Cited by 374Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

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Synaptic and neuritic alterations during the progression of Alzheimer's disease

Masliah, Eliezer, Mallory, Margaret, Hansen, Lawrence, Richard, DeTeresa, Alford, Michael, Terry, Robert·1994·Neuroscience Letters

DOI 10.1016/0304-3940(94)90121-x

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Abstract

Extensive synaptic and neuritic alterations in the neocortex and limbic system are characteristically found in Alzheimer's disease (AD). However, it is not known how early in the development of the disease these alterations occur. For the present study, we compared the synaptic and neuritic alterations among cases classified clinically and neuropathologically as early, mild and advanced AD. In early AD there was a 20% loss of synaptophysin-immunoreactive presynaptic terminals in the outer molecular layer of the hippocampal dentate gyrus (but not in the neocortex and entorhinal cortex), accompanied by increased amyloid precursor protein (APP) and Alz50 immunoreactivity in hippocampal and entorhinal cortex pyramidal neurons. These results suggest that abnormal neuronal expression of APP and cytoskeletal proteins in early stages might be involved in the mechanisms of synaptic pathology in AD.

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Authors: Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R.
Affiliations: University of California San Diego (US)
Corresponding author: Masliah, Eliezer
ORCID: Masliah, Eliezer
Hansen, Lawrence
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1994-06
Volume: 174
Issue: 1
Pages: 67-72
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(94)90121-x
OpenAlex: W2073518622
Cited by: 370
References: 30
Citations by year: 2026: 1 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 15 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 14 · 2014: 11 · 2013: 15 · 2012: 18
FWCI: 4.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag008205-08, 5r01ag008201-05)
National Institute on Aging (AG 08205, AG05131, P50AG005131, AG08201)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, synaptic pathology, synaptophysin, presynaptic terminals, amyloid precursor protein, amyloid plaques, dentate gyrus, entorhinal cortex, hippocampus, pyramidal neurons, cytoskeletal proteins, disease progression
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Cerebral Cortex, Cytoskeleton, Hippocampus, Humans, Nerve Tissue Proteins, Synapses, Neurites, Synaptophysin, Pyramidal Cells, Entorhinal Cortex

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Synaptic and neuritic alterations during the progression of Alzheimer's disease

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