The cause of neuronal degeneration in Alzheimer’s disease
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Alzheimer's disease is associated with a specific pattern of pathological changes in the brain that result in neurodegeneration and the progressive development of dementia. Pathological hallmarks common to the disease include beta-amyloid plaques, dystrophic neurites associated with plaques and neurofibrillary tangles within nerve cell bodies. The exact relationship between these pathological features has been elusive, although it is clear that beta-amyloid plaques precede neurofibrillary tangles in neocortical areas. Examination of the brains of individuals in the preclinical stage of the disease have shown that the earliest form of neuronal pathology associated with beta-amyloid plaques resembles the cellular changes that follow structural injury to axons. Thus, the development of beta-amyloid plaques in the brain may cause physical damage to axons, and the abnormally prolonged stimulation of the neuronal response to this kind of injury ultimately results in the profound cytoskeletal alterations that underlie neurofibrillary pathology and neurodegeneration. Therapeutically, inhibition of the neuronal reaction to physical trauma may be a useful neuroprotective strategy in the earliest stages of Alzheimer's disease.
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Alzheimer's disease pathology includes degeneration of neurons and loss of synapses in the cortex, hippocampus, and subcortical structures.
“The pathology of AD manifests with degeneration of the neurons, along with loss of synapses in the cortex, the hippocampus, and the subcortical structures [12].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [12]
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Does Alzheimer's disease begin in the brainstem?
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Role of the Immune System in the Pathogenesis, Prevention and Treatment of Alzheimer??s Disease
Blasko, I., & Grubeck-Loebenstein, B. (2003) · Drugs & Aging · doi:10.2165/00002512-200320020-00002 · Cited by 108 · see citing works
Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer’s disease
Saiz-Sanchez, D., De la Rosa-Prieto, C., Ubeda-Banon, I., & Martinez-Marcos, A. (2015) · Brain Structure and Function · doi:10.1007/s00429-014-0771-3 · Cited by 79 · see citing works
Schnurra, I., Bernstein, H.-G., Riederer, P., & Braunewell, K.-H. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0432 · Cited by 76 · see citing works
Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system
Vickers, J. C., King, A. E., Woodhouse, A., Kirkcaldie, M. T., Staal, J. A., McCormack, G. H., Blizzard, C. A., Musgrove, R. E. J., Mitew, S., Liu, Y., et al. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.08.004 · Cited by 69 · see citing works
Self-citationIs mitochondrial DNA depletion involved in Alzheimer's disease?
Rodríguez-Santiago, B., Casademont, J., & Nunes, V. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200629 · Cited by 57 · see citing works
Exercise-Induced Modulation of Neuroinflammation in Models of Alzheimer’s Disease
Kelly, Á. M. (2018) · Brain Plasticity · doi:10.3233/bpl-180074 · Cited by 55 · see citing works
The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment
Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works
“The pathology of AD manifests with degeneration of the neurons, along with loss of synapses in the cortex, the hippocampus, and the subcortical structures [12].”
Background
- Authors
- Vickers, J.
- Affiliations
- University of Tasmania (AU)
- Corresponding author
- Vickers, J
- ORCID
- Vickers, J
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 60
- Issue
- 2
- Pages
- 139-165
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2111417422
- Cited by
- 254
- References
- 329
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 12 · 2013: 6 · 2012: 7
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurodegeneration, amyloid plaques, neurofibrillary tangles, dystrophic neurites, axonal injury, cytoskeletal alterations, dementia, neuroprotection, preclinical Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Humans, Nerve Degeneration
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