The DOI matches its Crossref record; 148 of the 150 references it cites were found in a registry or an index.
An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex
Abstract
The distribution of cholinergic fibers in rat cortex was investigated using choline acetyl-transferase immunohistochemistry. Previous studies have either shown differences in distribution, but have been limited to selected areas, or have shown no discernable differences between different cortical areas. In our study, we examined all areas of rat cortex and found that there are striking interareal and interlaminar differences in cholinergic fiber distribution. We have found that certain functionally similar cortical areas (e.g. sensory, motor, etc.) have similar patterns of cholinergic innervation and we have designated 13 general patterns of cortical cholinergic innervation. We have also compared, on an area-by-area basis, the pattern of acetylcholinesterase reactivity to that of choline acetyltransferase immunoreactivity, since acetylcholinesterase has been used for many years as a putative cholinergic marker. We found that in most cortical areas, the distribution of acetylcholinesterase-positive fibers paralleled that of choline acetyltransferase-immunoreactive fibers; however, there were some striking differences, notably primary somatosensory (the "barrelfield"), retrosplenial and cingulate cortices. In some areas, a revised concept of rat cortical organization, using cytoarchitectonics, was required. The results of this study provide a comprehensive microscopic analysis of cholinergic fiber innervation of the rat cortex. These results are discussed in relation to previous anatomical, physiological and pharmacological studies of cortical cholinergic innervation. The possible sources of this innervation are also discussed.
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“The entire cortex and hippocampus are innervated by cholinergic projections that originate from several regions in the basal forebrain (Rye et al, 1984; Lysakowski et al, 1989; Mesulam et al, 1992; Kitt et al, 1994).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Lysakowski et al, 1989
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Galvin, V. C., Arnsten, A. F. T., & Wang, M. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00067 · Cited by 25
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Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
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Metadata
- Authors
- Lysakowski, A., Wainer, B. H., Bruce, G., & Hersh, L. B.
- Affiliations
- University of Chicago (US)
- University of Texas Health Science Center at Dallas (US)
- Corresponding author
- Lysakowski, A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 28
- Issue
- 2
- Pages
- 291-336
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W1969045806
- Cited by
- 239
- References
- 150
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 7 · 2012: 5
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32ns007195-10)
- National Institute of Neurological Disorders and Stroke (5T32 NS-07195, NS 17661)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 04583)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- choline acetyltransferase, acetylcholinesterase, cholinergic innervation, cerebral cortex, laminar distribution, cortical cytoarchitecture, barrel cortex, retrosplenial cortex, cingulate cortex, rats
- MeSH terms
- Animals, Brain Mapping, Cerebral Cortex, Choline O-Acetyltransferase, Electrophysiology, Histocytochemistry, Immunohistochemistry, Parasympathetic Nervous System, Rats, Inbred Strains, Tissue Distribution, Rats
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