Cited by 110Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceCircadian rhythm and melatonin

The process of aging changes the interplay of the immune, endocrine and nervous systems

Straub, Rainer H, Cutolo, Maurizio, Zietz, Bettina, Schölmerich, Jürgen·2001·Mechanisms of Ageing and Development

Abstract

The immune, endocrine and nervous systems interact with each other by means of cytokines, hormones and neurotransmitters. Interaction is dependent on specific receptors and respective signaling pathways in target cells. During aging, changes occur on many levels of these global systems which depend on oxidative damage, non-enzymatic glycosylation, mitochondrial mutations, defects in cell cycle control, mitotic dysregulation, genome instability, telomere shortening and other chromosomal pathologies. An alteration of the numerical value of a parameter of one system can lead to changes of the numerical value of a variable of another system. In a non-linear dynamic process these changes can contribute to the aging phenotype. Although it is extremely difficult to dissect linear interrelations of three global systems during aging, this review attempts to identify some simple linear pathways. Furthermore, it is demonstrated that chronic inflammatory diseases may accelerate the aging process. This review also reveals that new statistical and computational methods are necessary to unravel the complexity of the aging process.

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Crossref · 10.1016/s0047-6374(01)00289-5

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Authors
Straub, R. H., Cutolo, M., Zietz, B., & Schölmerich, J.
Affiliations
  • University Hospital Regensburg (DE)
  • University of Genoa (IT)
Corresponding author
Straub, Rainer H
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
2001-09
Volume
122
Issue
14
Pages
1591-1611
ISSN
0047-6374 (ISSN-L)
OpenAlex
W1977047428
Cited by
110
References
101
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 10 · 2014: 3 · 2013: 5 · 2012: 7
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
aging, immune system, endocrine system, nervous system, cytokines, hormones, neurotransmitters, oxidative damage, glycation, mitochondrial mutations, cell cycle regulation, genomic instability, telomere shortening, chronic inflammation, aging phenotypes, nonlinear dynamics
MeSH terms
Aging, Animals, Chronic Disease, Endocrine System, Biological Evolution, Humans, Immune System, Nervous System Physiological Phenomena

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