Ventral pallidum roles in reward and motivation

Smith, Kyle S.; Tindell, Amy J.; Aldridge, J. Wayne; Berridge, Kent C.

doi:10.1016/j.bbr.2008.09.038

Cited by 548Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Ventral pallidum roles in reward and motivation

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Smith, Kyle S., Tindell, Amy J., Aldridge, J. Wayne, Berridge, Kent C.·2009·Behavioural Brain Research

DOI 10.1016/j.bbr.2008.09.038PMC PMC2606924

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Abstract

In recent years the ventral pallidum has become a focus of great research interest as a mechanism of reward and incentive motivation. As a major output for limbic signals, the ventral pallidum was once associated primarily with motor functions rather than regarded as a reward structure in its own right. However, ample evidence now suggests that ventral pallidum function is a major mechanism of reward in the brain. We review data indicating that (1) an intact ventral pallidum is necessary for normal reward and motivation, (2) stimulated activation of ventral pallidum is sufficient to cause reward and motivation enhancements, and (3) activation patterns in ventral pallidum neurons specifically encode reward and motivation signals via phasic bursts of excitation to incentive and hedonic stimuli. We conclude that the ventral pallidum may serve as an important 'limbic final common pathway' for mesocorticolimbic processing of many rewards.

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These subclusters point to neuron types shared between regions that differ in behavioral function and connectivity.
“Several subclusters (2–15, 2–21, and 2–18) expressed markers in the VP and bordering GPe (Figure 6D,E), suggesting neuron types shared across regions with different behavioral functions and connectivity (Gittis et al., 2014; Kita, 2007; Smith et al., 2009).”
From Molecular diversity and specializations among the cells of the adult mouse brain (2018) · cites this paper as Smith et al., 2009

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A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
The feeling of what happens: body and emotion in the making of consciousness
(2000) · Choice Reviews Online · doi:10.5860/choice.37-6553 · Cited by 5,998 · see citing works
Handbook of Affective Sciences
(2002) · doi:10.1093/oso/9780195126013.001.0001 · Cited by 5,104 · see citing works
The Integrative Action of the Nervous System.
Sherrington, C. (1907) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-190734120-00021 · Cited by 4,136 · see citing works
The Feeling of What Happens: Body and Emotion in the Making of Consciousness
Panksepp, J., & Modell, A. H. (2000) · Neuropsychoanalysis · doi:10.1080/15294145.2000.10773287 · Cited by 3,421 · see citing works
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176 · see citing works
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Self-citation
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works
Masked Presentations of Emotional Facial Expressions Modulate Amygdala Activity without Explicit Knowledge
Whalen, P. J., Rauch, S. L., Etcoff, N. L., McInerney, S. C., Lee, M. B., & Jenike, M. A. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00411.1998 · Cited by 2,205 · see citing works
The Integrative Action of the Nervous System
Smith, W. (1907) · Nature · doi:10.1038/076122a0 · Cited by 2,082 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901 · see citing works
Self-citation
Progress in Psychobiology and Physiological Psychology
Fluharty, S. J., & Grill, H. J. (2003) · Progress in psychobiology and physiological psychology · doi:10.1108/s0363-0951200318 · Cited by 1,701 · see citing works
Motivation concepts in behavioral neuroscience
Berridge, K. C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.004 · Cited by 1,302 · see citing works
Self-citation
Selected Writings of John Hughlings Jackson
SCOTT, J. (1959) · American Journal of Psychiatry · doi:10.1176/ajp.116.5.479-a · Cited by 1,301 · see citing works
Efferent connections of the parabrachial nucleus in the rat
Saper, C. B., & Loewy, A. D. (1980) · Brain Research · doi:10.1016/0006-8993(80)91117-8 · Cited by 1,217 · see citing works
The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90568-1 · Cited by 1,203 · see citing works
Hypothalamic control of food intake in rats and cats.
Anand, B. K., & Brobeck, J. R. (1951) · PubMed · Cited by 1,197 · see citing works
Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106 · see citing works
The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
McFarland, K., & Kalivas, P. W. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08655.2001 · Cited by 905 · see citing works
The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions.
Teitelbaum, P., & Epstein, A. N. (1962) · Psychological Review · doi:10.1037/h0039285 · Cited by 884 · see citing works
Widespread reward-system activation in obese women in response to pictures of high-calorie foods
Stoeckel, L. E., Weller, R. E., Cook, E. W., Twieg, D. B., Knowlton, R. C., & Cox, J. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.031 · Cited by 857 · see citing works
Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement
Wyvell, C. L., & Berridge, K. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08122.2000 · Cited by 764 · see citing works
Self-citation
Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward
Kelley, A. E., Baldo, B. A., Pratt, W. E., & Will, M. J. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.066 · Cited by 752 · see citing works
Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates.
Steiner, J. E., Glaser, D., Hawilo, M. E., & Berridge, K. C. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00051-8 · Cited by 752 · see citing works
Self-citation
How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements
Bindra, D. (1978) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00059380 · Cited by 732 · see citing works
Multiple neural systems controlling food intake and body weight
Berthoud, H.-R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00014-3 · Cited by 725 · see citing works
Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns
Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works
Self-citation
Pleasures of the brain
Berridge, K. C. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00014-9 · Cited by 694 · see citing works
Self-citation
Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis
Bigl, V., Woolf, N. J., & Butcher, L. L. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90101-0 · Cited by 691 · see citing works
Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?
Peciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Self-citation
How the Brain Translates Money into Force: A Neuroimaging Study of Subliminal Motivation
Pessiglione, M., Schmidt, L., Draganski, B., Kalisch, R., Lau, H., Dolan, R. J., & Frith, C. D. (2007) · Science · doi:10.1126/science.1140459 · Cited by 634 · see citing works
Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene.
Lim, M. M., Wang, Z., Olazábal, D. E., Ren, X., Terwilliger, E. F., & Young, L. J. (2004) · Nature · doi:10.1038/nature02539 · Cited by 628 · see citing works
Individual Differences in Reward Drive Predict Neural Responses to Images of Food
Beaver, J. D., Lawrence, A. D., van Ditzhuijzen, J., Davis, M. H., Woods, A., & Calder, A. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0350-06.2006 · Cited by 594 · see citing works
The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats
Grill, H. J., & Norgren, R. (1978) · Brain Research · doi:10.1016/0006-8993(78)90569-3 · Cited by 588 · see citing works
HOW THE BRAIN PROCESSES SOCIAL INFORMATION: Searching for the Social Brain
Insel, T. R., & Fernald, R. D. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144148 · Cited by 556 · see citing works
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09395.2003 · Cited by 551 · see citing works
Self-citation
Opioid modulation of taste hedonics within the ventral striatum
Kelley, A. E., Bakshi, V. P., Haber, S. N., Steininger, T. L., Will, M. J., & Zhang, M. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00751-5 · Cited by 526 · see citing works
Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
McFarland, K., Davidge, S. B., Lapish, C. C., & Kalivas, P. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-03.2004 · Cited by 524 · see citing works
Cellular Mechanisms of Social Attachment
Young, L. J., Lim, M. M., Gingrich, B., & Insel, T. R. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1691 · Cited by 523 · see citing works
An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens
Zahm, D. S. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00065-2 · Cited by 487 · see citing works
Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C] raclopride study in healthy men
Leyton, M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00366-4 · Cited by 476 · see citing works
The basal forebrain-cortical cholinergic system: interpreting the functional consequences of excitotoxic lesions
Dunnett, S. B., Everitt, B. J., & Robbins, T. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90061-x · Cited by 460 · see citing works
Organization of the output of the ventral striatopallidal system in the rat: ventral pallidal efferents
Groenewegen, H. J., Berendse, H. W., & Haber, S. N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90115-v · Cited by 456 · see citing works
Opioid modulation of appetite
Morley, J. E., Levine, A. S., Yim, G. K. W., & Lowy, M. T. (1983) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(83)90020-9 · Cited by 453 · see citing works
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., Wong, C., Gatley, S. J., Gifford, A. N., Ding, Y., et al. (2002) · Synapse · doi:10.1002/syn.10075 · Cited by 452 · see citing works
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum
Smith, K. S., & Berridge, K. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4205-06.2007 · Cited by 450 · see citing works
Self-citation
Hedonic Hot Spots in the Brain
Peciña, S., Smith, K. S., & Berridge, K. C. (2006) · The Neuroscientist · doi:10.1177/1073858406293154 · Cited by 441 · see citing works
Self-citation
Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered “Wanting” for Sucrose Reward
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436 · see citing works
Self-citation
Efferent connections of the ventral pallidum: Evidence of a dual striato pallidofugal pathway
