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Cited by 239Neuroscience and Neuropharmacology ResearchCholinesterase and Neurodegenerative DiseasesNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 148 of the 150 references it cites were found in a registry or an index.

An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex

Lysakowski, A., Wainer, B.H., Bruce, G., Hersh, L.B.·1989·Neuroscience
DOI 10.1016/0306-4522(89)90180-2
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Abstract

The distribution of cholinergic fibers in rat cortex was investigated using choline acetyl-transferase immunohistochemistry. Previous studies have either shown differences in distribution, but have been limited to selected areas, or have shown no discernable differences between different cortical areas. In our study, we examined all areas of rat cortex and found that there are striking interareal and interlaminar differences in cholinergic fiber distribution. We have found that certain functionally similar cortical areas (e.g. sensory, motor, etc.) have similar patterns of cholinergic innervation and we have designated 13 general patterns of cortical cholinergic innervation. We have also compared, on an area-by-area basis, the pattern of acetylcholinesterase reactivity to that of choline acetyltransferase immunoreactivity, since acetylcholinesterase has been used for many years as a putative cholinergic marker. We found that in most cortical areas, the distribution of acetylcholinesterase-positive fibers paralleled that of choline acetyltransferase-immunoreactive fibers; however, there were some striking differences, notably primary somatosensory (the "barrelfield"), retrosplenial and cingulate cortices. In some areas, a revised concept of rat cortical organization, using cytoarchitectonics, was required. The results of this study provide a comprehensive microscopic analysis of cholinergic fiber innervation of the rat cortex. These results are discussed in relation to previous anatomical, physiological and pharmacological studies of cortical cholinergic innervation. The possible sources of this innervation are also discussed.

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Crossref · 10.1016/0306-4522(89)90180-2

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Citations

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Show all 150 references

Research works printed but not linked: 15

  1. Eckenstein, 1985, An immunohistochemical analysis of cholinergic innervation in the cerebral cortex, Soc. Neurosci. Abstr., 11, 864
  2. Koralek, 1985, Projections of the medial portion of the posterior thalamic nuclear group (POM) to the somatosensory cortex of the rat, Soc. Neurosci. Abstr., 11, 905
  3. Krnjević, 1965, A histochemical study of cholinergic fibers in the cerebral cortex, J. Anat., Lond., 99, 711
  4. Lysakowski, 1985, Cholinergic cortical innervation: a correlative study of choline acetyltransferase-immunoreactive versus acetylcholinesterase-positive fiber distribution, Soc. Neurosci. Abstr., 11, 979
  5. Lysakowski, 1986, Cortical cholinergic fibers show ten distinct regional lamination patterns, Soc. Neurosci. Abstr., 12, 355
  6. Millar, 1985, [Met]-enkephalin.Arg6.Phe7 can be converted to [Met]-enkephalin immunoreactive material by acetylcholinesterase, Neurosci. Lett. Suppl., 19, S86
  7. O'Neill, 1985, Distributions of nicotinic and muscarinic cholinergic receptors in monkey cerebral cortex, Soc. Neurosci. Abstr., 11, 1053
  8. Palacios, 1986, Mapping of subtypes of muscarinic receptors in the human brain with receptor autoradiographic techniques, Trends pharmac. Sci. Suppl., 56
  9. Rose, 1912, Histologische Legalisation der Grosshirnrinde bei kleinen Säugetieren (Rodentia, Insectivora, Chiroptera), J. Psychol. Neurol., 19, 389
  10. Rose, 1929, Cytoarchitektonischer Atlas der Grosshirnrinde der Maus, J. Psychol. Neurol., 40, 1
  11. Spencer, 1985, Direct autoradiographic determination of muscarinic M1 and M2 receptor sub-type distribution in the rat brain: relative binding patterns in cholinergic nuclei and projection areas, Soc. Neurosci. Abstr., 11, 1054
  12. Storm-Mathisen, 1984, Neurotransmitters in the hippocampal formation, Vol. 11, 105
  13. Webster, 1985, Auditory system, Vol. 2, 153
  14. Zhu, 1984, Acetylcholinesterase and somatostatin immunoreactivity coexist in neurons in rat cerebral cortex and hippocampus, but not in Ch4 cholinergic neurons of the basal forebrain, Soc. Neurosci. Abstr., 10, 696
  15. Zilles, 1985, Cortex: areal and laminar structure, Vol. 1, 375

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Metadata

Authors
Lysakowski, A., Wainer, B. H., Bruce, G., & Hersh, L. B.
Affiliations
  • University of Chicago (US)
  • University of Texas Health Science Center at Dallas (US)
Corresponding author
Lysakowski, A.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
1989-01
Volume
28
Issue
2
Pages
291-336
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/0306-4522(89)90180-2
OpenAlex
W1969045806
Cited by
239
References
150
Citations by year
2026: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 8 · 2013: 7 · 2012: 5
FWCI
4.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5t32ns007195-10)
  • National Institute of Neurological Disorders and Stroke (5T32 NS-07195, NS 17661)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 04583)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
choline acetyltransferase, acetylcholinesterase, cholinergic innervation, cerebral cortex, laminar distribution, cortical cytoarchitecture, barrel cortex, retrosplenial cortex, cingulate cortex, rats
MeSH terms
Animals, Brain Mapping, Cerebral Cortex, Choline O-Acetyltransferase, Electrophysiology, Histocytochemistry, Immunohistochemistry, Parasympathetic Nervous System, Rats, Inbred Strains, Tissue Distribution, Rats

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