Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

Straub, Rainer H.; Herfarth, Hans; Falk, Werner; Andus, Tilo; Schölmerich, Jürgen

doi:10.1016/s0165-5728(02)00047-4

Cited by 115Stress Responses and CortisolInflammatory Bowel DiseaseAdrenal Hormones and Disorders

Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

Straub, Rainer H., Herfarth, Hans, Falk, Werner, Andus, Tilo, Schölmerich, Jürgen·2002·Journal of Neuroimmunology

DOI 10.1016/s0165-5728(02)00047-4

Open this paper in CoChat — free account

Abstract

In inflammatory diseases such as Crohn's disease (CD) and ulcerative colitis (UC), one would expect that TNF or IL-6 stimulates the hypothalamus, which activates the hypothalamus-autonomic nervous system (HANS) axis and the hypothalamic-pituitary-adrenal (HPA) axis in a parallel fashion. The study was initiated in order to investigate the parallelism of the HANS and HPA axes. We measured a typical marker of the HANS axis (neuropeptide Y, NPY) and of the HPA axis (serum cortisol). Plasma NPY was positively correlated with serum cortisol in control subjects (R(Rank)=0.259, p=0.026), which is a sign for the parallel activation of the two axes in healthy subjects. However, serum cortisol was not correlated with plasma NPY in CD or UC patients. In the active CD or UC, inclusion of patients with and without prior prednisolone therapy revealed a negative correlation between the serum cortisol and plasma NPY (CD: R(Rank)=-0.285, p<0.05; UC: R(Rank)=-0.510, p<0.01). This study demonstrates that the two stress axes seem to act in a parallel fashion in control subjects but are uncoupled in IBD patients. Uncoupling of these two axes may be partly due to prior corticosteroid therapy, whereas inverse coupling is a result of simultaneous corticosteroid therapy. It is discussed how the uncoupling of the two anti-inflammatory stress axes can appear.

Integrity signals

Registry

Crossref · 10.1016/s0165-5728(02)00047-4

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

There is a dissociation between high activity of the sympathetic nervous system and relatively normal activity of the HPA axis in chronic inflammatory diseases.
“There seems to be a dissociation between high activity of the SNS and relatively normal activity of the HPA axis in CIDs [114,115].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [114]

The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System
Elenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252 · see citing works
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519 · see citing works
Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial.
Rachmilewitz, D. (1989) · BMJ · doi:10.1136/bmj.298.6666.82 · Cited by 1,038 · see citing works
Admission criteria for immunogerontological studies in man: The senieur protocol
Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90152-0 · Cited by 754 · cited 1× · see citing works
“The questionnaire was adapted from the SENIEUR protocol for immunogerontological studies (Ligthart et al., 1984).”
Method
Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.
Sternberg, E. M., Hill, J. M., Chrousos, G. P., Kamilaris, T., Listwak, S. J., Gold, P. W., & Wilder, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2374 · Cited by 723 · see citing works
Intraadrenal interactions in the regulation of adrenocortical steroidogenesis.
Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., & Vinson, G. P. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0326 · Cited by 600 · cited 1× · see citing works
“Furthermore, there are positive stimulatory links between the catecholamine secreting chromaffin cells and the steroid producing adrenocortical cells (Ehrhart-Bornstein et al., 1998), which indicate that the HPA axis and HANS axis ought to act in a parallel fashion.”
Background
Recombinant interleukin-6 activates the hypothalamic-pituitary-adrenal axis in humans.
Mastorakos, G., Chrousos, G. P., & Weber, J. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263159 · Cited by 591 · see citing works
Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging
Poynter, M. E., & Daynes, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32833 · Cited by 551 · see citing works
Hypothalamic–pituitary–adrenal axis perturbations in patients with fibromyalgia
Crofford, L. J., Pillemer, S. R., Kalogeras, K. T., Cash, J. M., Michelson, D., Kling, M. A., Sternberg, E. M., Gold, P. W., Chrousos, G. P., & Wilder, R. L. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780371105 · Cited by 508 · see citing works
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.
MURCH, S. H., Lamkin, V. A., Savage, M. O., Walker‐Smith, J. A., & MacDonald, T. T. (1991) · Gut · doi:10.1136/gut.32.8.913 · Cited by 482 · see citing works
Stress-Induced Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and Pituitary-Adrenocortical and Sympathoadrenal Activity: In Vivo Microdialysis Studies
Pacák, K., Palkovits, M., Kopin, I. J., & Goldstein, D. S. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1004 · Cited by 395 · see citing works
Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.
Renz, H., Gong, J., Schmidt, A. S., Nain, M., & Gemsa, D. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2388 · Cited by 394 · see citing works
Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence
Straub, R. H., Konecná, L., Hrach, S., Rothe, G., Kreutz, M. P., Schölmerich, J., Falk, W., & Lang, B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4876 · Cited by 352 · see citing works
Self-citation
An index of inflammatory activity in patients with Crohn's disease.
van Hees, P. A., van Elteren, P., van Lier, H. J. J., & van Tongeren, J. H. (1980) · Gut · doi:10.1136/gut.21.4.279 · Cited by 330 · see citing works
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
Groß, V., Andus, T., Caesar, I., Roth, M., & Schölmerich, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90098-j · Cited by 293 · see citing works
Self-citation
Differential regulatory effects of adenosine on cytokine release by activated human monocytes.
Bouma, M. G., Stad, R. K., van den Wildenberg, F. A. J. M., & Buurman, W. A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.9.4159 · Cited by 284 · see citing works
Tumor Necrosis Factor as a Potent Inhibitor of Adrenocorticotropin-Induced Cortisol Production and Steroidogenic P450 Enzyme Gene Expression in Cultured Human Fetal Adrenal Cells*
JÄÄTTELÄ, M., ILVESMÄKI, V., VOUTILAINEN, R., STENMAN, U.-H., & SAKSELA, E. (1991) · Endocrinology · doi:10.1210/endo-128-1-623 · Cited by 243 · see citing works
Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: Stimulation of feeding and the release of corticosterone, vasopressin and glucose
LEIBOWITZ, S. F., Sladek, C. D., Spencer, L., & Tempel, D. L. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90025-1 · Cited by 215 · see citing works
Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome
Adler, G. K., Kinsley, B. T., Hurwitz, S., Mossey, C. J., & Goldenberg, D. L. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00074-1 · Cited by 200 · see citing works
IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans.
Jablons, D. M., Mulé, J. J., McIntosh, J. K., Sehgal, P. B., May, L. T., Huang, C. M., Rosenberg, S. A., & Lotze, M. T. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.5.1542 · Cited by 200 · see citing works
Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis
Ehrhart‐Bornstein, M. (1998) · Endocrine Reviews · doi:10.1210/er.19.2.101 · Cited by 162 · see citing works
Dialogue between the CNS and the immune system in lymphoid organs
Straub, R. H., Westermann, J., Schölmerich, J., & Falk, W. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01297-3 · Cited by 159 · see citing works
Self-citation
Increases in plasma neuropeptide Y concentrations during sympathetic activation in man
Morris, M. J., Russell, A. E., Kapoor, V., Cain, M. D., Elliott, J. M., West, M. J., Wing, L. M. H., & Chalmers, J. P. (1986) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(86)90089-5 · Cited by 159 · see citing works
Glucocorticoid Physiology, Pharmacology and Stress
Munck, A. U., & Guyre, P. M. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5101-6_6 · Cited by 158 · see citing works
Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man.
Späth-Schwalbe, E., Born, J., Schrezenmeier, H., Bornstein, S. R., Stromeyer, P., Drechsler, S., Fehm, H. L., & Porzsolt, F. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962296 · Cited by 145 · cited 3× · see citing works
“Beside the IL-6-induced decrease of the hypothalamic–pituitary responsiveness (Mastorakos et al., 1993; Späth-Schwalbe et al., 1994), other cytokines may influence the adrenal steroidogenesis on the local adrenal level as well.”
Background
The effects of interleukin-1β on the activity of adrenal, splenic and renal sympathetic nerves in the rat
Niijima, A., Hori, T., Aou, S., & Oomura, Y. (1991) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(91)90042-2 · Cited by 141 · see citing works
The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis.
Xiong, Y., & Hales, D. B. (1993) · Endocrinology · doi:10.1210/endo.132.6.8504748 · Cited by 139 · see citing works
The release of tumor necrosis factor from endotoxin-stimulated rat Kupffer cells is regulated by prostaglandin E2 and dexamethasone
Karck, U., Peters, T., & Decker, K. (1988) · Journal of Hepatology · doi:10.1016/s0168-8278(88)80008-4 · Cited by 136 · see citing works
Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production
Danenberg, H. D., Alpert, G., Lustig, S., & Ben‐Nathan, D. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.10.2275 · Cited by 129 · see citing works
Increased urine catecholamines and cortisol in women with irritable bowel syndrome.
Heitkemper, M. M., Jarrett, M. E., Cain, K. C., Shaver, J. L. F., Bond, E. F., Woods, N. F., & Walker, E. F. (1996) · PubMed · Cited by 127 · see citing works
Inhibition of human monocyte TNF production by adenosine receptor agonists
Vraux, V. L., Chen, Y. L., Masson, I., Sousa, M. D., Giroud, J., Florentin, I., & Chauvelot‐Moachon, L. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90632-d · Cited by 112 · see citing works
Altered autonomic function in patients with arthritis or with chronic myofascial pain
Perry, F., Heller, P. H., Kamiya, J., & Levine, J. D. (1989) · Pain · doi:10.1016/0304-3959(89)90177-2 · Cited by 102 · see citing works
Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure
Hulting, J., Sollevi, A., Ullman, B., Franco‐Cereceda, A., & Lundberg, J. M. (1990) · Cardiovascular Research · doi:10.1093/cvr/24.2.102 · Cited by 102 · see citing works
Tumor Necrosis Factor-α Inhibits Leydig Cell Steroidogenesis through a Decrease in Steroidogenic Acute Regulatory Protein Expression1
Mauduit, C., Gasnier, F., Rey, C., Chauvin, M., Stocco, D. M., Louisot, P., & Benahmed, M. (1998) · Endocrinology · doi:10.1210/endo.139.6.6077 · Cited by 99 · see citing works
Regulation of Expression of Dopamine β‐Hydroxylase in PC12 Cells by Glucocorticoids and Cyclic AMP Analogues
McMahon, A., & Sabban, E. L. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10092.x · Cited by 97 · see citing works
Interleukin-1 Inhibits Cholesterol Side-Chain Cleavage Cytochrome P450 Expression in Primary Cultures of Leydig Cells*
Lin, T., WANG, D., Nagpal, M. L., CALKINS, J. H., CHANG, W., & Chi, R. (1991) · Endocrinology · doi:10.1210/endo-129-3-1305 · Cited by 95 · see citing works
Catecholamine-induced suppression of interleukin-1 production.
Wc, K., Fann, A. V., Ma, D., & Lachman, L. B. (1986) · PubMed · Cited by 80 · see citing works
Glucocorticoid regulation of beta-adrenergic receptors in 3T3-L1 preadipocytes.
Nakada, M. T., Stadel, J. M., Poksay, K. S., & Crooke, S. T. (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10446-x · Cited by 78 · cited 3× · see citing works
“Since cortisol and the neurotransmitters of the sympathetic nervous system cooperate with respect to their effects on cells (Cotecchia and De Blasi, 1984; Nakada et al., 1987; Fernandes et al., 1988; McMahon and Sabban, 1992), the presence of both factors in the vicinity of nerve terminals may be necessary for an opti…”
Background
Nuclear factor-κB activity and intestinal inflammation in dextran sulphate sodium (DSS)-induced colitis in mice is suppressed by gliotoxin
Herfarth, H. H., Brand, K., Rath, H. C., Rogler, G., Schölmerich, J., & Falk, W. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01184.x · Cited by 74 · see citing works
Self-citation
Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis
Straub, R. H., Antoniou, E., Zeuner, M., Groß, V., Schölmerich, J., & Andus, T. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00150-1 · Cited by 67 · see citing works
Self-citation
Hydrocortisone Regulation of Interleukin-6 Protein Production by a Purified Population of Human Peripheral Blood Monocytes
Breuninger, L. M., Dempsey, W. L., Uhl, J., & Murasko, D. M. (1993) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1993.1171 · Cited by 61 · see citing works
Tissue-specific increase in norepinephrine turnover by central interleukin-1, but not by interleukin-6, in rats
Terao, A., Oikawa, M., & Saito, M. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.2.r400 · Cited by 58 · see citing works
Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog
Inoue, T., Inui, A., Okita, M., Sakatani, N., Oya, M., Morioka, H., Mizuno, N., Oimoni, M., & Baba, S. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90556-0 · Cited by 55 · see citing works
Peripheral Catecholamines Are Involved in the Neuroendocrine and Immune Effects of LPS
Delrue-Perollet, C., Li, K., Vitiello, S., & Neveu, P. J. (1995) · Brain Behavior and Immunity · doi:10.1006/brbi.1995.1014 · Cited by 48 · see citing works
The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis
Xiong, Y. (1993) · Endocrinology · doi:10.1210/en.132.6.2438 · Cited by 48 · see citing works
Direct effects of interleukin-6 on human adrenal cells
Päth, G., Bornstein, S. R., Späth-schwaibe, E., & Scherbaum, W. A. (1996) · Endocrine Research · doi:10.1080/07435809609043788 · Cited by 46 · see citing works
The sympathetic nervous system tonically inhibits peripheral interleukin-1β and interleukin-6 induction by central lipopolysaccharide
Luigi, A. D., Terreni, L., Sironi, M., & Simoni, M. G. D. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00381-3 · Cited by 43 · see citing works
Altered function of the hypothalamic stress axes in patients with moderately active systemic lupus erythematosus. I. The hypothalamus-autonomic nervous system axis.
Glück, T., Oertel, M., Reber, T., Zietz, B., Schölmerich, J., & Straub, R. H. (2000) · PubMed · Cited by 41 · see citing works
Self-citation
Central interferon-alpha inhibits natural killer cytotoxicity through sympathetic innervation
Take, S., Mori, T., Katafuchi, T., & Hori, T. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.2.r453 · Cited by 38 · see citing works
Long-term stimulatory effect of neuropeptide-Y on the growth and steroidogenic capacity of rat adrenal zona glomerulosa
Rebuffat, P., Malendowicz, L. K., Belloni, A. S., Mazzocchi, G., & Nussdorfer, G. G. (1988) · Neuropeptides · doi:10.1016/0143-4179(88)90082-0 · Cited by 34 · see citing works
Glucocorticoids increase β-adrenoceptors on human intact lymphocytes
Cotecchia, S., & Blasi, A. D. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90528-9 · Cited by 31 · see citing works
The Effect of Hydrocortisone on the Production of γ-Interferon and Other Lymphokines by Human Peripheral Blood Mononuclear Cells
Cesario, T. C., Slater, L. M., Poo, W. J., Spindler, B., Walter, B. N., Gorse, G. J., & Carandang, G. (1986) · Journal of Interferon Research · doi:10.1089/jir.1986.6.337 · Cited by 28 · see citing works
Tumor Necrosis Factor- Inhibits Leydig Cell Steroidogenesis through a Decrease in Steroidogenic Acute Regulatory Protein Expression
Mauduit, C. (1998) · Endocrinology · doi:10.1210/en.139.6.2863 · Cited by 28 · see citing works
β-Adrenoceptor desensitization in guinea-pig isolated trachea
Fernandes, L. B., Knight, D. A., Rigby, P. J., Spina, D., Paterson, J. W., & Goldie, R. G. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90376-7 · Cited by 23 · see citing works
Acute sympathetic hyperfunction in overlapping syndromes of systemic lupus erythematosus and polymyositis.
Nakajima, A., Sendo, W., Tsutsumino, M., Koseki, Y., Ichikawa, N., Akama, H., Taniguchi, A., Terai, C., Hara, M., & Kashiwazaki, S. (1998) · PubMed · Cited by 16 · see citing works
Effects of Adrenalectopmy on the Stress-Induced Changes in Ovarian Sympathetic Tone in the Rat
Galvez, A. S., Paredes, A., Fiedler, J. L., Venegas, M., & Lara, H. E. (1999) · Endocrine · doi:10.1385/endo:10:2:131 · Cited by 14 · see citing works

Flagged first, then by citations

3 of the 59 references couldn’t be matched to a known paper.

Sorted by citations

Brain–Gut Interactions in Inflammatory Bowel Disease
Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667 · see citing works
Psychological stress in IBD: new insights into pathogenic and therapeutic implications
Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622 · see citing works
Neuropeptide, Y, peptide YY and pancreatic polypeptide in the gut-brain axis
Holzer, P., Reichmann, F., & Farzi, A. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.08.005 · Cited by 501 · see citing works
Neuropeptides and the Microbiota-Gut-Brain Axis
Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451 · see citing works
Autonomic Nervous System and Immune System Interactions
Kenney, M., & Ganta, C. K. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130051 · Cited by 383 · see citing works
A comparison of mindfulness-based stress reduction and an active control in modulation of neurogenic inflammation
Rosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.013 · Cited by 307 · see citing works
The role of the sympathetic nervous system in intestinal inflammation
Straub, R. H., Wiest, R., Strauch, U. G., Härle, P., & Schölmerich, J. (2006) · Gut · doi:10.1136/gut.2006.091322 · Cited by 237 · see citing works
Self-citation
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 234 · see citing works
Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects
Daniela, M., Luca, C. M., Onu, I., Paula, M., Iordan, D. A., & Buculei, I. (2022) · Antioxidants · doi:10.3390/antiox11020350 · Cited by 244 · see citing works
Adrenal Insufficiency and Colonic Inflammation after a Novel Chronic Psycho-Social Stress Paradigm in Mice: Implications and Mechanisms
Reber, S. O., Birkeneder, L., Veenema, A. H., Obermeier, F., Falk, W., Straub, R. H., & Neumann, I. (2006) · Endocrinology · doi:10.1210/en.2006-0983 · Cited by 212 · see citing works
Self-citation
Stress and the Brain-Gut Axis in Functional and Chronic-Inflammatory Gastrointestinal Diseases: A Transdisciplinary Challenge
Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200 · see citing works
Neural immune pathways and their connection to inflammatory diseases.
Eskandari, F., Webster, J. I., & Sternberg, E. M. (2003) · Arthritis Research · doi:10.1186/ar1002 · Cited by 201 · see citing works
Altered neuro-endocrine–immune pathways in the irritable bowel syndrome: the top-down and the bottom-up model
Stasi, C., Rosselli, M., Bellini, M., Laffi, G., & Milani, S. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0627-7 · Cited by 148 · see citing works
The homeostatic role of neuropeptide <scp>Y</scp> in immune function and its impact on mood and behaviour
Farzi, A., Reichmann, F., & Holzer, P. (2015) · Acta Physiologica · doi:10.1111/apha.12445 · Cited by 145 · see citing works
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies
Darmani, N. A., Izzo, A. A., Degenhardt, B. F., Valenti, M., Scaglione, G., Capasso, R., Sorrentini, I., & Marzo, V. D. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.01.001 · Cited by 144 · see citing works
The Effect of Acute Psychologic Stress on Systemic and Rectal Mucosal Measures of Inflammation in Ulcerative Colitis
Mawdsley, J. E., Macey, M. G., Feakins, R. M., Langmead, L., & Rampton, D. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.017 · Cited by 143 · see citing works
Chronic Intermittent Psychosocial Stress (Social Defeat/Overcrowding) in Mice Increases the Severity of an Acute DSS-Induced Colitis and Impairs Regeneration
Reber, S. O., Obermeier, F., Straub, R. H., Falk, W., & Neumann, I. D. (2006) · Endocrinology · doi:10.1210/en.2006-0347 · Cited by 137 · see citing works
Self-citation
Relevance of Neuropeptide Y for the neuroimmune crosstalk
Bedoui, S., Kawamura, N., Straub, R. H., Pabst, R., Yamamura, T., & von Hörsten, S. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00424-1 · Cited by 134 · see citing works
Self-citation
Brain-immune interactions and disease susceptibility
Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 132 · see citing works
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“[114,115].”
Self-citation
The Role of Psychological Stress in Inflammatory Bowel Disease
Mawdsley, J. E. D., & Rampton, D. S. (2006) · NeuroImmunoModulation · doi:10.1159/000104861 · Cited by 116 · see citing works
Stress and animal models of inflammatory bowel disease—An update on the role of the hypothalamo–pituitary–adrenal axis
Reber, S. O. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.014 · Cited by 115 · see citing works
Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems
Härle, P., Straub, R. H., Wiest, R., Mayer, A., Schölmerich, J., Atzeni, F., Carrabba, M., Cutolo, M., & Sarzi-Puttini, P. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.038059 · Cited by 114 · see citing works
Self-citation
The Role of the Mesentery in Crohnʼs Disease
Li, Y., Zhu, W., Zuo, L., & Shen, B. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000791 · Cited by 111 · see citing works
The Endocannabinoid System and Physical Exercise
Matei, D., Trofin, D., Iordan, D. A., Onu, I., Condurache, I., Ionițe, C., & Buculei, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031989 · Cited by 118 · see citing works
The Brain-Gut Axis in Health and Disease
Omran, Y. A., & Aziz, Q. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0897-4_6 · Cited by 106 · see citing works
Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y
Painsipp, E., Herzog, H., Sperk, G., & Holzer, P. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01326.x · Cited by 93 · see citing works
Brain and Gut Interactions in Irritable Bowel Syndrome: New Paradigms and New Understandings
Coss‐Adame, E., & Rao, S. S. C. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0379-z · Cited by 89 · see citing works
Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases—The 10-year update
Straub, R. H., Bijlsma, J. W. J., Masi, A. T., & Cutolo, M. (2013) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2013.04.008 · Cited by 86 · see citing works
Self-citation
Disruption of the blood–brain barrier during TNBS colitis
Natah, S. S., Mouihate, A., Pittman, Q. J., & Sharkey, K. A. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00654.x · Cited by 79 · see citing works
Neuroendocrine mechanisms of immune dysregulation: applications to allergy and asthma
Marshall, G. D. (2004) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61482-2 · Cited by 78 · see citing works
Review article: the role of the autonomic nervous system in the pathogenesis and therapy of IBD
Mogilevski, T., Burgell, R., Aziz, Q., & Gibson, P. R. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15433 · Cited by 75 · see citing works
Old Friends, immunoregulation, and stress resilience
Langgartner, D., Lowry, C. A., & Reber, S. O. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2228-7 · Cited by 73 · see citing works
Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF
Haas, S., & Straub, R. H. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3852 · Cited by 71 · see citing works
Self-citation
Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases
Straub, R. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.08.002 · Cited by 69 · see citing works
Self-citation
Chronic Subordinate Colony Housing Paradigm: A Mouse Model to Characterize the Consequences of Insufficient Glucocorticoid Signaling
Langgartner, D., Füchsl, A. M., Uschold‐Schmidt, N., Slattery, D. A., & Reber, S. O. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00018 · Cited by 70 · see citing works
Corticosteroid resistance in a subpopulation of multiple sclerosis patients as measured by ex vivo dexamethasone inhibition of LPS induced IL-6 production
DeRijk, R. H., Eskandari, F., & Sternberg, E. M. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.02.009 · Cited by 60 · see citing works
Autonomic Nervous System and Immune System Interactions
Kenney, M., & Ganta, C. K. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00574.x · Cited by 56 · see citing works
Role of the Brain-Gut Axis in the Pathophysiology of Crohn’s Disease
Stasi, C., & Orlandelli, E. (2008) · Digestive Diseases · doi:10.1159/000116774 · Cited by 54 · see citing works
Increased aggregation response of platelets in patients with inflammatory bowel disease
Andoh, A., Yoshida, T., Yagi, Y., Bamba, S., Hata, K., Tsujikawa, T., Kitoh, K., Sasaki, M., & Fujiyama, Y. (2006) · Journal of Gastroenterology · doi:10.1007/s00535-005-1721-x · Cited by 50 · see citing works
The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD)
El‐Salhy, M., & Hausken, T. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.09.005 · Cited by 54 · see citing works
During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH
Kizildere, S., Glück, T., Zietz, B., Schölmerich, J., & Straub, R. H. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480045 · Cited by 41 · see citing works
Self-citation
Unraveling the fatigue puzzle: insights into the pathogenesis and management of IBD-related fatigue including the role of the gut-brain axis
Truyens, M., Lernout, H., Vos, M. D., Laukens, D., & Lobatón, T. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1424926 · Cited by 39 · see citing works
Uncoupling of sympathetic nervous system and hypothalamic‐pituitary‐adrenal axis in cirrhosis
Wiest, R., Moleda, L., Zietz, B., Hellerbrand, C., Schölmerich, J., & Straub, R. H. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05456.x · Cited by 36 · see citing works
Self-citation
Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study
Stasi, C., Bellini, M., Gambaccini, D., Duranti, E., de Bortoli, N., Fani, B., Albano, E., Russo, S., Sudano, I., Laffi, G., et al. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16155 · Cited by 36 · see citing works
The link between negative affect, vagal tone, and visceral sensitivity in quiescent C rohn's disease
Rubio, A., Sonia Pellissier, A., Picot, A., Dantzer, C., & Bonaz, B. L. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12373 · Cited by 34 · see citing works
Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis
Ciesielczyk, K., Furgała, A., Dobrek, Ł., Juszczak, K., & Thor, P. J. (2017) · Archives of Medical Science · doi:10.5114/aoms.2015.55147 · Cited by 32 · see citing works
Heart rate variability and inflammatory bowel disease in humans
Kim, K.-N., Yao, Y., & Ju, S.-Y. (2020) · Medicine · doi:10.1097/md.0000000000023430 · Cited by 31 · see citing works
Autonomic Dysfunction in Rheumatic Diseases
Straub, R. H., Baerwald, C., Wahle, M., & Jänig, W. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.09.002 · Cited by 30 · see citing works
Self-citation
Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide
Pang, X. H., Li, T. K., Xie, Q., He, F. Q., Cui, D. J., Chen, Y. Q., Huang, X. L., & Gan, H. T. (2010) · International Journal of Colorectal Disease · doi:10.1007/s00384-010-0964-z · Cited by 25 · see citing works
Psychoneuroimmunologic factors in inflammatory bowel disease
Mackner, L. M., Clough-Paabo, E., PAJER, K. A., Lourie, A., & Crandall, W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21430 · Cited by 25 · see citing works
Effects of intestinal inflammation on specific subgroups of guinea-pig celiac ganglion neurons
Dong, X.-X., Thacker, M., Pontell, L. J., Furness, J. B., & Nurgali, K. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.045 · Cited by 24 · see citing works
Toward a better understanding of the central consequences of intestinal inflammation
Nyuyki, K. D., & Pittman, Q. J. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12935 · Cited by 23 · see citing works
Activated sympathetic nerve post stroke downregulates Toll-like receptor 5 and disrupts the gut mucosal barrier
Wang, H., Li, J., Wu, G., Lin, X., Chen, J., Liang, J., Zhang, J., Luo, X., Mao, H., Xie, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101754 · Cited by 22 · see citing works
Disturbed in vitro adrenergic modulation of cytokine production in inflammatory bowel diseases in remission
Lucas, A., Cobelens, P. M., Kavelaars, A., Heijnen, C. J., Holtmann, G., Haag, S., Gerken, G., Langhorst, J., Dobos, G., Schedlowski, M., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.09.011 · Cited by 22 · see citing works
Functional disruption of cortical cingulate activity attenuates visceral hypersensitivity and anxiety induced by acute experimental colitis
Brenner, L., Zerlin, L., & Tan, L. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-81256-x · Cited by 21 · see citing works
Cardiovascular and pupillary autonomic nervous dysfunction in patients with rheumatoid arthritis - a cross-sectional and longitudinal study.
Schwemmer, S., Beer, P., Schölmerich, J., Fleck, M., & Straub, R. H. (2006) · PubMed · Cited by 21 · see citing works
Self-citation
Depression has a Strong Relationship to Alterations in the Immune, Endocrine and Neural System
Hestad, K. A., Aukrust, P., Tønseth, S., & Reitan, S. K. (2009) · Current Psychiatry Reviews · doi:10.2174/157340009789542105 · Cited by 20 · see citing works
Nonpeptide Corticotropin-Releasing Hormone Receptor Type 1 Antagonists and Their Applications in Psychosomatic Disorders
Contoreggi, C. S., Rice, K. C., & Chrousos, G. P. (2004) · Neuroendocrinology · doi:10.1159/000081785 · Cited by 20 · see citing works
Predictive and potentially predictive factors in early arthritis: a multidisciplinary approach
Härle, P. (2005) · British journal of rheumatology · doi:10.1093/rheumatology/keh530 · Cited by 19 · see citing works
A method for describing and evaluating naturopathic whole practice.
Herman, P. M., Sherman, K. J., Erro, J. H., Cherkin, D. C., Milliman, B., & Adams, L. A. (2006) · PubMed · Cited by 16 · see citing works
Impact of comorbid psychiatric disorders on healthcare utilization in patients with inflammatory bowel disease: A nationally representative cohort study
Hill, E., Nguyen, N. H., Qian, A. S., Patel, S., Chen, P. L., Tse, C.-S., & Singh, S. (2022) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07505-9 · Cited by 15 · see citing works
Emerging Concepts for the Pathogenesis of Chronic Disabling Inflammatory Diseases: Neuroendocrine-immune Interactions and Evolutionary Biology
STRAUB, R. H., DEL REY, A., & BESEDOVSKY, H. O. (2007) · Psychoneuroimmunology · doi:10.1016/b978-012088576-3/50014-9 · Cited by 14 · see citing works
Self-citation
Systemic disease sequelae in chronic inflammatory diseases and chronic psychological stress: comparison and pathophysiological model
Straub, R. H. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12409 · Cited by 14 · see citing works
Self-citation
Effects of Some Kampo Medicines on Plasma Levels of Neuropeptide Y under Venipuncture Stress
Sato, Y., Katagiri, F., Itoh, H., & Takeyama, M. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1757 · Cited by 14 · see citing works
Regulatory Role of the Pituitary-Adrenal Axis in Experimental Colitis: Effect of Adrenalectomy on the Clinical Course and the TH1/TH2 Immune Profile
Shibolet, O., Alper, R., Ilan, Y., & Weidenfeld, J. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000191610.97842.51 · Cited by 14 · see citing works
Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat
Kang, J. W., Kim, T. W., La, J., Sung, T. S., Kim, H. J., Kwon, Y., Kim, J. Y., & Yang, I. S. (2004) · Journal of Veterinary Science · doi:10.4142/jvs.2004.5.3.189 · Cited by 14 · see citing works
A bio-behavioral study of chronic idiopathic colitis in the rhesus macaque (Macaca mulatta)
Howell, S., White, D., Ingram, S., Jackson, R., Larin, J., Morales, P. R., García, A. P., Hicks, C., Hopper, K., & Wagner, J. (2012) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2012.01.003 · Cited by 13 · see citing works
Disease-specific alterations in central fear network engagement during acquisition and extinction of conditioned interoceptive fear in inflammatory bowel disease
Lanters, L. R., Öhlmann, H., Langhorst, J., Theysohn, N., Engler, H., Icenhour, A., & Elsenbruch, S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02612-7 · Cited by 13 · see citing works
Cardiac and autonomic function in patients with Crohn’s disease during remission
Zawadka‐Kunikowska, M., Słomko, J., Kłopocka, M., Liebert, A., Tafil‐Klawe, M., Klawe, J. J., Newton, J. L., & Zalewski, P. (2018) · Advances in Medical Sciences · doi:10.1016/j.advms.2018.04.009 · Cited by 11 · see citing works
Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health
Öhlmann, H., Lanters, L. R., Theysohn, N., Langhorst, J., Engler, H., Icenhour, A., & Elsenbruch, S. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad080 · Cited by 10 · see citing works
Bottom-up and top-down signaling of IL-6 with and without habituation?
Straub, R. H. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.06.009 · Cited by 10 · see citing works
Self-citation
The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity
Ruiz-Pablos, M., Paiva, B., & Zabaleta, A. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1710571 · Cited by 11 · see citing works
A History of Psycho-Neuro-Endocrine Immune Interactions in Rheumatic Diseases
Straub, R. H., & Cutolo, M. (2024) · NeuroImmunoModulation · doi:10.1159/000540959 · Cited by 11 · see citing works
Self-citation
Identification and comparison of microRNAs in pituitary gland during prenatal and postnatal stages of sheep by deep sequencing
Li, X., Li, C., Ni, W., Wang, D., Hou, X., Liu, Z., Cao, Y., Yao, Y., Zhang, X., & Hu, S. (2018) · Journal of Genetics · doi:10.1007/s12041-018-0991-z · Cited by 7 · see citing works
Stimulation of proinflammatory cytokines by volatile sulfur compounds in endodontically treated teeth
Lechner, J., & von Baehr, V. (2015) · International Journal of General Medicine · doi:10.2147/ijgm.s77693 · Cited by 7 · see citing works
A Study of Dizziness or Vertigo Cases Associated with Inflammatory Bowel Disease (Crohn’s Disease and Ulcerative Colitis) in a Vertigo Outpatient Clinic
Kamogashira, T., Nakada, T., & Kanaya, K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020341 · Cited by 6 · see citing works
Myocardial IL-6 regulation by neurohormones—an in vitro superfusion study
Jeron, A., Kaiser, T., Straub, R. H., Weil, J., Riegger, G. A. J., & Muders, F. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00053-9 · Cited by 6 · see citing works
Self-citation
Stress and the Gastrointestinal System
Bonaz, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-28609-9_7 · Cited by 6 · see citing works
Neuroendocrine-immune aspects of accelerated aging in rheumatoid arthritis
Härle, P., & Straub, R. H. (2005) · Current Rheumatology Reports · doi:10.1007/s11926-005-0027-6 · Cited by 5 · see citing works
Self-citation
Psychological Stress in Chronic Intestinal Diseases
Byun, Y. J., & Eun, C. S. (2014) · Hanyang Medical Reviews · doi:10.7599/hmr.2014.34.2.66 · Cited by 4 · see citing works
Mimicking disruption of brain-immune system-joint communication results in collagen type II-induced arthritis in non-susceptible PVG rats
Wolff, C., Straub, R. H., Hahnel, A., Randolf, A., Wildmann, J., Besedovsky, H. O., & del Rey, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.005 · Cited by 3 · see citing works
Self-citation
Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study
Filip, P., Vojtíšek, Ľ., Jičínská, A. M., Valenta, Z., Horák, O., Hrunka, M., Mangia, S., Michaeli, S., & Jabandžiev, P. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1491770 · Cited by 4 · see citing works
NPY and Immune Functions: Implications for Health and Disease
Bedoui, S., Pabst, R., & von Hörsten, S. (2004) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-18764-3_14 · Cited by 3 · see citing works
Chapter 27 Modulation of Hormone Axes by Anti-TNF Therapy
Atzeni, F., Sarzi‐Puttini, P., Cutolo, M., & Straub, R. H. (2008) · Technical report · doi:10.1016/s1571-5078(07)00227-9 · Cited by 3 · see citing works
Self-citation
Mon cerveau et mon intestin communiquent, parfois mal !
Bonaz, B. L., & Sonia Pellissier, A. (2013) · Pratique Neurologique - FMC · doi:10.1016/j.praneu.2013.10.004 · Cited by 2 · see citing works
Neuroendocrinology of Inflammatory Disorders
Marketon, J. I. W., & Sternberg, E. M. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00217-7 · Cited by 2 · see citing works
Warum gibt es analoge Krankheitsmechanismen bei chronisch entzündlichen Krankheiten?
Straub, R. H., Besedovsky, H. O., & del Rey, A. (2007) · Wiener klinische Wochenschrift · doi:10.1007/s00508-007-0834-z · Cited by 2 · see citing works
Self-citation
An unusual finding in a patient with iron deficiency anaemia
Leyden, J. E., O’Shea, C., Hegarty, S., & MacMathúna, P. (2005) · Gut · doi:10.1136/gut.2005.067082 · Cited by 1 · see citing works
Factors associated with the development of dynapenia in patients with ulcerative colitis
Равильевна, Б. Г., Livzan, M. A., Сергеевна, Л. Н., Евгеньевна, Р. А., & Бондаренко, А. А. (2025) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2025-1-6-13 · Cited by 1 · see citing works
UHRF1 deficiency exacerbates intestinal inflammation by epigenetic modulation of NPY1R gene methylation
Han, Y., Sun, L., Liu, Y., Zhang, X., Liu, H., Zhang, H., Ren, X., Wang, F. F., Fan, H., Chen, J., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.190894 · Cited by 1 · see citing works
Inflammatory Mediators Affect the Autonomic Nervous System
Straub, R. H., Kees, M. G., Janele, D., Pongratz, G., Schölmerich, J., & Härle, P. (2007) · Neuroimmune biology · doi:10.1016/s1567-7443(07)00215-3 · Cited by 1 · see citing works
Self-citation
„Old Friends“, Immunregulation und Stressresilienz
Langgartner, D., Lowry, C. A., & Reber, S. O. (2020) · Nervenheilkunde · doi:10.1055/a-1037-0710 · Cited by 1 · see citing works
Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study
Wasserbauer, M., Malá, Š., Štechová, K., Hlava, Š., Cernikova, P., Šťovíček, J., Drabek, J., Brož, J., Pichlerová, D., Kučerová, B., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294441 · Cited by 1 · see citing works
Pathogenesis and Neuroendocrine Immunology
Straub, R. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-803321-0.00002-1 · Cited by 1 · see citing works
Self-citation
Gut Microbiota in Brain Development and Disorders of the CNS: Therapeutic Strategies Involving Dietary Modification, Pro- and Prebiotic Intervention, and Fecal Microbiota Transplantation (FMT) Therapy
Tungland, B. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814649-1.00012-0 · Cited by 1 · see citing works
Neuroendocrine Immune Mechanisms of Accelerated Ageing in Patients with Chronic Inflammatory Diseases
Straub, R. H., Schölmerich, J., & Cutolo, M. (2004) · Neuroimmune biology · doi:10.1016/s1567-7443(04)80024-3 · Cited by 1 · see citing works
Self-citation
NPY, NPY receptors and DPPIV in innate immunity and autoimmune disorders
Bedoui, S., & von Hörsten, S. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7427-6_5
Psychological Stress: Something to Worry About?
Mawdsley, J. E. D., & Rampton, D. S. (2006) · Wiley eBooks · doi:10.1002/9780470750827.ch35

