Changes in 5-HT1 receptors in different brain structures of rats with isolation syndrome
Abstract
1. Prolonged (3 month) individual housing of Wistar rats produced aggressive muricidal behavior in 28% of the animals. 2. Binding studies with [3H]5-HT showed that the affinity (Kd) of 5-HT1 receptors in the frontal cortex, striatum, hippocampus and hypothalamus of isolated aggressive rats was significantly decreased as compared to that in grouped rats. 3. The affinity of 5-HT1 receptors was also significantly decreased in the striatum, hippocampus and hypothalamus of isolated nonaggressive rats. 4. The number (Bmax) of 5-HT1 receptors was significantly decreased in the hippocampus and hypothalamus of isolated aggressive rats and in isolated nonaggressive rats it was decreased only in the hypothalamus. 5. The data suggest that aggressive muricidal behavior in rats with syndrome of social isolation is connected with the decreased activity of brain 5-HT1 receptors.
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Chronic adolescent isolation in rodents (over 1 week or longer) has more profound effects, including hyper-reactivity to stress and increased aggression.
“When rodent adolescent isolation occurs chronically, over 1 week or longer, it has even more profound effects. Chronically isolated adolescent rodents (isolated throughout the whole adolescent period) have shown abnormal behaviours such as hyper-reactivity to stressful situations45 and increased aggression.46”
From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [46]
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The effects of social deprivation on adolescent development and mental health
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“Chronically isolated adolescent rodents (isolated throughout the whole adolescent period) have shown abnormal behaviours such as hyper-reactivity to stressful situations( 46 ) and increased aggression( 47 ).”
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- Authors
- Popova, J. S., & Petkov, V. V.
- Affiliations
- Bulgarian Academy of Sciences (BG)
- Corresponding author
- Popova, J.St.
- Venue
- General Pharmacology The Vascular System
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 21
- Issue
- 2
- Pages
- 223-225
- ISSN
- 0306-3623 (ISSN-L)
- OpenAlex
- W2038032637
- Cited by
- 40
- References
- 27
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- General Pharmacology The Vascular System (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- 5-HT1 receptors, serotonin receptors, social isolation, aggression, receptor binding affinity, receptor density, frontal cortex, striatum, hippocampus, hypothalamus
- MeSH terms
- Aggression, Animals, Brain, Kinetics, Male, Rats, Inbred Strains, Receptors, Serotonin, Social Isolation, Rats
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