Cited by 374Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Synaptic and neuritic alterations during the progression of Alzheimer's disease

Masliah, Eliezer, Mallory, Margaret, Hansen, Lawrence, Richard, DeTeresa, Alford, Michael, Terry, Robert·1994·Neuroscience Letters

DOI 10.1016/0304-3940(94)90121-x

Open this paper in CoChat — free account

Abstract

Extensive synaptic and neuritic alterations in the neocortex and limbic system are characteristically found in Alzheimer's disease (AD). However, it is not known how early in the development of the disease these alterations occur. For the present study, we compared the synaptic and neuritic alterations among cases classified clinically and neuropathologically as early, mild and advanced AD. In early AD there was a 20% loss of synaptophysin-immunoreactive presynaptic terminals in the outer molecular layer of the hippocampal dentate gyrus (but not in the neocortex and entorhinal cortex), accompanied by increased amyloid precursor protein (APP) and Alz50 immunoreactivity in hippocampal and entorhinal cortex pyramidal neurons. These results suggest that abnormal neuronal expression of APP and cytoskeletal proteins in early stages might be involved in the mechanisms of synaptic pathology in AD.

Integrity signals

Registry

Crossref · 10.1016/0304-3940(94)90121-x

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397
Self-citation
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376
Analysis of Messy Data
Milliken, G. A., & Johnson, D. E. (1992) · Thammasat University Digital Collections · Cited by 1,469
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801
Self-citation
Perforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer’s disease
Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638
Clinico‐pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586

