Serotonergic regulation of type II corticosteroid receptor binding in hippocampal cell cultures: Evidence for the importance of serotonin-induced changes in cAMP levels
Abstract
The development of the hypothalamic-pituitary-adrenal response to stress is profoundly altered by environmental events. One target for environmental regulation within the hypothalamic-pituitary-adrenal axis is the hippocampal type II corticosteroid (or glucocorticoid) receptor system, which mediates the negative-feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal activity. Thus, adult rats handled early in life show increased hippocampal type II corticosteroid receptor density and increased sensitivity to the inhibitory effects of circulating glucocorticoids on post-stress hypothalamic-pituitary-adrenal activity. Both effects persist throughout life. The effects of handling on type II corticosteroid receptor development are, at least in part, mediated by changes in hippocampal 5-hydroxytryptamine turnover. Moreover, 5-hydroxytryptamine can regulate type II corticosteroid receptor density in cultured hippocampal cells, providing a paradigm for examining the neurochemical mechanisms by which environmental stimuli might regulate neural differentiation. In the present studies, we examined the intracellular mechanisms underlying the effects of 5-hydroxytryptamine on type II corticosteroid receptors ([3H]RU 28362 binding) in hippocampal cell cultures. cAMP, but not cGMP, levels in cultured hippocampal cells were significantly increased by the addition of 5-hydroxytryptamine to the medium. The cAMP response to 5-hydroxytryptamine was biphasic: an initial increase i…
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In vivo, the effect on GR is blocked with 5-HT receptor antagonists.
“In vivo, the effect on GR is blocked with 5-HT receptor antagonists.80,81”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [80]
Maternal effects on hippocampal GR expression are mediated by increases in hippocampal serotonin turnover and expression of the NGFI-A transcription factor.
“In vivo studies with rat pups or in vitro studies using cultured hippocampal neurons suggest that maternal effects on hippocampal GR expression are mediated by increases in hippocampal serotonin (5-HT) turnover and the expression of the nerve-growth factor-inducible factor-A (NGFI-A) transcription factor.78-82”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [80]
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Self-citationMaternal regulation of pups’ cortical activity: role of serotonergic signaling
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Self-citation
- Authors
- Mitchell, J. B., Betito, K., Rowe, W., Boksa, P., & Meaney, M. J.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Meaney, M.J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1992-06
- Volume
- 48
- Issue
- 3
- Pages
- 631-639
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2076976729
- Cited by
- 84
- References
- 4
- Citations by year
- 2024: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- serotonin, glucocorticoid receptor, hippocampus, cyclic AMP, cyclic GMP, hypothalamic-pituitary-adrenal axis, glucocorticoid negative feedback, stress response, ketanserin
- MeSH terms
- Cyclic AMP, Mineralocorticoid Receptor Antagonists, Amphetamines, Animals, Cells, Cultured, Female, Hippocampus, Piperazines, Pregnancy, Receptors, Glucocorticoid, Serotonin, Serotonin Antagonists, Spironolactone, 8-Bromo Cyclic Adenosine Monophosphate, Second Messenger Systems, Rats
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