Cited by 254Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The cause of neuronal degeneration in Alzheimer’s disease

Open access
Vickers, J·2000·Progress in Neurobiology

Abstract

Alzheimer's disease is associated with a specific pattern of pathological changes in the brain that result in neurodegeneration and the progressive development of dementia. Pathological hallmarks common to the disease include beta-amyloid plaques, dystrophic neurites associated with plaques and neurofibrillary tangles within nerve cell bodies. The exact relationship between these pathological features has been elusive, although it is clear that beta-amyloid plaques precede neurofibrillary tangles in neocortical areas. Examination of the brains of individuals in the preclinical stage of the disease have shown that the earliest form of neuronal pathology associated with beta-amyloid plaques resembles the cellular changes that follow structural injury to axons. Thus, the development of beta-amyloid plaques in the brain may cause physical damage to axons, and the abnormally prolonged stimulation of the neuronal response to this kind of injury ultimately results in the profound cytoskeletal alterations that underlie neurofibrillary pathology and neurodegeneration. Therapeutically, inhibition of the neuronal reaction to physical trauma may be a useful neuroprotective strategy in the earliest stages of Alzheimer's disease.

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Crossref · 10.1016/s0301-0082(99)00023-4

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329 of 329 references verified0 citation errors · 0 not checkable

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  • Alzheimer's disease pathology includes degeneration of neurons and loss of synapses in the cortex, hippocampus, and subcortical structures.

    “The pathology of AD manifests with degeneration of the neurons, along with loss of synapses in the cortex, the hippocampus, and the subcortical structures [12].”

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Authors
Vickers, J.
Affiliations
University of Tasmania (AU)
Corresponding author
Vickers, J
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2000-02
Volume
60
Issue
2
Pages
139-165
ISSN
0301-0082 (ISSN-L)
OpenAlex
W2111417422
Cited by
254
References
329
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 12 · 2013: 6 · 2012: 7
FWCI
12.98
Type
journal article
Language
en
Open access
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • eCite Digital Repository (University of Tasmania) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, neurodegeneration, amyloid plaques, neurofibrillary tangles, dystrophic neurites, axonal injury, cytoskeletal alterations, dementia, neuroprotection, preclinical Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Humans, Nerve Degeneration

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