Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices
Abstract
The effect of 5-hydroxytryptamine on the induction of long-term potentiation by a train of high frequency pulses (100 Hz; 1 s) or by a stimulation consisting of one burst of five pulses at 100 Hz delivered 170 ms after a single pulse (primed burst) was investigated in the CA1 region of the rat hippocampal slice in vitro with extracellular recordings. Superfusion with 5-hydroxytryptamine (3-30 microM) produced a concentration-dependent decrease in amplitude of the population spikes evoked by test stimuli. The presence of 5-hydroxytryptamine (30 microM) did not affect the magnitude of long-term potentiation produced by the high-frequency stimulation but it prevented the long-term potentiation induced by a primed burst. The action of 5-hydroxytryptamine was mimicked by the 5-hydroxytryptamine1A agonist 5-carboxamidotryptamine (0.3 microM) and blocked by the 5-hydroxytryptamine2/5-hydroxytryptamine1A antagonist spiperone (3 microM) or by the 5-hydroxytryptamine1/5-hydroxytryptamine2 antagonist methiothepin (1-10 microM). The selective 5-hydroxytryptamine2 antagonist ritanserin (1 microM) did not antagonize the block of long-term potentiation produced by 5-hydroxytryptamine. The selective 5-hydroxytryptamine3 antagonists (3-tropanyl)-1H-indole-3-carboxylic acid ester (ICS 205-930; 1 nM) and ondansetron (GR-38032; 30 nM) did not affect the reduction in the population spike produced by application of 5-hydroxytryptamine. In contrast, a primed burst delivered at the fifth minute of 5-hydroxytryptamine application in the presence of a 5-hydroxytryptamine3 antagonist induced a long-term potentiation.(ABSTRACT TRUNCATED AT 250 WORDS)
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Stress or stress-related neuromodulators block LTP produced by relatively weak (primed burst or theta burst) tetanizing stimulation, but stress has no effect on LTP produced by stronger forms of tetanizing stimulation.
“Moreover, in electrophysiological studies, stress or stress-related neuromodulators have been shown to block LTP produced by relatively weak (primed burst or theta burst) tetanizing stimulation, but stress has been shown to have no effect on LTP produced by stronger forms of tetanizing stimulation (Corradetti et al. [283]; Mesches et al. [51]; Diamond et al. [139]; Alfarez et al. [152]; Vouimba et”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Corradetti et al. [283]
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“…by relatively weak (primed burst or theta burst) tetanizing stimulation, but stress has been shown to have no e ff ect on LTP produced by stronger forms of tetanizing stimulation (Corradetti et al. [283]; Mesches et al. [51]; Diamond et al. [139]; Alfarez et al. [152]; Vouimba et al. [140]).”
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Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
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- Authors
- Corradetti, R., Ballerini, L., Pugliese, A. M., & Pepeu, G.
- Affiliations
- University of Florence (IT)
- Corresponding author
- Corradetti, R.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1992-02
- Volume
- 46
- Issue
- 3
- Pages
- 511-518
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2047193867
- Cited by
- 141
- References
- 2
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 9 · 2013: 3 · 2012: 1
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- SDL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonin, long-term potentiation, hippocampal CA1, 5-HT1A receptor, 5-HT3 receptor, 5-HT2 receptor, 5-carboxamidotryptamine, spiperone, methiothepin, ritanserin, tropisetron, ondansetron, high-frequency stimulation
- MeSH terms
- Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Male, Rats, Inbred Strains, Receptors, Serotonin, Serotonin, Serotonin Antagonists, Rats, In Vitro Techniques
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