Show all 30 references

Sorted by citations

Items 101–200 of 374

Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
Mulder, M., Jansen, P. J., Janssen, B. J. A., van de Berg, W. D. J., van der Boom, H., Havekes, L. M., de Kloet, R. E., Ramaekers, F. C. S., & Blokland, A. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.015 · Cited by 98
Tau-mediated synaptic damage in Alzheimer’s disease
Jadhav, S., Cubinkova, V., Zimova, I., Brezováková, V., Maďari, A., Cigánková, V., & Žilka, N. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0023 · Cited by 97
Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity
Weinstock, M., & Shoham, S. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0058-y · Cited by 97
Astroglial Activation of Extracellular-Regulated Kinase in Early Stages of Alzheimer Disease
Webster, B., Hansen, L. A., Adame, A., Crews, L. A., Torrance, M., Thal, L. J., & Masliah, E. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000199599.63204.6f · Cited by 94
Self-citation
SUMO and Alzheimer’s Disease
Lee, L., Sakurai, M., Matsuzaki, S., Arancio, O., & Fraser, P. E. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8257-7 · Cited by 94
Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer’s disease
Leshchyns’ka, I., Liew, H. T., Shepherd, C. E., Halliday, G. M., Stevens, C. H., Ke, Y. D., Ittner, L. M., & Sytnyk, V. (2015) · Nature Communications · doi:10.1038/ncomms9836 · Cited by 94
GABAergic Deafferentation Hypothesis of Brain Aging and Alzheimer’s Disease Revisited
Marczynski, T. J. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00347-x · Cited by 91
Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain
Arendt, T. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00216-5 · Cited by 91
The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases
Breuer, M. E., Koopman, W. J. H., Koene, S., Nooteboom, M., Rodenburg, R. J., Willems, P. H. G. M., & Smeitink, J. A. M. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.007 · Cited by 87
Coenzyme Q10 reduces sevoflurane-induced cognitive deficiency in young mice
Xu, G., Han, L., Dong, Y., Shapoval, D., Soriano, S. G., Liu, X., Zhang, Y., & Xie, Z. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex071 · Cited by 85
Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment
Giau, V. V., Bagyinszky, E., & An, S. S. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174149 · Cited by 85
Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model
Griñán‐Ferré, C., Marsal-García, L., Bellver‐Sanchís, A., Kondengaden, S. M., Turaga, R. C., Vázquez, S., & Pallàs, M. (2019) · Aging · doi:10.18632/aging.102558 · Cited by 85
Aβ plaques
Walker, L. C. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3025 · Cited by 113
Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice
Blanchard, J., Wanka, L., Tung, Y.-C., Cárdenas-Aguayo, M. D. C., LaFerla, F. M., Iqbal, K., & Grundke-Iqbal, I. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0734-6 · Cited by 85
Sevoflurane Acts on Ubiquitination–Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice
Han, L., Liufu, N., Dong, Y., Xu, G., Zhang, Y., Shu, L., Soriano, S. G., Zheng, H., Yu, B., & Xie, Z. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001889 · Cited by 81
Sex differences in synaptic plasticity in stress-responsive brain regions following chronic variable stress
de Carvalho-Netto, E. F., Myers, B., Jones, K., Solomon, M. B., & Herman, J. P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.024 · Cited by 77
Apolipoprotein E enhances uptake of soluble but not aggregated amyloid‐β protein into synaptic terminals
Gylys, K. H., Fein, J. A., Tan, A. M., & Cole, G. M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01643.x · Cited by 70
Cycles of Aberrant Synaptic Sprouting and Neurodegeneration in Alzheimer's and Dementia with Lewy Bodies
Hashimoto, M., & Masliah, E. (2003) · Neurochemical Research · doi:10.1023/a:1026073324672 · Cited by 78
Self-citation
The dentate gyrus in Alzheimer's disease
Ohm, T. G. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63039-8 · Cited by 78
New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles
Unsain, N., & Barker, P. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.029 · Cited by 77
Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
Echeverría, V., & Cuello, A. C. (2002) · Molecular Neurobiology · doi:10.1385/mn:26:2-3:299 · Cited by 81
Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease
Castranio, E. L., Hasel, P., Haure‐Mirande, J., Ramirez Jimenez, A. V., Hamilton, B. W., Kim, R. D., Glabe, C. G., Wang, M., Zhang, B., Gandy, S., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12821 · Cited by 74
“21,60,62 Assessment of the impact of intervening with SHIP1 modulation at a range of disease stages will be critical in determining whether boosting or inhibiting SHIP1 activity is most likely to lead to a meaningful clinical benefit in patients at high risk for, or already suffering from, the…”
Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine
Savvateeva, E. V., Popov, A. V., Камышев, Н. Г., Bragina, J. V., Heisenberg, M., Senitz, D., Kornhuber, J., & Riederer, P. F. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070080 · Cited by 74
Mapping cellular transcriptosomes in autopsied Alzheimer's disease subjects and relevant animal models
Reddy, P. H., & McWeeney, S. K. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.04.014 · Cited by 73
Characterization of perforant path lesions in rodent models of memory and attention
Kirkby, D. L., & Higgins, G. A. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00087.x · Cited by 74
High-resolution 7T fMRI of Human Hippocampal Subfields during Associative Learning
