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Two types of dystrophic neurites in senile plaques of alzheimer disease and elderly non-demented cases
Abstract
Senile plaques (SPs) occur profusely in brain tissue of Alzheimer disease (AD) cases, and sparsely in brain tissue of elderly normals. Two types of dystrophic neurites (DNs) have been identified in SPs. Type 1 are the classically described elongated forms. Type 2 are globular in shape. Type 1 DNs are stained immunohistochemically by antibodies to A68 protein, other forms of phosphorylated tau, and N-terminal epitopes of amyloid precursor protein (APP), as well as an antibody which preferentially recognized conjugated ubiquitin. Type 2 DNs are stained immunohistochemically by antibodies to chromogranin A and C-terminal epitopes of APP, as well as an antibody which preferentially recognizes free ubiquitin. SPs of AD cases usually contain a mixture of type 1 and type 2 DNs. However, in the neocortex of elderly normals, which have few neurofibrillary tangles and neuropil threads, the DNs in the SPs are restricted to type 2. These data suggest that SPs containing only type 2 DNs may be benign, and independent of neurofibrillary pathology.
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Dense cored neuritic plaques are accompanied by synaptic loss, activated microglia and reactive astrocytes.
“Dense cored NPs are also accompanied by synaptic loss, activated microglia and reactive astrocytes [23, 29, 36].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [36]
Dystrophic neurites in neuritic plaques are heterogeneous.
“The dystrophic neurites in neuritic plaques are heterogeneous [36].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [36]
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“The dystrophic neurites in neuritic plaques are heterogeneous [36].”
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Metadata
- Authors
- Yasuhara, O., Kawamata, T., Aimi, Y., McGeer, E. G., & McGeer, P. L.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- McGeer, Patrick L.
- ORCID
- McGeer, Patrick L.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 171
- Issue
- 1-2
- Pages
- 73-76
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1968603129
- Cited by
- 53
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, amyloid plaques, dystrophic neurites, phosphorylated tau, amyloid precursor protein, ubiquitin, chromogranin A, neurofibrillary tangles, neuropil threads, neocortex, immunohistochemistry
- MeSH terms
- Aged, Aged, 80 and over, Aging, Alzheimer Disease, Antigens, Cerebral Cortex, Chromogranins, Fluorescent Dyes, Humans, Immunohistochemistry, Thiazoles, Ubiquitins, Neurites, Amyloid beta-Protein Precursor, tau Proteins, Benzothiazoles, Chromogranin A
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