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Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

Pazos, A., Probst, A., Palacios, J.M.·1987·Neuroscience

DOI 10.1016/0306-4522(87)90327-7

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Abstract

The anatomical distribution of serotonin-2 receptors in the human brain was studied by light microscopic autoradiography, using [3H]ketanserin as a ligand. The receptor densities were quantified by microdensitometry with the aid of a computer-assisted image-analysis system. A heterogeneous distribution of serotonin-2 receptor densities was found in the human brain. Very high concentrations were localized over layers III and V of several cortical areas, including the frontal, parietal, temporal and occipital lobes, the anterogenual cortex and the entorhinal area, as well as in the corpus mamillare of the hypothalamus. The claustrum, nucleus lateralis of the amygdala and some cortical layers also presented a high density of serotonin-2 receptors. Intermediate concentrations were found over the hippocampus, the caudatus, putamen and accumbens nuclei, and some nuclei of the amygdala, among other structures. Areas such as the thalamus, brain stem, cerebellum and spinal cord contained, in general, only low to very low densities of serotonin-2 receptors. A very high level of non-specific binding, which was not displaceable by any serotonin-2 compound, was found in some areas of the human brain, including the caudatus and putamen nuclei, the substantia nigra and the raphé nuclei. The distribution of serotonin-2 receptors in the human brain described herein is discussed in relation to the distribution of serotonergic innervation, the central effects which have been proposed to be serotonin-2-mediated, and the neuropathological characteristics of the diseases where a modification in the number of serotonin-2 receptors has been reported.

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EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415
Molecular pathology of schizophrenia: more than one disease process?
Crow, T. J. (1980) · BMJ · doi:10.1136/bmj.280.6207.66 · Cited by 1,862
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Self-citation
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
Peroutka, S. J., & Snyder, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13812-1 · Cited by 1,363
Neurobiology of the hippocampus
Rawlins, J. N. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90113-1 · Cited by 1,097
Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding
Peroutka, S. J., & Snyder, S. H. (1980) · Science · doi:10.1126/science.6251550 · Cited by 837
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
Pazos, Á., Cortés, R., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90857-1 · Cited by 824
Self-citation
A new method for receptor autoradiography: [3H]Opioid receptors in rat brain
Young, W. S., & Kuhar, M. J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90442-6 · Cited by 797

Show all 75 references

Research works printed but not linked: 4

Blackshear, 1982, Serotonin receptors sensitivity after acute and chronic treatment with mianserin, J. Pharmac. exp. Ther., 221, 303
Braak, 1980, Architectonic of the human telencephalic cortex, Vol. 4
Harrison-Read, 1984, Noradrenergic and other strategies for devising new drug treatments of schizophrenia, Trends pharmac. Sci., 5, 139
Leysen, 1982, [3H]Ketanserin (R 41 468), a selective3H-ligand for serotonin2 receptor binding sites, Molec. Pharmac., 21, 301

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Biver, F., Lotstra, F., Monclus, M., Dethy, S., Damhaut, P., Wikler, D., Luxen, A., & Goldman, S. (1997) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(97)00054-1 · Cited by 24
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Self-citation
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Millson, D. S., Haworth, S. J., Rushton, A., Wilkinson, D., Hobson, S., & Harry, J. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb03929.x · Cited by 15
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Millson, D. S., Jessup, C. L., Swaisland, A. J., Haworth, S. J., Rushton, A., & Harry, J. (1992) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1992.tb04036.x · Cited by 14
Chemical neuroanatomy of the hippocampal formation and the perirhinal and parahippocampal cortices
Kobayashi, Y., & Amaral, D. G. (1999) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(99)80026-8 · Cited by 14
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Hurlemann, R., Matusch, A., Eickhoff, S. B., Palomero‐Gallagher, N., Meyer, P. T., Boy, C., Maier, W., Zilles, K., Amunts, K., & Bauer, A. (2005) · Anatomy and Embryology · doi:10.1007/s00429-005-0034-4 · Cited by 14
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Specific in vivo binding in the rat brain of [18F]RP 62203: A selective 5-HT2A receptor radioligand for positron emission tomography
Besret, L., Dauphin, F., Huard, C., Lasne, M., Vivet, R., Mickala, P., Barbelivien, A., & Baron, J. (1996) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(95)02008-x · Cited by 13
Cognition-induced modulation of serotonin in the orbitofrontal cortex: A controlled cross-over PET study of a delayed match-to-sample task using the 5-HT2a receptor antagonist [18F]altanserin
Hautzel, H., Müller, H., Herzog, H. R., & Grandt, R. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.009 · Cited by 13
Development of central 5-HT2A receptor radioligands for PET: Comparison of [3H]RP 62203 and [3H]SR 46349B kinetics in rat brain
Ashworth, S., Hume, S. P., Lammertsma, A. A., Opacka‐Juffry, J., Shah, F., & Pike, V. W. (1996) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(95)02053-5 · Cited by 12
Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats
Martin, S., Lino‐de‐Oliveira, C., Joca, S. R. L., de Oliveira, R. W., Echeverry, M. B., Silva, C. A., Pardo, L. A., Stühmer, W., & Bel, E. D. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00632.x · Cited by 12
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Matsumoto, R. R., Hussong, M. J., & Truong, D. D. (1995) · Movement Disorders · doi:10.1002/mds.870100514 · Cited by 10
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Beitz, A. J. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-547625-6.50018-0 · Cited by 10
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Leslie, R. A., & Reynolds, D. J. (1991) · doi:10.1007/978-1-349-12272-1_3 · Cited by 9
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Stephenson, J. D. (1990) · International Review of Psychiatry · doi:10.3109/09540269009028280 · Cited by 6
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Price, J. C., Lopresti, B. J., Mason, N. S., Huang, Y. H., Holt, D. P., Smith, G. S., & Mathis, C. A. (1998) · Elsevier eBooks · doi:10.1016/b978-012161340-2/50066-4 · Cited by 6

Authors: Pazos, A., Probst, A., & Palacios, J. M.
Affiliations: University of Basel (CH)
Sandoz Group AG (Switzerland) (CH)
Corresponding author: Palacios, J.M.
ORCID: Palacios, J.M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1987-04
Volume: 21
Issue: 1
Pages: 123-139
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(87)90327-7
OpenAlex: W4319425390
Cited by: 355
References: 75
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 14 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 4
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: serotonin 2 receptor, human brain, receptor distribution, entorhinal area, hippocampus, basal ganglia, substantia nigra, raphe nuclei, non-specific binding, serotonergic innervation, neurodegenerative diseases

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Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

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