Suthana, N., Donix, M., Wozny, D. R., Bazih, A., Jones, M., Heidemann, R. M., Trampel, R., Ekstrom, A. D., Scharf, M., Knowlton, B. J., et al. (2014) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00772 · Cited by 75
Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease
Chauhan, N. B. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300010-jlr200 · Cited by 64
Redox proteomics identification of oxidatively modified proteins in Alzheimer's disease brain and in vivo and in vitro models of AD centered around Aβ(1–42)☆
Rukhsana Sultana, A., Marzia Perluigi, A., & Butterfield, D. A. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.09.024 · Cited by 72
Leptin signaling and Alzheimer's disease.
Marwarha, G., & Ghribi, O. (2012) · Europe PMC (PubMed Central) · Cited by 73
Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor
Bellizzi, M. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25444 · Cited by 69
New Perspectives on Alzheimer’s Disease and Nutrition
Gustafson, D., Morris, M. C., Scarmeas, N., Shah, R. C., Sijben, J., Yaffe, K. S., & Zhu, X. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150084 · Cited by 71
Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice
Boncristiano, S., Calhoun, M. E., Howard, V., Bondolfi, L., Kaeser, S. A., Wiederhold, K.-H., Staufenbiel, M., & Jucker, M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.010 · Cited by 68
Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
Arendt, T. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00007-7 · Cited by 66
Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology.
Shiurba, R., Ishiguro, K., Takahashi, M., Sato, K., Spooner, E. T., Mercken, M., Yoshida, R., Wheelock, T. R., Yanagawa, H., Imahori, K., et al. (1996) · Brain Research · doi:10.1016/0006-8993(96)00717-2 · Cited by 69
Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer’s disease
Riise, J., Plath, N., Pakkenberg, B., & Parachikova, A. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1375-7 · Cited by 66
Impairments of glutamatergic synaptic transmission in Alzheimer’s disease
Zott, B., & Konnerth, A. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.013 · Cited by 66
Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer’s Disease via Peroxisome Proliferator-Activated Receptor α
Chandra, S., & Pahan, K. (2019) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-190104 · Cited by 68
Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice
Cambon, K., Davies, H. A., & Stewart, M. G. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00065-8 · Cited by 63
Growth-associated protein 43 (GAP-43) and synaptophysin alterations in the dentate gyrus of patients with schizophrenia
Chambers, J. S., Thomas, D., Saland, L. C., Neve, R. L., & Perrone‐Bizzozero, N. I. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.013 · Cited by 62
Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride
Hou, Y., Zhou, L., Yang, Q. D., Du, X., Li, M., Yuan, M., & Zhou, Z. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.030 · Cited by 64
GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease
Audoy-Rémus, J., Bozoyan, L., Dumas, A., Filali, M., Lecours, C., Lacroix, S., Rivest, S., Tremblay, M., & Vallières, L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.01.010 · Cited by 63
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals
Hark, T. J., Rao, N. R., Castillon, C., Basta, T., Smukowski, S. N., Bao, H., Upadhyay, A., Bomba-Warczak, E. K., Nomura, T., O'Toole, E. T., et al. (2020) · Cell Systems · doi:10.1016/j.cels.2020.11.007 · Cited by 60
Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease
Mecca, A. P., Chen, M.-K., O’Dell, R. S., Naganawa, M., Toyonaga, T., Godek, T. A., Harris, J. E., Bartlett, H. H., Zhao, W., Banks, E. R., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.11.004 · Cited by 60
Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions
Alber, J., Bouwman, F. H., den Haan, J., Rissman, R. A., Groef, L. D., Koronyo‐Hamaoui, M., Lengyel, I., & Thal, D. R. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13529 · Cited by 64
The response of synaptophysin and microtubule‐associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine
Xu, H., He, J., Richardson, J. S., & Li, X. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02827.x · Cited by 61
CD8+ T Cell-Mediated Mechanisms Contribute to the Progression of Neurocognitive Impairment in Both Multiple Sclerosis and Alzheimer's Disease?
Stojić-Vukanić, Z., Hadžibegović, S., Nicole, O., Nacka-Aleksić, M., Leštarević, S., & Leposavić, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.566225 · Cited by 68
Dysregulated protein phosphorylation: A determining condition in the continuum of brain aging and Alzheimer's disease
Ferrer, I., Andrés‐Benito, P., Ausín, K., Pamplona, R., del Río, J. A., Fernández‐Irigoyen, J., & Santamaría, E. (2021) · Brain Pathology · doi:10.1111/bpa.12996 · Cited by 61
Caffeoylquinic Acid-Rich Purple Sweet Potato Extract, with or without Anthocyanin, Imparts Neuroprotection and Contributes to the Improvement of Spatial Learning and Memory of SAMP8 Mouse
Sasaki, K., Han, J., Shimozono, H., Villareal, M. O., & Isoda, H. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3041484 · Cited by 60
Apolipoprotein E and Alzheimer's Disease: A Review of Recent Studies
Higgins, G. A., Large, C. H., Rupniak, H. T., & Barnes, J. C. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00420-0 · Cited by 58
Anesthesia/Surgery Induces Cognitive Impairment in Female Alzheimer’s Disease Transgenic Mice
Zhang, C., Zhang, Y., Shen, Y., Zhao, G., Xie, Z., & Dong, Y. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161268 · Cited by 59
siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo
Hérard, A., Besret, L., Dubois, A., Dauguet, J., Delzescaux, T., Hantraye, P., Bonvento, G., & Moya, K. L. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.020 · Cited by 61
Evidence for recovery of spatial learning following entorhinal cortex lesions in mice
Hardman, R., Evans, D. J., Fellows, L. A., Hayes, B., Rupniak, H. T., Barnes, J., & Higgins, G. A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00223-0 · Cited by 57
PET Imaging for Early Detection of Alzheimer’s Disease
Bao, W., Jia, H., Finnema, S. J., Cai, Z., Carson, R. E., & Huang, Y. H. (2017) · PET Clinics · doi:10.1016/j.cpet.2017.03.001 · Cited by 54
Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease
Buchanan, H. M., Mackay, M., PALMER, K., Tothová, K., Katsur, M., Platt, B., & Koss, D. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01950-1 · Cited by 58
Neuronal-Based Synaptic Compensation: A Computational Study in Alzheimer's Disease
Horn, D., Levy, N., & Ruppin, E. (1996) · Neural Computation · doi:10.1162/neco.1996.8.6.1227 · Cited by 52
Reversal of amyloid β toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid β antibody
Chauhan, N. B., & Siegel, G. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10286 · Cited by 53
Structural basis of dementia in neurodegenerative disorders
Jellinger, K. A. (1996) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6892-9_1 · Cited by 54
The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s disease
Iwai, A., Masliah, E., Sundsmo, M. P., DeTeresa, R. M., Mallory, M. E., Salmon, D. P., & Saitoh, T. (1996) · Brain Research · doi:10.1016/0006-8993(96)00014-5 · Cited by 51
Self-citation
γ-Oryzanol Improves Cognitive Function and Modulates Hippocampal Proteome in Mice
Rungratanawanich, W., Cenini, G., Mastinu, A., Sylvester, M., Wilkening, A., Abate, G., Bonini, S. A., Aria, F., Marziano, M., Maccarinelli, G., et al. (2019) · Nutrients · doi:10.3390/nu11040753 · Cited by 52
Molecular and cellular mediators of Alzheimer's disease inflammation
Strohmeyer, R., & Rogers, J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3118 · Cited by 52
Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia
Merluzzi, A. P., Carlsson, C. M., Johnson, S. C., Schindler, S. E., Asthana, S., Blennow, K., Zetterberg, H., & Bendlin, B. B. (2018) · Neurology · doi:10.1212/wnl.0000000000005901 · Cited by 49
Development of a new treatment for alzheimer’s disease and parkinson’s disease using anti-aggregatory β-synuclein-derived peptides
Windisch, M., Hutter‐Paier, B., Rockenstein, E. M., Hashimoto, M., Mallory, M. E., & Masliah, E. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0012-8 · Cited by 49
Self-citation
Modification of Hippocampal Markers of Synaptic Plasticity by Memantine in Animal Models of Acute and Repeated Restraint Stress: Implications for Memory and Behavior
Amin, S. N., El-Aidi, A. A., Ali, M. M., Attia, Y. M., & Rashed, L. A. (2015) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8343-0 · Cited by 49
Endothelin receptor antagonists: Potential in Alzheimer's disease
Palmer, J. C., & Love, S. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.12.008 · Cited by 49
Regional and Gender Study of Neuronal Density in Brain during Aging and in Alzheimer's Disease
Martínez‐Pinilla, E., Ordóñez, C., del Valle, E., Navarro, A., & Tolivia, J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00213 · Cited by 49
Opportunities and challenges in developing Alzheimer disease therapeutics
Iqbal, K., & Grundke, I. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0878-z · Cited by 48
Mechanisms of synaptic pathology in Alzheimer’s disease
Masliah, E. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_13 · Cited by 46
Self-citation
β-amyloid: The known unknowns
Ayton, S., & Bush, A. I. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101212 · Cited by 45
Selective vulnerability of different types of commissural neurons for amyloid -protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology
Capetillo-Zarate, E., Staufenbiel, M., Abramowski, D., Haass, C., Escher, A., Stadelmann, C., Yamaguchi, H., Wiestler, O. D., & Thal, D. R. (2006) · Brain · doi:10.1093/brain/awl176 · Cited by 45
Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease
Tiwari, S. S., d’Orange, M., Troakes, C., Shurovi, B. N., Engmann, O., Noble, W. J., Hortobágyi, T., & Giese, K.-P. (2015) · Molecular Brain · doi:10.1186/s13041-015-0096-z · Cited by 47
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
Chan, S. L., Furukawa, K., & Mattson, M. P. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:167 · Cited by 45
Alterations in glutamate receptor 2/3 subunits and amyloid precursor protein expression during the course of Alzheimer’s disease and Lewy body variant
Thorns, V., Mallory, M. E., Hansen, L. A., & Masliah, E. (1997) · Acta Neuropathologica · doi:10.1007/s004010050748 · Cited by 43
Self-citation
The Role of Synaptic Proteins in Alzheimer's Disease
Masliah, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05562.x · Cited by 39
Self-citation
Dietary Lipids in the Aetiology of Alzheimer???s Disease
Cooper, J. L. (2003) · Drugs & Aging · doi:10.2165/00002512-200320060-00001 · Cited by 40
Alzheimer’s Disease: Understanding Motor Impairments
Andrade-Guerrero, J., Martínez-Orozco, H., Villegas-Rojas, M. M., Santiago-Balmaseda, A., Delgado-Minjares, K. M., Pérez‐Segura, I., Baéz-Cortés, M. T., Toro-Colín, M. A. D., Guerra‐Crespo, M., Arias-Carrión, Ó., et al. (2024) · Brain Sciences · doi:10.3390/brainsci14111054 · Cited by 53
In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease
Reggiani, A. M., Simoni, E., Caporaso, R., Meunier, J., Keller, E., Maurice, T., Minarini, A., Rosini, M., & Cavalli, A. (2016) · Scientific Reports · doi:10.1038/srep33172 · Cited by 40
Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets
Brokaw, D. L., Piras, I. S., Mastroeni, D., Weisenberger, D. J., Nolz, J., Delvaux, E., Serrano, G. E., Beach, T. G., Huentelman, M. J., & Coleman, P. D. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.06.022 · Cited by 38
Synapses, Microglia, and Lipids in Alzheimer’s Disease
Paasila, P. J., Aramideh, J. A., Sutherland, G. T., & Graeber, M. B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.778822 · Cited by 40
Locally reduced levels of acidic FGF lead to decreased expression of 28‐kDa calbindin and contribute to the selective vulnerability of the neurons in the entorhinal cortex in Alzheimer's disease
Thorns, V., Licastro, F., & Masliah, E. (2001) · Neuropathology · doi:10.1046/j.1440-1789.2001.00399.x · Cited by 38
Self-citation
Neuroendocrine plasticity in GnRH release during rat estrous cycle: correlation with molecular markers of synaptic remodeling
Kaur, G., Heera, P. K., & Srivastava, L. K. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03301-2 · Cited by 38
NMDA receptors mediate synaptic depression, but not spine loss in the dentate gyrus of adult amyloid Beta (Aβ) overexpressing mice
Müller, M., Jacobi, E., Sakimura, K., Malinow, R., & von Engelhardt, J. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0611-4 · Cited by 40
Biomarkers: Our Path Towards a Cure for Alzheimer Disease
Tarawneh, R. M. (2020) · Biomarker Insights · doi:10.1177/1177271920976367 · Cited by 42
Redox proteomics in some age-related neurodegenerative disorders or models thereof
Butterfield, D. A., Abdul, H. M., Newman, S. F., & Reed, T. T. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.05.003 · Cited by 37
Macrophages Relate Presynaptic and Postsynaptic Damage in Simian Immunodeficiency Virus Encephalitis
Bissel, S. J., Wang, G., Ghosh, M., Reinhart, T. A., Capuano, S., Cole, K. S., Murphey‐Corb, M., Piatak, M., Lifson, J. D., & Wiley, C. A. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64915-2 · Cited by 37
Perinatal Programming of Neurodevelopment: Epigenetic Mechanisms and the Prenatal Shaping of the Brain
Desplats, P. (2014) · Advances in neurobiology · doi:10.1007/978-1-4939-1372-5_16 · Cited by 37
Protecting the Synapse: Evidence for a Rational Strategy to Treat HIV-1 Associated Neurologic Disease
Bellizzi, M. J., Lu, S., & Gelbard, H. A. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-005-9006-y · Cited by 37
Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production
Zoltowska, K. M., Maesako, M., Lushnikova, I., Takeda, S., Keller, L. J., Skibo, G., Hyman, B. T., & Berezovska, O. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0159-y · Cited by 36
A Peephole into the Brain: Neuropathological Features of Alzheimer’s Disease Revealed by in vivo Two-Photon Imaging
Liebscher, S., & Meyer‐Luehmann, M. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00026 · Cited by 36
Aberrant Presenilin-1 Expression Downregulates LDL Receptor-Related Protein (LRP): Is LRP Central to Alzheimer's Disease Pathogenesis?
Van Uden, E., Carlson, G., St. George-Hyslop, P., Westaway, D., Orlando, R., Mallory, M., Rockenstein, E., & Masliah, E. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0772 · Cited by 32
Self-citation
GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease
Bozoyan, L., Audoy-Rémus, J., Dumas, A., Filali, M., Lacroix, S., Rivest, S., Tremblay, M., & Vallières, L. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.08.351 · Cited by 36
The Double-Edged Flower: Roles of Complement Protein C1q in Neurodegenerative Diseases
Tenner, A. J., & Fonseca, M. I. (2007) · Springer eBooks · doi:10.1007/0-387-34134-x_11 · Cited by 33
Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease
Chen, S., Wang, T., Yao, J., & Brinton, R. D. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00874-x · Cited by 34
Age-related synapse loss in hippocampal CA3 is not reversed by caloric restriction
Adams, M. M., Donohue, H. S., Linville, M. C., Iversen, E., Newton, I. G., & Brunso-Bechtold, J. K. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.022 · Cited by 36
Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy
Wakabayashi, K., Hansen, L. A., Vincent, I. J., Mallory, M. E., & Masliah, E. (1997) · Acta Neuropathologica · doi:10.1007/s004010050576 · Cited by 33
Self-citation
Antenatal betamethasone treatment reduces synaptophysin immunoreactivity in presynaptic terminals in the fetal sheep brain
Antonow‐Schlorke, I., Kühn, B., Müller, T. H., Schubert, H., Sliwka, U., Nathanielsz, P. W., & Schwab, M. G. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01605-0 · Cited by 32
CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue
Woelfle, S., Deshpande, D., Feldengut, S., Braak, H., Tredici, K. D., Roselli, F., Deisseroth, K. A., Michaelis, J., Boeckers, T. M., & Schön, M. (2023) · BMC Biology · doi:10.1186/s12915-023-01582-6 · Cited by 35
T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice
Fukushima, T., Nakamura, A., Iwakami, N., Nakada, Y., Hattori, H., Hoki, S., Yamaguchi, H., Nakagawa, M., Terashima, N., & Narita, H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.03.091 · Cited by 31
Aβ25–35 induces presynaptic changes in organotypic hippocampal slice cultures
Suh, E. C., Jung, Y. J., Kim, Y. A., Park, E., & Lee, K. E. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.04.001 · Cited by 34
Abnormal Population Responses in the Somatosensory Cortex of Alzheimer’s Disease Model Mice
Maatuf, Y., Stern, E. A., & Slovin, H. (2016) · Scientific Reports · doi:10.1038/srep24560 · Cited by 34
Proteomics Analysis in Alzheimer's Disease: New Insights into Mechanisms of Neurodegeneration
Butterfield, D. A., & Debra Boyd-kimball, A. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)61007-5 · Cited by 31

Authors: Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R.
Affiliations: University of California San Diego (US)
Corresponding author: Masliah, Eliezer
ORCID: Masliah, Eliezer
Hansen, Lawrence
Venue: Neuroscience Letters
Publisher: Elsevier BV
Published: 1994-06
Volume: 174
Issue: 1
Pages: 67-72
ISSN: 0304-3940 (ISSN-L)
DOI: 10.1016/0304-3940(94)90121-x
OpenAlex: W2073518622
Cited by: 370
References: 30
Citations by year: 2026: 1 · 2025: 10 · 2024: 10 · 2023: 17 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 15 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 14 · 2014: 11 · 2013: 15 · 2012: 18
FWCI: 4.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience Letters (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag008205-08, 5r01ag008201-05)
National Institute on Aging (AG 08205, AG05131, P50AG005131, AG08201)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, synaptic pathology, synaptophysin, presynaptic terminals, amyloid precursor protein, amyloid plaques, dentate gyrus, entorhinal cortex, hippocampus, pyramidal neurons, cytoskeletal proteins, disease progression
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Cerebral Cortex, Cytoskeleton, Hippocampus, Humans, Nerve Tissue Proteins, Synapses, Neurites, Synaptophysin, Pyramidal Cells, Entorhinal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Synaptic and neuritic alterations during the progression of Alzheimer's disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks