Cited by 355Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 71 of the 75 references it cites were found in a registry or an index.

Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

Pazos, A., Probst, A., Palacios, J.M.·1987·Neuroscience

DOI 10.1016/0306-4522(87)90327-7

Open this paper in CoChat — free account

Abstract

The anatomical distribution of serotonin-2 receptors in the human brain was studied by light microscopic autoradiography, using [3H]ketanserin as a ligand. The receptor densities were quantified by microdensitometry with the aid of a computer-assisted image-analysis system. A heterogeneous distribution of serotonin-2 receptor densities was found in the human brain. Very high concentrations were localized over layers III and V of several cortical areas, including the frontal, parietal, temporal and occipital lobes, the anterogenual cortex and the entorhinal area, as well as in the corpus mamillare of the hypothalamus. The claustrum, nucleus lateralis of the amygdala and some cortical layers also presented a high density of serotonin-2 receptors. Intermediate concentrations were found over the hippocampus, the caudatus, putamen and accumbens nuclei, and some nuclei of the amygdala, among other structures. Areas such as the thalamus, brain stem, cerebellum and spinal cord contained, in general, only low to very low densities of serotonin-2 receptors. A very high level of non-specific binding, which was not displaceable by any serotonin-2 compound, was found in some areas of the human brain, including the caudatus and putamen nuclei, the substantia nigra and the raphé nuclei. The distribution of serotonin-2 receptors in the human brain described herein is discussed in relation to the distribution of serotonergic innervation, the central effects which have been proposed to be serotonin-2-mediated, and the neuropathological characteristics of the diseases where a modification in the number of serotonin-2 receptors has been reported.

Integrity signals

Registry

Crossref · 10.1016/0306-4522(87)90327-7

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
A PROPOSED MECHANISM OF EMOTION
PAPEZ, J. W. (1937) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1937.02260220069003 · Cited by 3,563
Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals
Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415
Molecular pathology of schizophrenia: more than one disease process?
Crow, T. J. (1980) · BMJ · doi:10.1136/bmj.280.6207.66 · Cited by 1,862
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Self-citation
Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
Peroutka, S. J., & Snyder, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13812-1 · Cited by 1,363
Neurobiology of the hippocampus
Rawlins, J. N. P. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90113-1 · Cited by 1,097
Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding
Peroutka, S. J., & Snyder, S. H. (1980) · Science · doi:10.1126/science.6251550 · Cited by 837
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
Pazos, Á., Cortés, R., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90857-1 · Cited by 824
Self-citation
A new method for receptor autoradiography: [3H]Opioid receptors in rat brain
Young, W. S., & Kuhar, M. J. (1979) · Brain Research · doi:10.1016/0006-8993(79)90442-6 · Cited by 797

Show all 75 references

Research works printed but not linked: 4

Blackshear, 1982, Serotonin receptors sensitivity after acute and chronic treatment with mianserin, J. Pharmac. exp. Ther., 221, 303
Braak, 1980, Architectonic of the human telencephalic cortex, Vol. 4
Harrison-Read, 1984, Noradrenergic and other strategies for devising new drug treatments of schizophrenia, Trends pharmac. Sci., 5, 139
Leysen, 1982, [3H]Ketanserin (R 41 468), a selective3H-ligand for serotonin2 receptor binding sites, Molec. Pharmac., 21, 301

Sorted by citations

Items 301–355 of 355

A cell-permeable fluorescent probe reveals temporally diverse PI(4,5)P2 dynamics evoked by distinct GPCR agonists in neurons
Kundu, R., Mondal, S., Kapadia, A., Banerjee, A. A., Kucherak, O. A., Klymchenko, A. S., Koushika, S. P., Venkatramani, R., Vaidya, V. A., & Datta, A. (2025) · Chemical Science · doi:10.1039/d5sc01306b · Cited by 5
History of psychedelic drug science and molecular pharmacology
Nichols, D. E., & Nichols, C. D. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.02.001 · Cited by 5
Functional Organization of Dorsal Horn Interneurons
Willis, W. D., & Coggeshall, R. E. (2004) · Springer eBooks · doi:10.1007/978-1-4615-0035-3_7 · Cited by 5
Synthesis, radiosynthesis and in vivo evaluation in mice of [123I]-(4-fluorophenyl) {1-[2-(4-iodophenyl)ethyl]piperidin-4-yl}methanone for visualization of the 5-HT2A receptor with SPECT
Blanckaert, P., Burvenich, I. J. G., Staelens, L., Dierckx, R. A., & Slegers, G. (2004) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2004.10.008 · Cited by 5
Chapter 5 Receptor localization in the human hypothalamus
Palacios, J. M., Probst, A., & Mengod, G. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)64563-x · Cited by 5
Self-citation
The central antihypertensive action of 5-hydroxytryptamine: The location of site of action
Coote, J. H. (1990) · Springer eBooks · doi:10.1007/978-94-009-0479-8_19 · Cited by 5
The Making of the 5-HT2C Receptor
Palacios, J. M., Pazos, Á., & Hoyer, D. (2010) · The Receptors · doi:10.1007/978-1-60761-941-3_1 · Cited by 4
Self-citation
5-HT2A Receptors in the Basal Ganglia
Miguélez, C., Morera-Herreras, T., & Deurwaerdère, P. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-70474-6_12 · Cited by 2
Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes
Li, H. Q., Xu, J. Y., Gao, Y., & Jin, L. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.030 · Cited by 4
Mapping the primate thalamus: systematic approach to analyze the distribution of subcortical neuromodulatory afferents
Pérez-Santos, I., García‐Cabezas, M. Á., & Cavada, C. (2023) · Brain Structure and Function · doi:10.1007/s00429-023-02619-w · Cited by 5
The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with 123I-R91150 SPECT
Adriaens, A., Polis, I., Vermeire, S. T., Waelbers, T., Croubels, S., Duchateau, L., Dorpe, S. V., Eersels, J. L. H., Spiegeleer, B. M. J. D., & Peremans, K. Y. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.004 · Cited by 4
The role of serotonergic receptors in the effects ofmu opioids in squirrel monkeys responding under a titration procedure
Powell, K. R., & Dykstra, L. A. (1996) · Psychopharmacology · doi:10.1007/bf02246409 · Cited by 4
A unique phenotype of 5‐HT2C, agonist‐induced GTPγ35S binding, transferable to 5‐HT2A and 5‐HT2B, upon swapping intracellular regions
Alberts, G. L., Chio, C. L., Im, W. B., & Slightom, J. L. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705058 · Cited by 4
Combining machine learning, molecular dynamics, and free energy analysis for (5HT)-2A receptor modulator classification
Yu, X., Eid, Y., Jama, M., Pham, D., Ahmed, M., attar, M. S., Samiuddin, Z., & Barakat, K. (2024) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2024.108842 · Cited by 3
Serotonin Receptors in Areas of the Emotion Regulation Network in Human and Rat Brains—A Comparative Autoradiographic Study
Kuckertz, A., Zhao, L., Kedo, O., Amunts, K., & Palomero‐Gallagher, N. (2025) · The Journal of Comparative Neurology · doi:10.1002/cne.70068 · Cited by 3
Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET-derived features
Dörfel, R. P., Arenas‐Gomez, J. M., Svarer, C., Ganz, M., Knudsen, G. M., Svensson, J. E., & Plavén‐Sigray, P. (2024) · GeroScience · doi:10.1007/s11357-024-01148-6 · Cited by 3
Mediators of the Nervous System Kinds Characteristic
Bon, E. I. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.48.007692 · Cited by 3
Serotonin receptor imaging by 18F-PET
Billard, T., Liger, F., & Verdurand, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812733-9.00013-1 · Cited by 3
The Role of Serotonin on Attentional Processes and Executive Functioning: Focus on 5-HT2C Receptors
Tsaltas, E., & Boulougouris, V. (2010) · The Receptors · doi:10.1007/978-1-60761-941-3_23 · Cited by 2
Mechanisms of upper airway hypotonia
Kubin, L. K., & Davies, R. O. (2011) · Informa Healthcare eBooks · doi:10.3109/9781420020885.004 · Cited by 2
Simplified analogues of ritanserin and their affinity at 5-HT2A, 5-HT2B and 5-HT2C serotonin receptors
Claudi, F., Scoccia, L., Giorgioni, G., Marucci, G., Stefano, A. D., Gessi, S., Siniscalchi, A., & Borea, P. A. (1998) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(98)80029-9 · Cited by 2
Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposurePreprint
Hsiao, Y., Fonseca, M. A., Tiemroth, A. S., Vasquez, E. J., & Gomez, A. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.16.633439 · Cited by 2
Class A GPCR: Serotonin Receptors
Grinde, E., & Herrick‐Davis, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-60174-8_6 · Cited by 1
Substances of Abuse and Hallucinogenic Activity: The Serotoninergic Pathway - Focus on Classical Hallucinogens and Entactogens
Lazzaretti, M., Mandolini, G. M., Altamura, A. C., & Brambilla, P. (2018) · Springer eBooks · doi:10.1007/978-3-319-75124-5_2 · Cited by 1
Psilocybin-gestützte Therapie von Depression, Angst und Suchtstörungen: Neurobiologische Grundlagen und klinische Anwendung
Lasch, A., Schweikert, T., Dora, E., Kolb, T., Schurig, H. L., & Walther, A. (2023) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-2046-5202 · Cited by 1
Chapter 18 Some views on the influence of morphine on brain stem pain modulating neurons and descending controls acting on the spinal cord
Dickenson, A. H. (1988) · Progress in brain research · doi:10.1016/s0079-6123(08)62793-4 · Cited by 1
Atypical Antipsychotic Drugs: Mechanism of Action
Meltzer, H. Y. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn034 · Cited by 1
Effect of serotonin on neuronal background activity in a hemisegment isolated from the infant rat spinal cord
Khasabov, S. G., & Tamarova, Z. A. (1990) · Neurophysiology · doi:10.1007/bf01058223 · Cited by 1
Bildliche Darstellung von Neurotransmitterinteraktionen in vivo mittels PET
Smith, G. S., Dewey, S. L., Brodie, J. D., Bartlett, E. J., Simkowitz, P., Riedel, R., Fujita, H., Cancro, R., & Wolf, A. P. (1995) · Springer eBooks · doi:10.1007/978-3-642-79738-5_7 · Cited by 1
Serotonin Systems
Gray, J. A., & Roth, B. L. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn008 · Cited by 2
Is the 5-HT2-Receptor a Target for Antipsychotic Drug Action? PET Studies on Dopamine (D2 and Serotonin (5-HT2) Receptor Occupancy in Patients and Healthy Subjects
Nyberg, S., Nordström, A., Halldin, C., & Farde, L. (1995) · Springer eBooks · doi:10.1007/978-94-011-0429-6_8
Functional Brain Imaging in the Dog: Perfusion and Serotonin-2A Receptor Imaging in Physiological and Pathophysiological Conditions
Peremans, K. Y., Audenaert, K., Otte, A., van Bree, H., van Heeringen, K., & Dierckx, R. A. J. O. (2004) · Springer eBooks · doi:10.1007/978-3-642-18773-5_10
5-HT2 agents in anxiety
Meert, T. F., & Leysen, J. E. (1991) · European Neuropsychopharmacology · doi:10.1016/0924-977x(91)90488-g
5-HT2C Receptors in Learning
Ángel, L.-V. M., Gutiérrez-Guzmán, B. E., Cervantes, M., & Olvera‐Cortés, M. E. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-941-3_24
Serotonin and stress responding in animals: role of 5-HT.2A/C receptors in the central and peripheral nervous systems
Uzelac, S. (2005) · doi:10.31390/gradschool_dissertations.3145
Anti Leishmanial Activities of Some Antidepressant Drugs and Antifungal Drugs.
Trivedi, S., Lodhi, G. N., Doifode, C. A., & Raut, H. I. (2017) · Journal of Advance Research in Pharmacy & Biological Science · doi:10.53555/nnpbs.v3i4.697
Neurotransmitters
Faull, K. F. (1992) · Springer eBooks · doi:10.1007/978-1-4899-1173-5_5
Response
Joyce, J. N. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.62
Molecular mechanisms underlying cannabis-induced risk of psychosis
Unzueta‐Larrinaga, P., Callado, L. F., & Urigüen, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823490-7.00004-6
Anti Leishmanial Activities of Some Antidepressant Drugs And Antifungal Drugs
Trivedi, S., Lodhi, G. N., Doifode, C. A., & Raut, H. I. (2017) · Journal of Advance Research in Business Management and Accounting · doi:10.53555/nnbma.v3i4.487
Combining Machine Learning, Molecular Dynamics, and Free Energy Analysis for (5ht)-2a Receptor Modulator ClassificationPreprint
Barakat, K., Yu, X., Eid, Y., Jama, M., Pham, D., Ahmed, M., & Attar, M. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4758294
Focal pharmacological manipulation of serotonin signaling in the amygdala does not alter social behavior
Jacobs, J. T., Maior, R. S., Waguespack, H. F., Campos-Rodríguez, C., Málková, L., & Forcelli, P. A. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06651-4
Psilocybin-gestützte Therapie von Depression, Angst und Suchtstörungen: Neurobiologische Grundlagen und klinische Anwendung
Lasch, A., Schweikert, T., Dora, E., Kolb, T., Schurig, H. L., & Walther, A. (2025) · Nervenheilkunde · doi:10.1055/a-2517-1621
Psychedelic agents for treatment-resistant depression
Gukasyan, N., & Griffiths, R. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824067-0.00014-1
Candidate gene studies of suicidal behavior-2: in relation to serotonergic polymorphisms
Kundu, S. R., & Sarkar, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33112-1.00007-0
Localization of 5-HT receptors in the mammalian cortex
Santana, N., de Almeida, J., Mengod, G., & Artigas, F. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8561-3_5
Targeting serotonin 5-HT2A receptors in the treatment of aggression: From antipsychotics to psychedelics
Scheggi, S., Braccagni, G., Branca, C., & Bortolato, M. (2026) · Aggression and Violent Behavior · doi:10.1016/j.avb.2026.102139
Implication de l'activité constitutive des récepteurs 5-HT4 dans la régulation de la conduite alimentaire : vers une solution thérapeutique
Laurent, L. (2011) · theses.fr (ABES) · doi:10.70675/bd5b3ce9z6d45z4719zb866z1b7205d79917
AMPc et prise alimentaire sous le contrôle des récepteurs 5-HT4 de la sérotonine dans le noyau accumbens
Pratlong, M. (2014) · theses.fr (ABES) · doi:10.70675/02dafa47zd1cfz49e6z86a9zb57e2f9d693f
Receptor subtype distribution from PET occupancy studies: Novel analysis of maximum occupancy images using a selective drug and a non-selective tracer
Kim, S. J., Ibrahimy, A., Constantinescu, C. C., Hoye, J., Searle, G. E., Slifstein, M., Rabiner, E. A., & Morris, E. D. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261438226
Impact of Psilocybin on Motor Function in Healthy Participants: A Phase 1, Randomised, Triple-Blind, Dose-Finding Study
Bhagavan, C., Carter, O. L., Nielsen, G., Berlowitz, D. J., Issak, S., Braat, S., Zaloumis, S. G., Attard, Z., Oliver, G., Mayne, D., et al. (2026) · CNS Drugs · doi:10.1007/s40263-026-01326-4 · Cited by 2
An Open‐Label Study Investigating the 5‐HT 2A Receptor Occupancy of Remlifanserin (ACP‐204) With the PET Radioligand [ 18 F]Altanserin in Healthy Male Participants
Burstein, E. S., Sandiego, C., Raether, B., Feng, X., Dirks, B., Darwish, M., Zhang, P., Russell, D. S., Rabiner, E. A., & Pathak, S. (2026) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.70096
Evaluation of the Effects of Different Doses of Ayahuasca on Intelligence and Verbal Memory in Healthy Volunteers
de Paula, C. C., Vicentini, A. B., Guerra, L. T. L., Maekawa, R. M., Reis, J. A. S., Villanova, B., Gomes, C. C., Bellucci, T., Rossi, G. N., Bouso, J. C., et al. (2026) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000002267
BindingDB Entry 4885: PET examination of [11C]NNC 687 and [11C]NNC 756 as new radioligands for the D1-dopamine receptor.
BindingDB (2011) · UC San Diego · doi:10.7270/q29p3047
Bedeutung des serotoninergen Systems für die Pathophysiologie der Migräne
Limmroth, V., & Diener, H. (1994) · Springer eBooks · doi:10.1007/978-3-642-93522-0_13

Authors: Pazos, A., Probst, A., & Palacios, J. M.
Affiliations: University of Basel (CH)
Sandoz Group AG (Switzerland) (CH)
Corresponding author: Palacios, J.M.
ORCID: Palacios, J.M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1987-04
Volume: 21
Issue: 1
Pages: 123-139
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(87)90327-7
OpenAlex: W4319425390
Cited by: 355
References: 75
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 14 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 4
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: serotonin 2 receptor, human brain, receptor distribution, entorhinal area, hippocampus, basal ganglia, substantia nigra, raphe nuclei, non-specific binding, serotonergic innervation, neurodegenerative diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks