The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field
Abstract
At high and medium magnetic field, the transverse NMR relaxation rate (T-1(2)) of water proteins in blood is determined predominantly by the oxygenation state of haemoglobin. T-1(2) depends quadratically on the field strength and on the proportion of haemoglobin that is deoxygenated. Deoxygenation increases the volume magnetic susceptibility within the erythrocytes and thus creates local field gradients around these cells. From volume susceptibility measurements and the dependence of T-1(2) on the pulse rate in the Carr-Purcell-Meiboom-Gill experiment, we show that the increase in T-1(2) with increasing blood deoxygenation arises from diffusion of water through these field gradients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“What causes the BOLD effect is the varying concentration of deoxygenated hemoglobin relative to the total hemoglobin that is either deoxygenated or oxygenated (123).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [123]
In the citing paper
“As a result, the concentration of deoxygenated hemoglobin decreases in capillary and venous vessels, reducing the paramagnetic susceptibility effect and thus increasing the T2*-weighted signal (123).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [123]
In the citing paper
“Because fMRI signal intensity is sensitive to the amount of oxygen carried by hemoglobin (5-7), this change in blood oxygen content at the site of increased brain activity can be detected with fMRI.”
From A default mode of brain function (2001) · cites this paper as [5]
Citations
Cites
Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient
Stejskal, E. O., & Tanner, J. E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1695690 · Cited by 8,239
Modified Spin-Echo Method for Measuring Nuclear Relaxation Times
Meiboom, S., & Gill, D. (1958) · Review of Scientific Instruments · doi:10.1063/1.1716296 · Cited by 6,001
High Resolution Nuclear Magnetic Resonance Spectroscopy
(1966) · Elsevier eBooks · doi:10.1016/c2013-0-05217-6 · Cited by 1,128
Luz, Z., & Meiboom, S. (1963) · The Journal of Chemical Physics · doi:10.1063/1.1734254 · Cited by 553
Biological Applications of Magnetic Resonance
(1979) · Elsevier eBooks · doi:10.1016/b978-0-126-40750-1.x5001-1 · Cited by 432
Examination of a Case of Suspected McArdle's Syndrome by31P Nuclear Magnetic Resonance
Ross, B. D., Radda, G. K., Gadian, D. G., Rocker, G. M., Esiri, M. M., & Smith, J. F. F. (1981) · New England Journal of Medicine · doi:10.1056/nejm198105283042206 · Cited by 427
Self-citationNuclear relaxation in macromolecules by paramagnetic ions: a novel mechanism
Guéron, M. (1975) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(75)90029-3 · Cited by 327
Water diffusion permeability of erythrocytes using an NMR technique
Conlon, T., & Outhred, R. (1972) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(72)90256-8 · Cited by 272
Nuclear relaxation processes of paramagnetic complexes The slow-motion case
Vega, A. J., & Fiat, D. (1976) · Molecular Physics · doi:10.1080/00268977600100261 · Cited by 218
Nuclear-Magnetic-Resonance Study of Self-Diffusion in a Bounded Medium
Wayne, R. C., & Cotts, R. M. (1966) · Physical Review · doi:10.1103/physrev.151.264 · Cited by 186
Research works printed but not linked: 5
- Radda, 1981, J. Magn. Reson., 42, 488
- Gansse, 1980, Phil. Trans. R. Soc. Lond., B289, 438
- Gueron, 1975, J. Magn. Reson., 19, 58
- Packer, 1973, J. Magn. Reson., 9, 438
- Thulborn, 1981, J. Cereb. Blood Flow Metab., 1, S82
Cited by
Sorted by citations
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
The brain's default mode network
Raichle, M. E. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014030 · Cited by 3,904
Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., & Ugurbil, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5951 · Cited by 3,681
Metadata
- Authors
- Thulborn, K. R., Waterton, J. C., Matthews, P. M., & Radda, G. K.
- Affiliations
- University of Oxford (GB)
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 1982-02
- Volume
- 714
- Issue
- 2
- Pages
- 265-270
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W1980086703
- Cited by
- 1,134
- References
- 22
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 20 · 2023: 30 · 2022: 16 · 2021: 22 · 2020: 25 · 2019: 19 · 2018: 15 · 2017: 22 · 2016: 37 · 2015: 37 · 2014: 34 · 2013: 30 · 2012: 47
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › NMR spectroscopy and applications
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Keywords
- T2 relaxation, water protons, whole blood, hemoglobin oxygenation, volume magnetic susceptibility, erythrocytes, diffusion, high magnetic fields, NMR relaxation
- MeSH terms
- Animals, Body Water, Erythrocytes, Hematocrit, Hemoglobins, Male, Magnetic Resonance Spectroscopy, Oxygen, Protons, Rabbits, Rats, Inbred Strains, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