Uncoupling between the vagal tone and HPA axis in patients with Crohn's disease or irritable bowel syndrome: Relation to stress and inflammation
Sonia Pellissier, A., Dantzer, C., Mondillon, L., Trocmé, C., Mathieu, N., Faure, P., Canini, F., & Bonaz, B. L. (2013) · Autonomic Neuroscience · doi:10.1016/j.autneu.2013.08.054 · Cited by 1 · see citing works
Assessment of hypothalamic-pituitary-adrenal axis function after corticosteroid therapy in inflammatory bowel disease
Desramé, J., Sabaté, J. M., Agher, R., Bremont, C., Gaudric, M., Couturier, D., & Chaussade, S. (2002) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05786.x · Cited by 26 · see citing works
Hypothalamic-pituitary-adrenal dysregulation and psychological distress in Crohn’s disease: Insights from acute and chronic stress responses
Laoudi, E., Papalouka, D., Kokkotis, G., Gkizis, M., Mantzou, A., Lyrakos, G. N., Markopoulos, P. (., Prapa, P. M., Voulgaris, T. A., Vlachogiannakos, J., et al. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.v16.i3.111523
神经-内分泌-免疫网络与炎症性肠病
袁川评, 王玮, & 柳巨雄 (2010)
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome
Chang, L., Sundaresh, S., Elliott, J. E., Anton, P. A., Baldi, P., Licudine, A., Mayer, M., Vuong, T., Hirano, M., Naliboff, B. D., et al. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01171.x · Cited by 250 · see citing works

Authors: Straub, R. H., Herfarth, H., Falk, W., Andus, T., & Schölmerich, J.
Affiliations: University Hospital Regensburg (DE)
ORCID: Straub, Rainer H.
Herfarth, Hans
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2002-05
Volume: 126
Issue: 1-2
Pages: 116-125
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/s0165-5728(02)00047-4
OpenAlex: W2082901516
Semantic Scholar: d6ff2f63c6820d719fdf42dcd5f9a8dcb63589cb
Cited by: 115
References: 59
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 10 · 2013: 4 · 2012: 6
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, hypothalamic-pituitary-adrenal axis, neuropeptide Y, cortisol, corticosteroid therapy, prednisolone, cytokines, TNF-α, interleukin-6
MeSH terms: Adult, Anti-Inflammatory Agents, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Neuropeptide Y, Pituitary-Adrenal System, Prednisolone, Sex Factors, Sympathetic Nervous System, Tumor Necrosis Factor-alpha, Inflammatory Bowel Diseases, Neuroimmunomodulation, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Uncoupling of the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis in inflammatory bowel disease?

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks