Modulation of glucocorticoid receptor activity by cyclic nucleotides and its implications on the regulation of human skin fibroblast growth and protein synthesis

Oikarinen, Jouko; Hämäläinen, Leena; Oikarinen, Aarne

doi:10.1016/0304-4165(84)90290-3

Cited by 62Estrogen and related hormone effectsReceptor Mechanisms and SignalingPhosphodiesterase function and regulation

Modulation of glucocorticoid receptor activity by cyclic nucleotides and its implications on the regulation of human skin fibroblast growth and protein synthesis

Oikarinen, Jouko, Hämäläinen, Leena, Oikarinen, Aarne·1984·Biochimica et Biophysica Acta (BBA) - General Subjects

DOI 10.1016/0304-4165(84)90290-3

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Abstract

The modulation of glucocorticoid receptor activity by cyclic nucleotides was studied in cultured human skin fibroblasts. The receptors appeared to be activated in the presence of dibutyryl-cAMP and inactivated by dibutyryl-cGMP. Significantly, the cGMP content of the fibroblasts increased during cell growth, with a concomitant decrease in the glucocorticoid receptor activity, while when the cells reached early confluency the decrease in cGMP content was accompanied by an increase in cAMP and increased activity of the glucocorticoid receptors. In addition, cortisol induced (2'-5')oligoadenylate synthetase in these cells and raised the cellular (2'-5')oligoadenylate concentrations. This resulted in a decrease in both DNA and protein synthesis activity in the cells, a response which correlated with the (2'-5')oligoadenylate concentration. The combination of cortisol and dibutyryl-cAMP had a synergetic stimulatory effect on the (2'-5')oligoadenylate concentration and a synergetic inhibitory effect on protein synthesis. In conclusion, it is demonstrated here that cyclic nucleotides can modulate glucocorticoid receptor activity in cultured human skin fibroblasts, and thus these compounds may indirectly affect cellular metabolism by regulating the cellular responses to glucocorticoids.

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Release of cortisol is typically coupled to release of norepinephrine, which leads to stronger signalling through the beta adrenoceptor.
“Release of cortisol is typically coupled to release of norepinephrine, which leads to stronger signalling through the b adrenoceptor; several studies have shown cooperation of cortisol and norepinephrine at a molecular level.”
From Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems (2006) · cites this paper as [22]

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724 · see citing works
An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates
Pelham, H. R. B., & Jackson, R. J. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10656.x · Cited by 3,926 · see citing works
Biochemistry of Interferons and Their Actions
Lengyel, P. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.001343 · Cited by 866 · see citing works
Animal Cell Cycle
Pardee, A. B., Dubrow, R., Hamlin, J. L., & Kletzien, R. F. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.003435 · Cited by 712 · see citing works
Role of Cyclic Nucleotides in Growth Control
Pastan, I. H., Johnson, G. S., & Anderson, W. B. (1975) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.44.070175.002423 · Cited by 691 · see citing works
Radioimmunoassay for Cyclic Nucleotides
Steiner, A. L., Pagliara, A. S., Chase, L. R., & KIPNIS, D. M. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45622-6 · Cited by 572 · see citing works
A simple direct assay for cyclic amp in plasma and other biological samples using an improved competitive protein binding technique
Tovey, K. C., Oldham, K. G., & Whelan, J. A. M. (1974) · Clinica Chimica Acta · doi:10.1016/0009-8981(74)90133-8 · Cited by 564 · see citing works
Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts
Clemens, M. J., & Williams, B. (1978) · Cell · doi:10.1016/0092-8674(78)90329-x · Cited by 440 · see citing works
Control of collagen production by human diploid lung fibroblasts.
Breul, S. D., Bradley, K. H., Hance, A. J., Schafer, M. P., Berg, R. A., & Crystal, R. G. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70778-9 · Cited by 160 · see citing works
Anti‐mitogenic Function of Interferon‐Induced (2′‐5′)Oligo(adenylate) and Growth‐Related Variations in Enzymes that Synthesize and Degrade This Oligonucleotide
Kimchi, A., Shure, H., & Revel, M. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb06163.x · Cited by 123 · see citing works
Glucocorticoid receptor activation and inactivation in cultured human lymphocytes.
Wheeler, R. H., Leach, K. L., Forest, A. C. L., O’Toole, T. E., Wagner, R., & Pratt, W. B. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70155-0 · Cited by 83 · see citing works
Double-stranded RNA causes synthesis of 2‘,5‘-oligo(A) and degradation of messenger RNA in interferon-treated cells.
Nilsen, T. W., Maroney, P. A., & Baglioni, C. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43350-9 · Cited by 66 · see citing works
Dexamethasone decreases the amounts of type I procollagen mRNAs in vivo and in fibroblast cell cultures.
Sterling, K. M., Harris, M. J., Mitchell, J., DiPetrillo, T. A., Delaney, G. L., & Cutroneo, K. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32227-0 · Cited by 63 · see citing works
Glucocorticoid-mediated selective reduction of functioning collagen messenger ribonucleic acid
Rokowski, R. J., Sheehy, J., & Cutroneo, K. R. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90165-x · Cited by 62 · see citing works
Glucocorticoid receptors and glucocorticoid sensitivity of human leukemic cells
KONTULA, K. K., Andersson, L. C., Paavonen, T., Myllylä, G., Teerenhovi, L., & Vuopio, P. (1980) · International Journal of Cancer · doi:10.1002/ijc.2910260209 · Cited by 60 · see citing works
Glucocorticoid Receptors
Rousseau, G. G., & Baxter, J. D. (1979) · Monographs on endocrinology · doi:10.1007/978-3-642-81265-1_3 · Cited by 51 · see citing works
Glucocorticoids coordinately regulate procollagens type I and type III synthesis.
Shull, S., & Cutroneo, K. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32869-2 · Cited by 50 · see citing works
Collagen synthesis in human fibroblasts: Effects of ascorbic acid and regulation by hydrocortisone
Russell, S. B., Russell, J. D., & Trupin, K. M. (1981) · Journal of Cellular Physiology · doi:10.1002/jcp.1041090114 · Cited by 49 · see citing works
Cortisol decreases the concentration of translatable type-I procollagen mRNA species in the developing chick-embryo calvaria
Oikarinen, J., & Ryhänen, L. J. (1981) · Biochemical Journal · doi:10.1042/bj1980519 · Cited by 46 · see citing works
Self-citation
Effects of glucocorticosteroids on cultured human skin fibroblasts—IV
Ponec, M., Kempenaar, J. A., Harskamp, G. A. M.-V., & Bachra, B. N. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90562-8 · Cited by 45 · see citing works
Genetic approaches to cyclic AMP effects in cultured mammalian cells
Gottesman, M. M. (1980) · Cell · doi:10.1016/0092-8674(80)90342-6 · Cited by 37 · see citing works
Variation of (2′‐5′)Oligo(adenylate) Synthetase Activity during Rat‐Liver Regeneration
Smekens, M., GOLDSTEIN, J. P., Ooms, H., & Dumont, J. E. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07146.x · Cited by 37 · see citing works
Elevated levels of (2'-5')oligoadenylic acid polymerase activity in growth-arrested human lymphoblastoid Namalva cells.
Krishnan, I., & Baglioni, C. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.10.932 · Cited by 36 · see citing works
The Role of Glucocorticoid Hormones as Biological Amplifiers
Granner, D. K. (1979) · Monographs on endocrinology · doi:10.1007/978-3-642-81265-1_33 · Cited by 36 · see citing works
In Vitro Stabilization of the Unoccupied Glucocorticoid Receptor by Adenosine 5'-Diphosphate*
Barnett, C. A., Palmour, R. M., Litwack, G., & Seegmiller, J. E. (1983) · Endocrinology · doi:10.1210/endo-112-6-2059 · Cited by 29 · see citing works
Cortisol decreases the cellular concentration of translatable procollagen mRNA species in cultured human skin fibroblasts
Oikarinen, J., Pihlajaniemi, T. A., Hämäläinen, L., & Kivirikko, K. I. (1983) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(83)90148-3 · Cited by 20 · see citing works
Self-citation
The quantitative determination of deoxyribonucleoside triphosphates using high performance liquid chromatography
Ritter, E. J., & Bruce, L. M. (1979) · Biochemical Medicine · doi:10.1016/0006-2944(79)90050-4 · Cited by 18 · see citing works
Cortisol induces (2′–5′)oligoadenylate synthetase in cultured chick embryo tendon fibroblasts
Oikarinen, J. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91051-8 · Cited by 18 · see citing works
Self-citation
2',5'-Oligoadenylates and related 2',5'-oligonucleotide analogs. 2. Effect on cellular proliferation, protein synthesis, and endoribonuclease activity
Hughes, B. G., & Robins, R. K. (1983) · Biochemistry · doi:10.1021/bi00278a012 · Cited by 16 · see citing works
Glucocorticoids alter the ratio of type III/ type I collagen synthesis by mouse dermal fibroblasts
Verbruggen, L., & Abe, S. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90673-6 · Cited by 16 · see citing works

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Gruol, D. J., Campbell, N. F., & Bourgeois, S. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89191-3 · Cited by 94 · see citing works
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Durant, S., DUVAL, D., & Homo‐Delarche, F. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-3-254 · Cited by 86 · see citing works
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Okret, S., Dong, Y., Brönnegård, M., & Gustafsson, J.-Å. (1991) · Biochimie · doi:10.1016/0300-9084(91)90074-b · Cited by 86 · see citing works
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Haske, T., Nakao, M., & Moudgil, V. K. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00926925 · Cited by 24 · see citing works
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Sato, A., Sheppard, K. E., Fullerton, M., & Funder, J. W. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.5.e827 · Cited by 11 · see citing works
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Gruol, D. J., Ashby, M. N., Campbell, N. F., & Bourgeois, S. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90060-9 · Cited by 7 · see citing works
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Wasner, G., & Simons, S. S. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-1-109 · Cited by 7 · see citing works
In vitro transformation of androgen receptor from murine skeletal muscle by cAMP
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Glucocorticoid receptors in bovine adrenal medullary cells in culture: Regulation by cyclic nucleotides
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References
(2015) · Elsevier eBooks · doi:10.1016/b978-0-12-803321-0.09996-1
Neuroimmunology
Cutolo, M., & Trombetta, A. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814307-0.00055-4
Chronische Immunaktivierung
Straub, R. H. (2022) · Springer eBooks · doi:10.1007/978-3-662-65238-1_4
Chronic Immune System Activation
Straub, R. H. (2023) · Springer eBooks · doi:10.1007/978-3-662-66751-4_4
Molecular Mechanisms of Regulation of Gene Expression by Glucocorticoids
Dong, Y., Okret, S., & Gustafsson, J.-Α. (1993) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-77503-1_2
Phosphorylation Reactions Associated with the Glucocorticoid Receptor
Miller-Diener, A. S., Kirsch, T., Schmidt, T. J., & Litwack, G. (1987) · Springer eBooks · doi:10.1007/978-1-4613-2073-9_8
Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: Viewpoint based on a systemic pathogenetic role
Straub, R. H., & Cutolo, M. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200103)44:3

Glucocorticoids increase GTP-dependent adenylate cyclase activity in cultured fibroblasts.
Johnson, G. S., & Jaworski, C. (1983) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14309-5 · Cited by 29 · see citing works
Glucocorticoid receptors in bovine adrenal medullary cells in culture: Regulation by cyclic nucleotides
Betito, K., Diorio, J. C., Meaney, M. J., & Boksa, P. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90398-y · Cited by 6 · see citing works
Glucocorticoids: Effects on prostaglandin release, cyclic AMP levels and glycosaminoglycan synthesis in fibroblast tissue cultures
Peters, H. D., Peskar, B. A., & Sch�nh�fer, P. S. (1977) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00508464 · Cited by 18 · see citing works
Adrenal cells in tissue culture. VIII. Dissociation of the steroidogenic and glycolytic effects of cyclic nucleotides and adrenocorticotropin
Kowal, J. (1970) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02617761 · Cited by 2 · see citing works
Glucocorticoid receptor activation leads to up-regulation of adenosine A1 receptors and down-regulation of adenosine A2 responses in DDT1 MF-2 smooth muscle cells.
Gerwins, P., & Fredholm, B. B. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12919-2 · Cited by 58 · see citing works

Authors: Oikarinen, J., Hämäläinen, L., & Oikarinen, A.
Affiliations: University of Oulu (FI)
Venue: Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher: Elsevier BV
Published: 1984-06
Volume: 799
Issue: 2
Pages: 158-165
ISSN: 0304-4165 (ISSN-L)
DOI: 10.1016/0304-4165(84)90290-3
OpenAlex: W2080931570
Cited by: 62
References: 30
Citations by year: 2023: 1 · 2022: 1 · 2019: 1 · 2015: 3 · 2014: 2 · 2013: 1
FWCI: 2.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Keywords: glucocorticoid receptor, cyclic nucleotides, cyclic AMP, cyclic GMP, dermal fibroblasts, cortisol, 2',5'-oligoadenylate synthetase, 2',5'-oligoadenylate, protein synthesis, DNA synthesis, cell growth, receptor modulation
MeSH terms: Adenine Nucleotides, Cells, Cultured, Dexamethasone, Bucladesine, Dibutyryl Cyclic GMP, Fibroblasts, Cyclic GMP, Humans, Hydrocortisone, Oligoribonucleotides, Receptors, Glucocorticoid, Receptors, Steroid, Skin, Protein Biosynthesis, 2',5'-Oligoadenylate Synthetase

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Modulation of glucocorticoid receptor activity by cyclic nucleotides and its implications on the regulation of human skin fibroblast growth and protein synthesis

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