer i.v. cocaine or heroin. Ibotenic acid lesions of the ventral pallidum produced significant decreases in cocaine and heroin self-administration behavior maintained on a fixed-ratio 5 schedule of reinforcement, suggesting an attenuation of the reinforcing value of cocaine and heroin. On a progressive-ratio schedule, ventral pallidal lesions produced significant decreases in the highest ratio obtained in rats self-administering cocaine. Similar results were observed with heroin in a progressive-ratio procedure modified to produce higher levels of responding; lesions of the ventral pallidum produced a significant decrease in the highest ratio obtained. Further, the i.v. co-administration of naloxone and heroin produced a decrease in progressive-ratio responding relative to heroin alone using the modified progressive-ratio schedule. These results suggest that the ventral pallidum is an important site mediating the reinforcing effects of cocaine and heroin and that the nucleus accumbens-ventral pallidum circuit may be a common pathway for both stimulant and opiate reinforcement.
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Based on animal studies, the role of opioids in the positive reinforcing effects of natural rewards and drugs of abuse has largely been attributed to MOR in the nucleus accumbens, ventral pallidum, and VTA, though some part is also played by DOR.
“Based on animal studies, the role of opioids in the positive reinforcing effects of natural rewards and drugs of abuse has largely been attributed to MOR in the NAC, VP, and VTA, though some part is also played by DOR (van Ree and de Wied 1980; Shippenberg et al 1987; Hubner and Koob 1990; Olmstead and Franklin 1997a; Corrigall et al 2000; Pecina and Berridge 2000; Van Ree et al 2000; Gerrits et”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Hubner and Koob 1990
Excitotoxic lesions of the vicinity of the medial ventral pallidum appear to attenuate the rewarding effects of intravenous administration of cocaine or heroin.
“Moreover, excitotoxic lesions of the vicinity of the medial ventral pallidum appear to attenuate the rewarding effects of intravenous administration of cocaine or heroin (Hubner and Koob, 1990).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Hubner and Koob, 1990
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- Authors
- Hubner, C. B., & Koob, G. F.
- Affiliations
- Scripps Clinic (US)
- Corresponding author
- Koob, George F.
- ORCID
- Koob, George F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 508
- Issue
- 1
- Pages
- 20-29
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2083322780
- Cited by
- 218
- References
- 36
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 9
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7f32da005292-03)
- National Institute on Drug Abuse (DA04043, DA05292, DA04398, R01DA004398, R01DA004043)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- ventral pallidum, cocaine self-administration, heroin self-administration, drug reinforcement, progressive ratio responding, fixed-ratio schedules, naloxone
- MeSH terms
- Animals, Behavior, Animal, Cocaine, Heroin, Globus Pallidus, Male, Rats, Inbred Strains, Reinforcement Schedule, Self Administration, Rats
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