McGeer, Patrick L.

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 2,990

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies

McGeer, P. L., Schulzer, M., & McGeer, E. G. (1996) · Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,367

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 836

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsComplement system in diseases

Cited by 817

Glial reactions in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 701

Microglia in degenerative neurological disease

McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 596

NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies

McGeer, P. L., & McGeer, E. G. (2007) · Neurobiology of Aging

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 498

Inflammatory processes in amyotrophic lateral sclerosis

McGeer, P. L., & McGeer, E. G. (2002) · Muscle & Nerve

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 470

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

McGeer, P. L., & McGeer, E. G. (2013) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 467

Brain microglia constitutively express β-2 integrins

Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 430

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003) · Annals of Neurology

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 400

Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters

Complement system in diseasesAlzheimer's disease research and treatments

Cited by 383

Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

Itagaki, S., McGeer, P. L., & Akiyama, H. (1988) · Neuroscience Letters

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 271

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 227

Inflammation, Antiinflammatory Agents, and Alzheimer’s Disease: The Last 22 Years

McGeer, P. L., Rogers, J., & McGeer, E. G. (2016) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 215

Distribution of clusterin in Alzheimer brain tissue

McGeer, P. L., Kawamata, T., & Walker, D. G. (1992) · Brain Research

Alzheimer's disease research and treatmentsClusterin in disease pathology

Cited by 212

Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide

Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P. L., & Kanba, S. (2007) · Experimental Neurology

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 198

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

Tooyama, I., Kimura, H., Akiyama, H., & McGeer, P. L. (1990) · Brain Research

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 180

Inflammation, the complement system and the diseases of aging

McGeer, E. G., Klegeris, A., & McGeer, P. L. (2005) · Neurobiology of Aging

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 170

Complement gene expression in human brain: comparison between normal and Alzheimer disease cases

Walker, D. G., & McGeer, P. L. (1992) · Molecular Brain Research

Complement system in diseasesAlzheimer's disease research and treatments

Cited by 167

Distribution of choline acetyltransferase-containing neurons of the hypothalamus

Tago, H., McGeer, P. L., Bruce, G., & Hersh, L. B. (1987) · Brain Research

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 142

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 137

Inflammation in transgenic mouse models of neurodegenerative disorders

Schwab, C., Klegeris, A., & McGeer, P. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 97

The Role of Anti-Inflammatory Agents in Parkinson???s Disease

McGeer, E. G., & McGeer, P. L. (2007) · CNS Drugs

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 95