Haber, S. N., Groenewegen, H. J., Grove, E. A., & Nauta, W. J. H. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350304 · Cited by 432 · see citing works
Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward-learning network
Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1478-05.2005 · Cited by 429 · see citing works
The topographic order of inputs to nucleus accumbens in the rat
Phillipson, O. T., & Griffiths, A. C. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90002-8 · Cited by 415 · see citing works
Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat
Mogenson, G. J., Swanson, L. W., & Wu, M. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-01-00189.1983 · Cited by 410 · see citing works
Two transpallidal pathways originating in the rat nucleus accumbens
Zahm, D. S., & Heimer, L. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903020302 · Cited by 406 · see citing works
GABA in the Nucleus Accumbens Shell Participates in the Central Regulation of Feeding Behavior
Stratford, T. R., & Kelley, A. E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04434.1997 · Cited by 404 · see citing works
Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste “liking”/“disliking” reactions, place preference/avoidance, and fear
Reynolds, S. M., & Berridge, K. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07308.2002 · Cited by 403 · see citing works
Self-citation
Ventral striatum and ventral pallidum
Heimer, L., Switzer, R. D., & Hoesen, G. W. V. (1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90037-6 · Cited by 401 · see citing works
Prelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues
Childress, A. R., Ehrman, R. N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. G., Jens, W., Suh, J. J., Listerud, J., Marquez, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001506 · Cited by 395 · see citing works
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Self-citation
Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377 · see citing works
Self-citation
Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS
Mansour, A., Fox, C. A., Burke, S., Akil, H., & Watson, S. J. (1995) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(95)00055-c · Cited by 370 · see citing works
The limbic lobe and its output channels: implications for emotional functions and adaptive behavior
Heimer, L., & Van Hoesen, G. W. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.006 · Cited by 366 · see citing works
GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area
Kalivas, P. W., Churchill, L., & Klitenick, M. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90048-k · Cited by 353 · see citing works
Glutamate systems in cocaine addiction
Kalivas, P. W. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.11.002 · Cited by 349 · see citing works
Neurobiology of 50-kHz ultrasonic vocalizations in rats: Electrode mapping, lesion, and pharmacology studies
Burgdorf, J. S., Wood, P. L., Kroes, R. A., Moskal, J. R., & Panksepp, J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.010 · Cited by 347 · see citing works
The Concepts of the Ventral Striatopallidal System and Extended Amygdala
de Olmos, J. S., & Heimer, L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09258.x · Cited by 343 · see citing works
Sources of presumptive glutamergic/aspartergic afferents to the rat ventral striatopallidal region
Fuller, T. A., Russchen, F. T., & Price, J. L. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580302 · Cited by 342 · see citing works
The Psychology of Learning and Motivation
(2009) · The Psychology of learning and motivation/The psychology of learning and motivation · doi:10.1016/c2009-0-01769-3 · Cited by 341 · see citing works
Neural systems for behavioral activation and reward
Kalivas, P. W., & Nakamura, M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80031-2 · Cited by 335 · see citing works
Extended Amygdala and Basal Forebrain
Alheid, G. F. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07082.x · Cited by 334 · see citing works
Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistry
Haber, S. N., & Nauta, W. J. H. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90291-9 · Cited by 325 · see citing works
Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole
Lim, M. M., & Young, L. J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.008 · Cited by 322 · see citing works
Reward learning: reinforcement, incentives, and expectations
Berridge, K. C. (2000) · Psychology of Learning and Motivation · doi:10.1016/s0079-7421(00)80022-5 · Cited by 318 · see citing works
Self-citation
What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?
Berridge, K. C., & Valenstein, E. S. (1991) · Behavioral Neuroscience · doi:10.1037//0735-7044.105.1.3 · Cited by 302 · see citing works
Self-citation
What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?
Berridge, K. C., & Valenstein, E. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.3 · Cited by 302 · see citing works
Self-citation
Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07392.2001 · Cited by 295 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Substantia innominata: a notion which impedes clinical–anatomical correlations in neuropsychiatric disorders
Heimer, L., Harlan, R. E., Alheid, G. F., Garcia, M. M., & de Olmos, J. S. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00405-8 · Cited by 286 · see citing works
Neural associations of the substantia innominata in the rat: Afferent connections
Grove, E. A. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770302 · Cited by 281 · see citing works
Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior
Reynolds, S. M., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03261.2001 · Cited by 281 · see citing works
Self-citation
Connections of the subthalamic nucleus with ventral striatopallidal parts of the basal ganglia in the rat
Groenewegen, H. J., & Berendse, H. W. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902940408 · Cited by 279 · see citing works
Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine
Tindell, A. J., Berridge, K. C., Zhang, J., Peciña, S., & Aldridge, J. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04411.x · Cited by 268 · see citing works
Self-citation
Basal forebrain cholinergic lesions disrupt increments but not decrements in conditioned stimulus processing
Chiba, A., Bucci, D., Holland, P., & Gallagher, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07315.1995 · Cited by 257 · see citing works
Sodium depletion enhances salt palatability in rats
Berridge, K. C., Flynn, F. W., Schulkin, J., & Grill, H. J. (1984) · Behavioral Neuroscience · doi:10.1037/0735-7044.98.4.652 · Cited by 257 · cited 1× · see citing works
“Ventral pallidum neurons thus pass the most stringent test for hedonic coding that is dis-confounded from sensory coding: being able to track hedonic shifts of a single sensory stimulus from nasty to pleasant [116,175,180,181].”
Self-citation
Differential effects of two ways of devaluing the unconditioned stimulus after Pavlovian appetitive conditioning.
Holland, P. C., & Straub, J. J. (1979) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.5.1.65 · Cited by 254 · see citing works
Alterations in feeding and drinking behavior of rats with lesions in globi pallidi
Morgane, P. J. (1961) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1961.201.3.420 · Cited by 252 · see citing works
Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study
Usuda, I., Tanaka, K., & Chiba, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00359-x · Cited by 248 · see citing works
Ventral pallidum firing codes hedonic reward: when a bad taste turns good
Tindell, A. J., Smith, K. S., Peciña, S., Berridge, K. C., & Aldridge, J. W. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00576.2006 · Cited by 241 · see citing works
Self-citation
The Contribution of Basal Forebrain to Limbic — Motor Integration and the Mediation of Motivation to Action
Mogenson, G. J., & Yang, C. R. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_14 · Cited by 238 · see citing works
Nucleus Accumbens μ-Opioids Regulate Intake of a High-Fat Diet via Activation of a Distributed Brain Network
Will, M. J., Franzblau, E. B., & Kelley, A. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02882.2003 · Cited by 223 · see citing works
Efferent connections of the substantia innominata in the rat
Grove, E. A. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902770303 · Cited by 222 · see citing works
Cortical input to the basal forebrain
Záborszky, L., Gaykema, R. P. A., Swanson, D. J., & Cullinan, W. E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00049-3 · Cited by 221 · see citing works
Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?
Cromwell, H. C., & Berridge, K. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90053-p · Cited by 220 · see citing works
Self-citation
Recovery from the Failure to Eat Produced by Hypothalamic Lesions
Teitelbaum, P., & Stellar, E. (1954) · Science · doi:10.1126/science.120.3126.894 · Cited by 216 · see citing works
The ventral striatopallidal parts of the basal ganglia in the rat—II. Compartmentation of ventral pallidal efferents
Zahm, D. S. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90351-5 · Cited by 211 · see citing works
Ventral striatopallidal parts of the basal ganglia in the rat: I. Neurochemical compartmentation as reflected by the distributions of neurotensin and substance P immunoreactivity
Zahm, D. S., & Heimer, L. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902720406 · Cited by 199 · see citing works
Excitotoxic lesions of basal forebrain cholinergic neurons: Effects on learning, memory and attention
Muir, J. L., Page, K. J., Sirinathsinghji, D. J. S., Robbins, T. W., & Everitt, B. J. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90128-d · Cited by 199 · see citing works
Evidence for the coexistence of glutamate decar☐ylase and Met-enkephalin immunoreactivities in axon terminals of rat ventral pallidum
Zahm, D. S., Záborszky, L., Alones, V., & Heimer, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90331-2 · Cited by 196 · see citing works
Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes.
Bakshi, V. P., & Kelley, A. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38247-9 · Cited by 193 · see citing works
Neural systems recruited by drug- and food-related cues: Studies of gene activation in corticolimbic regions
Kelley, A. E., Schiltz, C. A., & Landry, C. F. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.06.018 · Cited by 193 · see citing works
Separable Substrates for Anticipatory and Consummatory Food Chemosensation
Small, D. M., Veldhuizen, M. G., Felsted, J. A., Mak, Y. E., & McGlone, F. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.021 · Cited by 190 · see citing works
SOME OBSERVATIONS ON THE BUCCO‐PHARYNGEAL STAGE OF REFLEX DEGLUTITION IN THE CAT
Miller, F. R., & Sherrington, C. (1915) · Quarterly journal of experimental physiology · doi:10.1113/expphysiol.1915.sp000201 · Cited by 184 · see citing works
The effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on the acquisition and retention of a conditional visual discrimination: Implications for cholinergic hypotheses of learning and memory
Everitt, B. J., Robbins, T. W., Evenden, J. L., Marston, H. M., Jones, G. H., & Sirkiä, T. E. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90346-0 · Cited by 182 · see citing works
Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum
Klitenick, M. A., Deutch, A. Y., Churchill, L., & Kalivas, P. W. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90430-a · Cited by 182 · see citing works
Endogenous opioids and feeding behavior: a 30-year historical perspective
Bodnar, R. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.01.006 · Cited by 170 · see citing works
Efferent connections of dorsal and ventral agranular insular cortex in the hamster, Mesocricetus auratus
Reep, R. L., & Winans, S. S. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90087-2 · Cited by 169 · see citing works
Ventral striatopallidal oxytocin and vasopressin V1a receptors in the monogamous prairie vole (<i>Microtus ochrogaster</i>)
Lim, M. M., Murphy, A. Z., & Young, L. J. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10973 · Cited by 163 · see citing works
Disgust sensitivity predicts the insula and pallidal response to pictures of disgusting foods.
Calder, A. J., Beaver, J. D., Davis, M. H., Van Ditzhuijzen, J., Keane, J., & Lawrence, A. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05604.x · Cited by 154 · see citing works
Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo
Maidment, N. T., Brumbaugh, D. R., Rudolph, V. D., Erdelyi, E., & Evans, C. J. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90407-7 · Cited by 151 · see citing works
Time course of the development of behavioral sensitization and dopamine receptor up-regulation during binge cocaine administration.
Unterwald, E. M., Ho, A., Rubenfeld, J. M., & Kreek, M. J. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22549-6 · Cited by 149 · see citing works
Cocaine-Induced Reinstatement Requires Endogenous Stimulation of μ-Opioid Receptors in the Ventral Pallidum
Tang, X., McFarland, K., Cagle, S., & Kalivas, P. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0685-05.2005 · Cited by 148 · see citing works
Acquisition of sodium by rats: Interaction of innate mechanisms and latent learning.
Krieckhaus, E. E., & Wolf, G. (1968) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025547 · Cited by 138 · see citing works
Light microscopic autoradiographic localization of mu and delta opioid binding sites in the mouse central nervous system
Moskowitz, A. S., & Goodman, R. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-05-01331.1984 · Cited by 135 · see citing works
Projections of the Parabrachial Nucleus in the Old World Monkey
Pritchard, T. C., Hamilton, R. B., & Norgren, R. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7450 · Cited by 134 · see citing works
Conditioned place preference and locomotor activation produced by injection of psychostimulants into ventral pallidum
Gong, W., Neill, D. B., & Justice, J. B. (1996) · Brain Research · doi:10.1016/0006-8993(95)01222-2 · Cited by 134 · see citing works
Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat
Cooper, S. J. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90247-2 · Cited by 133 · see citing works
The globus pallidus and its rostroventral extension into the olfactory tubercle of the rat: A cyto- and chemoarchitectural study
Switzer, R. C., Hill, J., & Heimer, L. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90005-7 · Cited by 131 · see citing works
Morphine enhances hedonic taste palatability in rats
Doyle, T. G., Berridge, K. C., & Gosnell, B. A. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90572-b · Cited by 131 · see citing works
Self-citation
Neural activation during sexual and competitive arousal in healthy men
Rauch, S. L., Shin, L. M., Dougherty, D. D., Alpert, N. M., Orr, S. P., Lasko, M. C., Macklin, M. L., Fischman, A. J., & Pitman, R. K. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00020-7 · Cited by 130 · see citing works
Effects of medial dorsal thalamic and ventral pallidal lesions on the acquisition of a conditioned place preference: Further evidence for the involvement of the ventral striatopallidal system in reward-related processes
McAlonan, G. M., Robbins, T. W., & Everitt, B. J. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90410-h · Cited by 129 · see citing works
The evolving theory of basal forebrain functional—anatomical ‘macrosystems’
Zahm, D. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.003 · Cited by 128 · see citing works
The hedonic impact and intake of food are increased by midazolam microinjection in the parabrachial nucleus
Gordh, A. S., & Berridge, K. C. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02691-3 · Cited by 128 · see citing works
Self-citation
Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes
Tindell, A. J., Berridge, K. C., & Aldridge, J. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1437-03.2004 · Cited by 128 · see citing works
Self-citation
Palatability shift of a salt-associated incentive during sodium depletion.
Berridge, K. C., & Schulkin, J. A. (1989) · PubMed · Cited by 127 · see citing works
Self-citation
Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat
Robledo, P., & Koob, G. F. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90112-4 · Cited by 127 · see citing works
Sources of presumptive glutamatergic/aspartatergic afferents to the magnocellular basal forebrain in the rat
Carnes, K., Fuller, T. A., & Price, J. (1990) · The Journal of comparative neurology · doi:10.1002/cne.903020413 · Cited by 127 · see citing works
Neurochemical regulation of pair bonding in male prairie voles
Wang, Z., & Aragona, B. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.024 · Cited by 125 · see citing works
Involvement of the Pallidal‐thalamocortical Circuit in Adaptive Behavior
Kalivas, P. W., Churchill, L., & ROMANIDES, A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09261.x · Cited by 120 · see citing works
Anhedonia After a Selective Bilateral Lesion of the Globus Pallidus
Miller, J. M., Vorel, S. R., Tranguch, A. J., Kenny, E. T., Mazzoni, P., van Gorp, W. G., & Kleber, H. D. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.5.786 · Cited by 120 · see citing works
Cannabinoid Modulation of Opiate Reinforcement through the Ventral Striatopallidal Pathway
Caillé, S., & Parsons, L. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300848 · Cited by 118 · see citing works
On emotional expression after decortication with some remarks on certain theoretical views: Part II.
Bard, P. (1934) · Psychological Review · doi:10.1037/h0071731 · Cited by 118 · see citing works
Hedonic Hotspots: Generating Sensory Pleasure in the Brain
Smith, K. S., Mahler, S. V., Peciña, S., & Berridge, K. C. (2009) · Oxford University Press eBooks · doi:10.1093/oso/9780195331028.003.0003 · Cited by 117 · see citing works
Self-citation
Anatomical and Electrophysiological Evidence for an Excitatory Amino Acid Pathway from the Thalamic Mediodorsal Nucleus to the Prefrontal Cortex in the Rat
Pirot, S., Jay, T. M., Glowinski, J., & Thierry, A. M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00621.x · Cited by 116 · see citing works
Two types of aphagia and two types of sensorimotor impairment after lateral hypothalamic lesions: Observations in normal weight, dieted, and fattened rats.
Schallert, T. J., & Whishaw, I. Q. (1978) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077504 · Cited by 116 · see citing works
Neural correlates of pair-bonding in a monogamous primate
Bales, K. L., Mason, W. A., Catana, C., Cherry, S. R., & Mendoza, S. P. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.087 · Cited by 112 · see citing works
The amygdala is critical for opioid-mediated binge eating of fat
Will, M. J., Franzblau, E. B., & Kelley, A. E. (2004) · Neuroreport · doi:10.1097/00001756-200408260-00004 · Cited by 111 · see citing works
A topographically organized gamma‐aminobutyric acid projection from the ventral pallidum to the nucleus accumbens in the rat
Churchill, L., & Kalivas, P. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450408 · Cited by 110 · see citing works
The ventral striatopallidothalamic projection: II. The ventral pallidothalamic link
Zahm, D. S., Záborszky, L., Alheid, G. F., & Heimer, L. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902550410 · Cited by 108 · see citing works
Opioid Modulation of Ventral Pallidal Inputs
Napier, T. C., & Mitrovic, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09268.x · Cited by 106 · see citing works
Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats
Stratford, T. R., Kelley, A. E., & Simansky, K. J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01239-1 · Cited by 105 · see citing works
Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior
Farrar, A. M., Font, L., Pereira, M., Mingote, S., Bunce, J. G., Chrobak, J. J., & Salamone, J. D. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.12.034 · Cited by 103 · see citing works
Neurochemical modulation of ingestive behavior in the ventral pallidum
Shimura, T., Imaoka, H., & Yamamoto, T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04689.x · Cited by 102 · see citing works
6-Hydroxydopamine lesion of ventral pallidum blocks acquisition of place preference conditioning to cocaine
Gong, W., Neill, D. B., & Justice, J. B. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00059-0 · Cited by 100 · see citing works
SENSORY AFFECT AND MOTIVATION*
Pfaffmann, C., & Norgren, R. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb39713.x · Cited by 100 · see citing works
Nicotinic receptor‐mediated regulation of dopamine transporter activity in rat prefrontal cortex
Drew, A. E., Derbez, A. E., & Werling, L. L. (2000) · Synapse · doi:10.1002/1098-2396(200010)38:1 · Cited by 93 · see citing works
The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum
June, H. L., Foster, K. L., McKay, P. F., Seyoum, R., Woods, J. E., Harvey, S. C., Eiler, W. J. A., Grey, C., Carroll, M. R., McCane, S., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300239 · Cited by 91 · see citing works
Presynaptic Versus Postsynaptic Localization of μ and δ Opioid Receptors in Dorsal and Ventral Striatopallidal Pathways
Olive, M. F., Antón, B., Micevych, P. E., Evans, C. J., & Maidment, N. T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07471.1997 · Cited by 89 · see citing works
Position of the ventral pallidum in the rat prefrontal cortex–basal ganglia circuit
Maurice, N., Deniau, J., Menetrey, A., Glowinski, J., & Thierry, A. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00002-x · Cited by 89 · see citing works
Different Roles for Amygdala Central Nucleus and Substantia Innominata in the Surprise-Induced Enhancement of Learning
Holland, P. C., & Gallagher, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0390-06.2006 · Cited by 85 · see citing works
Prominent Activation of Brainstem and Pallidal Afferents of the Ventral Tegmental Area by Cocaine
Geisler, S., Marinelli, M., DeGarmo, B., Becker, M. L., Freiman, A. J., Beales, M., Meredith, G. E., & Zahm, D. S. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301650 · Cited by 84 · see citing works
Regional reward differences within the ventral pallidum are revealed by microinjections of a mu opiate receptor agonist
Johnson, P. I., Stellar, J. R., & Paul, A. D. (1993) · Neuropharmacology · doi:10.1016/0028-3908(93)90025-x · Cited by 81 · see citing works
Effects of the opioid antagonist naltrexone on feeding induced by DAMGO in the ventral tegmental area and in the nucleus accumbens shell region in the rat
MacDonald, A. F., Billington, C. J., & Levine, A. S. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00271.2003 · Cited by 80 · see citing works
Opioid and GABA modulation of accumbens-evoked ventral pallidal activity
Chrobak, J. J., & Napier, T. C. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245342 · Cited by 78 · see citing works
The mediodorsal nucleus of the thalamus in rats—I. Forebrain gabaergic innervation
Churchill, L., Zahm, D. S., & Kalivas, P. W. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00351-i · Cited by 77 · see citing works
The GABAAReceptor α1Subtype in the Ventral Pallidum Regulates Alcohol-Seeking Behaviors
Harvey, S. C., Foster, K. L., McKay, P. F., Carroll, M. R., Seyoum, R., Woods, J. E., Grey, C., Jones, C. M., McCane, S., Cummings, R., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03765.2002 · Cited by 77 · see citing works
The central extended amygdala network as a proposed circuit underlying reward valuation
Waraczynski, M. A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.09.001 · Cited by 75 · see citing works
Ventral pallidum self-stimulation: a moveable electrode mapping study
Panagis, G., Miliaressis, E., Anagnostakis, Y., & Spyraki, C. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00169-g · Cited by 75 · see citing works
GABAergic control of basal forebrain cholinergic neurons and memory
Dudchenko, P. A., & Sarter, M. F. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80037-3 · Cited by 73 · see citing works
Striatal and ventral pallidum dynorphin concentrations are markedly increased in human chronic cocaine users
Frankel, P. S., Alburges, M. E., Bush, L. G., Hanson, G. R., & Kish, S. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.019 · Cited by 72 · see citing works
Amphetamine lowers extracellular GABA concentration in the ventral pallidum
Bourdelais, A. J., & Kalivas, P. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)90907-s · Cited by 69 · see citing works
Control of appetitive and aversive taste-reactivity responses by an auditory conditioned stimulus in a devaluation task: A FOS and behavioral analysis
Kerfoot, E. C., Agarwal, I., Lee, H. J., & Holland, P. C. (2007) · Learning & Memory · doi:10.1101/lm.627007 · Cited by 68 · see citing works
Ventral pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward-related brain regions
Panagis, G., Nomikos, G. G., Miliaressis, E., Chergui, K., Kastellakis, A., Svensson, T. H., & Spyraki, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00471-x · Cited by 66 · see citing works
Sensory preconditioning of flavors with a formalin-produced sodium need.
Fudim, O. K. (1978) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037//0097-7403.4.3.276 · Cited by 65 · see citing works
Regulation of Limbic Information Outflow by the Subthalamic Nucleus: Excitatory Amino Acid Projections to the Ventral Pallidum
Turner, M. S., Lavı́n, A., Grace, A. A., & Napier, T. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02820.2001 · Cited by 63 · see citing works
The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus–reward associations
Rademacher, D. J., Kovacs, B., Shen, F., Napier, T. C., & Meredith, G. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05066.x · Cited by 63 · see citing works
Electrophysiological Properties of Cholinergic and Noncholinergic Neurons in the Ventral Pallidal Region of the Nucleus Basalis in Rat Brain Slices
Bengtson, C. P., & Osborne, P. B. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2649 · Cited by 63 · see citing works
Effects of excitotoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on visual discrimination acquisition, performance and reversal in the rat
Evenden, J. L., Marston, H. M., JONES, G., Giardini, V., Lénárd, L., Everitt, B. J., & Robbins, T. W. (1989) · Behavioural Brain Research · doi:10.1016/s0166-4328(89)80080-4 · Cited by 62 · see citing works
Effects of excitotoxic lesions of the basal forebrain on MFB self-stimulation
Arvanitogiannis, A. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02157-4 · Cited by 60 · see citing works
A bi-directional μ-opioid–opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat
Kim, E., Quinn, J. G., Levine, A. S., & O‘Hare, E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.001 · Cited by 60 · see citing works
Involvement of pallidothalamic circuitry in working memory
Kalivas, P. W., Jackson, D., Romanidies, A., Wyndham, L., & Duffy, P. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00054-9 · Cited by 58 · see citing works
Morphine enhancement of sucrose palatability: Analysis by the taste reactivity test
Rideout, H. J., & Parker, L. A. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02077-2 · Cited by 58 · see citing works
The ventral pallidum area is involved in the acquisition but not expression of the amphetamine conditioned place preference
Hiroi, N., & White, N. M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90426-l · Cited by 58 · see citing works
Approach and withdrawal analysis of the effects of hypothalamic stimulation and lesions in rats.
Stellar, J. R., Brooks, F. H., & Mills, L. E. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077590 · Cited by 57 · see citing works
Physiological properties of rat ventral pallidal neurons recorded intracellularly in vivo
Lavı́n, A., & Grace, A. A. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1432 · Cited by 55 · see citing works
Blockade of ventral pallidal opioid receptors induces a conditioned place aversion and attenuates acquisition of cocaine place preference in the rat
Skoubis, P. D., & Maidment, N. T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00121-0 · Cited by 54 · see citing works
Brainstem systems mediate the enhancement of palatability by chlordiazepoxide
Berridge, K. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)91128-6 · Cited by 52 · see citing works
Self-citation
Substance P attenuates and DAMGO potentiates amygdala glutamatergic neurotransmission within the ventral pallidum
Mitrovic, I., & Napier, T. C. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00130-9 · Cited by 52 · see citing works
Sensory preconditioning of flavors with a formalin-produced sodium need.
Fudim, O. K. (1978) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.4.3.276 · Cited by 51 · see citing works
Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders
Berridge, K. C. (2007) · Elsevier eBooks · doi:10.1016/b978-012370633-1/50008-6 · Cited by 48 · see citing works
Self-citation
GABA‐ and Glutamate‐evoked Responses in the Rat Ventral Pallidum are Modulated by Dopamine
Johnson, P. I., & Napier, T. C. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01494.x · Cited by 48 · see citing works
Intravenous heroin self‐administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats
Caillé, S., & Parsons, L. H. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03497.x · Cited by 48 · see citing works
Is Dopamine a Neurotransmitter within the Ventral Pallidum/Substantia Innominata?
Napier, T. C., Muench, M. B., Maslowski, R. J., & Battaglia, G. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_9 · Cited by 44 · see citing works
Comparison of delta opiate receptor agonist induced reward and motor effects between the ventral pallidum and dorsal striatum
Johnson, P. I., & Stellar, J. R. (1994) · Neuropharmacology · doi:10.1016/s0028-3908(05)80007-3 · Cited by 44 · see citing works
Reciprocal opioid–opioid interactions between the ventral tegmental area and nucleus accumbens regions in mediating μ agonist-induced feeding in rats
Bodnar, R. J., Lamonte, N., Israel, Y., Kandov, Y., Ackerman, T. F., & Khaimova, E. (2004) · Peptides · doi:10.1016/j.peptides.2004.11.007 · Cited by 44 · see citing works
Electrophysiological evidence for reciprocal connectivity between the nucleus accumbens septi and ventral pallidal region
Hakan, R. L., Berg, G. I., & Henriksen, S. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90730-w · Cited by 43 · see citing works
Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems
Robbins, T. W. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90067-0 · Cited by 42 · see citing works
Emotional and motivational changes after bilateral lesions of the globus pallidus.
Vijayaraghavan, L., Vaidya, J. G., Humphreys, C. T., Beglinger, L. J., & Paradiso, S. (2008) · Neuropsychology · doi:10.1037/0894-4105.22.3.412 · Cited by 42 · see citing works
Changes in Accumbal and Pallidal pCREB and ΔFosB in Morphine-Sensitized Rats: Correlations with Receptor-Evoked Electrophysiological Measures in the Ventral Pallidum
McDaid, J., Dallimore, J. E., Mackie, A. R., & Napier, T. C. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300854 · Cited by 40 · see citing works
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA
Torregrossa, M. M., Tang, X.-C., & Kalivas, P. W. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.016 · Cited by 38 · see citing works
Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring rats
Smith, D. G., Learn, J. E., McBride, W. J., Lumeng, L., Li, T., & Murphy, J. M. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00553-6 · Cited by 36 · see citing works
Repeated pre-exposure to morphine into the ventral pallidum enhances morphine-induced place preference: Involvement of dopaminergic and opioidergic mechanisms
Zarrindast, M., Ebrahimi-Ghiri, M., Rostami, P., & Rezayof, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.019 · Cited by 35 · see citing works
Nullifying drug-induced sensitization: Behavioral and electrophysiological evaluations of dopaminergic and serotonergic ligands in methamphetamine-sensitized rats
McDaid, J., Tedford, C. E., Mackie, A. R., Dallimore, J. E., Mickiewicz, A. L., Shen, F., Angle, J. M., & Napier, T. C. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.05.014 · Cited by 35 · see citing works
Cross-Sensitization to Morphine in Cocaine-Sensitized Rats: Behavioral Assessments Correlate with Enhanced Responding of Ventral Pallidal Neurons to Morphine and Glutamate, with Diminished Effects of GABA
McDaid, J., Dallimore, J. E., Mackie, A. R., Mickiewicz, A. L., & Napier, T. C. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.084038 · Cited by 34 · see citing works
Intra-ventral pallidal glutamate antagonists block expression of morphine-induced place preference.
Dallimore, J. E., Mickiewicz, A. L., & Napier, T. C. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.5.1103 · Cited by 33 · see citing works
Opioid Regulation of Pallidal Enkephalin Release: Bimodal Effects of Locally Administered Mu and Delta Opioid Agonists in Freely Moving Rats
Olive, M. F., & Maidment, N. T. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37536-6 · Cited by 32 · see citing works
Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release
Olive, M. F., Bertolucci, M., Evans, C. J., & Maidment, N. T. (1995) · Neuroreport · doi:10.1097/00001756-199505300-00005 · Cited by 30 · see citing works
The role of the ventral pallidum GABAergic system in conditioned taste aversion: Effects of microinjections of a GABAA receptor antagonist on taste palatability of a conditioned stimulus
Inui, T., Shimura, T., & Yamamoto, T. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.031 · Cited by 30 · see citing works

Flagged first, then by citations

2 of the 223 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

[1]Heimer L Wilson RD Santini M The subcortical projections of allocortex: similarities in the neural associations of the hippocampus, the periform cortex and the neocortex Golgi centennial symposium proceedings New York Raven Press 1975 173 93
[71]Panksepp J Strongman K Affective Neuroscience: A Conceptual Framework for the Study of Emotions International reviews of studies in emotions Chichester Wiley 1991 59 99
[175]Aldridge JW Berridge KC Kringelbach ML Berridge KC Neural Coding of Pleasure: “Rose-Tinted Glasses” of the Ventral Pallidum Pleasures of the Brain Oxford, U.K Oxford University Press in press
[184]Toates FM Motivational Systems Cambridge Cambridge University Press 1986

Sorted by citations

Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942 · see citing works
Self-citation
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Saunders, A., Macosko, E. Z., Wysoker, A., Goldman, M., Krienen, F. M., de Rivera, H., Bien, E., Baum, M., Bortolin, L., Wang, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.028 · Cited by 1,847 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
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Self-citation
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O'Connell, L. A., & Hofmann, H. A. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22735 · Cited by 986 · see citing works
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Knab, A. M., & Lightfoot, J. T. (2010) · International Journal of Biological Sciences · doi:10.7150/ijbs.6.133 · Cited by 140 · see citing works
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Self-citation
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Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat.
Faure, A., Richard, J. M., & Berridge, K. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011223 · Cited by 114 · see citing works
Self-citation
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Burger, K. S., & Stice, E. M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.066 · Cited by 109 · see citing works
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Merz, E. C., He, X., & Noble, K. G. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.07.020 · Cited by 108 · see citing works
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Hjelmstad, G. O., Xia, Y., Margolis, E. B., & Fields, H. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0178-13.2013 · Cited by 106 · see citing works
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Perry, D. C., Sturm, V. E., Seeley, W. W., Miller, B. L., Kramer, J. H., & Rosen, H. J. (2014) · Brain · doi:10.1093/brain/awu075 · Cited by 104 · see citing works
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Peciña, S., & Smith, K. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.016 · Cited by 104 · see citing works
Self-citation
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Roberson, E. D. (2012) · Annals of Neurology · doi:10.1002/ana.23722 · Cited by 97 · see citing works
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Li, Y., Luo, Y., Xu, W., Ge, J., Chérasse, Y., Wang, Y., Lazarus, M., Qu, W., & Huang, Z. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00906-0 · Cited by 94 · see citing works
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Ottenheimer, D. J., Bari, B. A., Sutlief, E., Fraser, K. M., Kim, T. H., Richard, J. M., Cohen, J. Y., & Janak, P. H. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0688-5 · Cited by 81 · see citing works
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Miller, A. H., Jones, J. F., Drake, D. F., Tian, H., Unger, E. R., & Pagnoni, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098156 · Cited by 92 · see citing works
The Basal Ganglia
Haber, S. N., Adler, A., & Bergman, H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10020-3 · Cited by 90 · see citing works
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Soares‐Cunha, C., Coimbra, B., Domingues, A. V., de Vasconcelos, N. A. P., Sousa, N., & Rodrigues, A. J. (2018) · eNeuro · doi:10.1523/eneuro.0386-18.2018 · Cited by 92 · see citing works
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Ji, M., Zhang, X., Chen, Z., Wang, J.-J., & Zhu, J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0127-0 · Cited by 87 · see citing works
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Cilia, R., & van Eimeren, T. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0314-0 · Cited by 86 · see citing works
Affective and sensorimotor components of emotional prosody generation.
Pichon, S., & Kell, C. A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3530-12.2013 · Cited by 86 · see citing works
Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone
Bach, P., Weil, G., Pompili, E., Hoffmann, S., Hermann, D., Vollstädt‐Klein, S., Mann, K. F., Pérez‐Ramírez, Ú., Moratal, D., Canals, S., et al. (2019) · Addiction Biology · doi:10.1111/adb.12717 · Cited by 85 · see citing works
Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood
Fonzo, G. A., Ramsawh, H. J., Flagan, T., Simmons, A. N., Sullivan, S. G., Allard, C. B., Paulus, M. P., & Stein, M. B. (2015) · Psychological Medicine · doi:10.1017/s0033291715002603 · Cited by 85 · see citing works
Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms
Farrell, M. R., Schoch, H., & Mahler, S. V. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.002 · Cited by 85 · see citing works
Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium
Schijven, D., Postema, M. C., Fukunaga, M., Matsumoto, J., Miura, K., de Zwarte, S. M. C., van Haren, N. E. M., Cahn, W., Pol, H. E. H., Kahn, R. S., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213880120 · Cited by 83 · see citing works
Is comfort food really comforting? Mechanisms underlying stress-induced eating
Pool, E. R., Delplanque, S., Coppin, G., & Sander, D. (2015) · Food Research International · doi:10.1016/j.foodres.2014.12.034 · Cited by 80 · see citing works
Intrauterine Growth Restriction and the Fetal Programming of the Hedonic Response to Sweet Taste in Newborn Infants
Ayres, C., Agranonik, M., Portella, A. K., Filion, F., Johnston, C. C., & Silveira, P. P. (2012) · International Journal of Pediatrics · doi:10.1155/2012/657379 · Cited by 81 · see citing works
Pharmacokinetic, behavioral, and brain activity effects of Δ9-tetrahydrocannabinol in adolescent male and female rats
Ruiz, C. M., Torrens, A., Castillo, E., Perrone, C. R., Cevallos, J. R., Inshishian, V. C., Harder, E. V., Justeson, D. N., Huestis, M. A., Swarup, V., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00839-w · Cited by 79 · see citing works
Altered hypothalamic response to food in smokers
Geha, P., Aschenbrenner, K., Felsted, J. A., O’Malley, S. S., & Small, D. M. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.043307 · Cited by 80 · see citing works
The Functional and Neurobiological Properties of Bad Taste
Schier, L. A., & Spector, A. C. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2017 · Cited by 75 · see citing works
Nucleus accumbens cytoarchitecture predicts weight gain in children
Rapuano, K. M., Laurent, J. S., Hagler, D. J., Hatton, S. N., Thompson, W. K., Jernigan, T. L., Dale, A. M., Casey, B. J., & Watts, R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007918117 · Cited by 79 · see citing works
On lateral septum‐like characteristics of outputs from the accumbal hedonic “hotspot” of Peciña and Berridge with commentary on the transitional nature of basal forebrain “boundaries”
Zahm, D. S., Parsley, K. P., Schwartz, Z. M., & Cheng, A. Y. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23157 · Cited by 76 · see citing works
Oxytocin, Dopamine, and Opioid Interactions Underlying Pair Bonding: Highlighting a Potential Role for Microglia
Loth, M. K., & Donaldson, Z. R. (2020) · Endocrinology · doi:10.1210/endocr/bqaa223 · Cited by 74 · see citing works
The effects of high-intensity exercise on neural responses to images of food
Crabtree, D. R., Chambers, E. S., Hardwick, R. M., & Blannin, A. K. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071381 · Cited by 75 · see citing works
Treatment-resistant depression: molecular mechanisms and management
Kajumba, M. M., Kakooza‐Mwesige, A., Nakasujja, N., Attix, D. K., & Canli, T. (2024) · Molecular Biomedicine · doi:10.1186/s43556-024-00205-y · Cited by 86 · see citing works
Imaging Social Motivation: Distinct Brain Mechanisms Drive Effort Production during Collaboration versus Competition
Bouc, R. L., & Pessiglione, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0143-13.2013 · Cited by 72 · see citing works
Neuronal pathways linking substance P to drug addiction and stress
Commons, K. G. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.014 · Cited by 74 · see citing works
Central vasopressin V1a receptor activation is independently necessary for both partner preference formation and expression in socially monogamous male prairie voles
Donaldson, Z. R., Spiegel, L., & Young, L. J. (2010) · Behavioral Neuroscience · doi:10.1037/a0018094 · Cited by 71 · see citing works
Motivational competition and the paraventricular thalamus
McNally, G. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.021 · Cited by 74 · see citing works
Reward for food odors: an fMRI study of liking and wanting as a function of metabolic state and BMI
Jiang, T., Soussignan, R., Schaal, B., & Royet, J. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu086 · Cited by 70 · see citing works
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation
Bo, K., Kraynak, T. E., Kwon, M., Sun, M. M. C., Gianaros, P. J., & Wager, T. D. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01605-7 · Cited by 69 · see citing works

Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure
Richard, J. M., Stout, N., Acs, D., & Janak, P. H. (2018) · eLife · doi:10.7554/elife.33107 · Cited by 44 · see citing works
Signaling Incentive and Drive in the Primate Ventral Pallidum for Motivational Control of Goal-Directed Action
Fujimoto, A., Hori, Y., Nagai, Y., Kikuchi, E., Oyama, K., Suhara, T., & Minamimoto, T. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2399-18.2018 · Cited by 58 · see citing works
Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions
Richard, J. M., Ambroggi, F., Janak, P. H., & Fields, H. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.037 · Cited by 142 · see citing works
The Ventral Pallidum as an Orchestrator of Reward-Seeking Behavior
Creed, M. C. (2026) · Addiction Neuroscience · doi:10.1016/j.addicn.2026.100274
Coding of rewarded tasks by ventral pallidum neurons: Learning, hedonics, and incentive value.
Tindell, A. J. (2005) · Deep Blue (University of Michigan)
Self-citation

Authors: Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C.
Affiliations: McGovern Institute for Brain Research (US)
University of Michigan (US)
Corresponding author: Smith, Kyle S.
ORCID: Smith, Kyle S.
Aldridge, J. Wayne
Berridge, Kent C.
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 2009-01
Volume: 196
Issue: 2
Pages: 155-167
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/j.bbr.2008.09.038
PMC: PMC2606924
OpenAlex: W2124103130
Cited by: 548
References: 223
Citations by year: 2026: 22 · 2025: 29 · 2024: 47 · 2023: 39 · 2022: 40 · 2021: 41 · 2020: 33 · 2019: 43 · 2018: 31 · 2017: 23 · 2016: 27 · 2015: 35 · 2014: 23 · 2013: 29 · 2012: 28
FWCI: 1.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (MH-63649, R01MH063649)
National Institute on Drug Abuse (R01DA017752, DA-017752, DA015188, R01DA015188)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: ventral pallidum, reward, incentive motivation, limbic system, mesocorticolimbic pathway, neuronal firing patterns, reward encoding
MeSH terms: Analgesics, Opioid, Animals, Eating, Globus Pallidus, Humans, Motivation, Neural Pathways, Neurons, Nucleus Accumbens, Reward, Sex, GABA Antagonists

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Ventral pallidum roles in reward and motivation

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