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Cited by 130Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test

Maisonnette, S., Morato, S., Brandão, M.L.·1993·Physiology & Behavior
DOI 10.1016/0031-9384(93)90087-v
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Abstract

Rats were isolated for periods varying from 1 h to 2 weeks and the exploratory activity of these animals on the elevated plus-maze was studied. Rats isolated from periods of 2 h on displayed a significant reduction in the number of entries and time spent in the open arms of the plus-maze compared to socially housed controls. This effect was not correlated with the decrease in the total number of entries also produced by isolation. Acute treatment with midazolam or resocialization for a 24-h period clearly reversed these responses produced by prior 2-h isolation in the elevated plus-maze. It is suggested that exposure to a 2-h isolation period could be a useful nonpharmacological means of generating anxiety in laboratory rodents. Chronic treatment, but not acute treatment, with gepirone, a 5-HT1A agonist, inhibited the anxiogenic effects caused by a 2-week period of isolation. The reduction in aversiveness promoted by resocialization may be due to a recovery in the 5-HT activity depressed by isolation in a much faster way than observed with chronic gepirone administration.

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Crossref · 10.1016/0031-9384(93)90087-v

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  • Reintroducing acutely isolated animals to social contact can alleviate some short-term negative effects like anxiety, but long-lasting negative consequences remain.

    “Although reintroducing acutely isolated animals to social contact can alleviate some of the negative effects of short-term isolation, such as anxiety,40 there are long-lasting negative consequences that are not easily remedied. For example, increased ethanol consumption in animals after social isolation persists even after the reintroduction to social housing.44”

    From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [40]

  • In adolescent rodents, even brief isolation (e.g., 24 h) can cause increased anxiety, hyperactivity, heightened sensitivity to social rewards, and increased seeking of food or drug rewards, making them prone to addictions.

    “On a behavioural level, even a brief duration (eg, 24 h) of isolation in adolescent rodents can cause increased anxiety,40 hyperactivity,41 and heightened sensitivity to social rewards,42 which extends to the seeking of food or drug rewards, making these animals particularly prone to developing addictions.43”

    From The effects of social deprivation on adolescent development and mental health (2020) · cites this paper as [40]

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Authors
Maisonnette, S., Morato, S., & Brandão, M. L.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Brandão, M.L.
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
1993-10
Volume
54
Issue
4
Pages
753-758
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/0031-9384(93)90087-v
OpenAlex
W2068763416
Cited by
130
References
32
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 1
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
social isolation, anxiogenic effects, resocialization, 5-HT1A receptor, gepirone, midazolam, elevated plus maze, exploratory activity, anxiety models, serotonin, rats
MeSH terms
Animals, Anxiety, Exploratory Behavior, Male, Midazolam, Pyrimidines, Receptors, Serotonin, Serotonin Antagonists, Social Isolation, Anti-Anxiety Agents, Rats, Wistar, Serotonin Receptor Agonists, Rats

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