Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents
Open accessAbstract
Acute inescapable stress dramatically affects the inducibility of plasticity at glutamatergic synapses in the intact hippocampus. The present study examined the involvement of serotonergic mechanisms in mediating and modulating the block of long-term potentiation (LTP) in the CA1 area of anesthetized rats after exposure to an elevated platform stress. Fluoxetine and fenfluramine, agents that raise hippocampal extracellular 5-HT concentration, blocked the induction of LTP in nonstressed animals, thus mimicking the effect of stress. In contrast, (+/-)-tianeptine, a drug that decreases 5-HT levels, had no effect on LTP induction in nonstressed animals. Remarkably, (+/-) administration of tianeptine after the stress rapidly overcame the block of LTP induction without affecting baseline excitatory transmission. Consistent with a reduction of 5-HT levels being responsible for this effect of tianeptine, the (-) enantiomer, which is associated with the 5-HT uptake enhancing action of (+/-)-tianeptine, also caused a recovery of the induction of LTP in previously stressed animals, whereas the relatively inactive (+) enantiomer had no effect. Furthermore, fluoxetine prevented the effect of tianeptine in stressed animals. These findings show that antidepressants have rapid and powerful interactions with the mechanisms controlling the persistence of the block of LTP by inescapable stress.
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Dysfunction of synaptic plasticity with neuronal atrophy and cell death contributes to the pathophysiology of depression.
“While synaptic plasticity is a well-known key mechanism in learning and memory (Dayan and Cohen, 2011;Kandel, 2001), unequivocal studies suggest that dysfunction of synaptic plasticity with neuronal atrophy and cell death contribute to the pathophysiology of depression and therapeutic response could be associated with overcoming this deficit (Duman and Aghajanian, 2012;Krystal et al., 2013;Shakesb”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Shakesby et al., 2002
The LTP induction in stressed animals section reports that tianeptine restored hippocampal synaptic plasticity impaired by stress in rats. The Discussion connects hippocampal dysfunction to aspects of affective disorders and mentions stress-related dendritic atrophy, but it does not establish neuronal cell death or show that these changes cause depression. Page numbers were not available for these passages. (LLM, conf=0.84)
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Cites
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250 · see citing works
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,150 · see citing works
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works
Stress and glucocorticoids impair retrieval of long-term spatial memory
de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L. (1998) · Nature · doi:10.1038/29542 · Cited by 1,182 · see citing works
Czéh, B., Michaelis, T., Watanabe, T., Frahm, J., de Biurrun, G., van Kampen, M., Bartolomucci, A., & Fuchs, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427898 · Cited by 1,090 · see citing works
Role of 5-HT in stress, anxiety, and depression
Graeff, F. G., Guimarães, F. S., De Andrade, T. G. C. S., & Deakin, J. F. W. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02135-3 · Cited by 984 · see citing works
A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat
Vertes, R. P. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903130409 · Cited by 842 · see citing works
Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1321 · Cited by 784 · see citing works
Glucocorticoids and the regulation of memory consolidation
Roozendaal, B. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00058-x · Cited by 665 · see citing works
Neuronal plasticity and survival in mood disorders
Duman, R. S., Malberg, J., Nakagawa, S., & D’Sa, C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00935-5 · Cited by 652 · see citing works
Kim, J. J., Lee, H. J., Han, J.-S., & Packard, M. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05222.2001 · Cited by 537 · see citing works
Behavioural stress facilitates the induction of long-term depression in the hippocampus
Xu, L., Anwyl, R., & Rowan, M. J. (1997) · Nature · doi:10.1038/387497a0 · Cited by 509 · see citing works
Self-citationInescapable versus escapable shock modulates long-term potentiation in the rat hippocampus
Shors, T. J., Seib, T. B., Levine, S., & Thompson, R. F. (1989) · Science · doi:10.1126/science.2704997 · Cited by 458 · see citing works
Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.
Kim, J. J., Foy, M. R., & Thompson, R. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4750 · Cited by 435 · see citing works
Stress: metaplastic effects in the hippocampus
Kim, J. J., & Yoon, K. S. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01322-8 · Cited by 403 · see citing works
The organization of divergent axonal projections from the midbrain raphe nuclei in the rat
Imai, H., Steindler, D. A., & Kitai, S. T. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430307 · Cited by 369 · see citing works
Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders
McEwen, B. S., & Magarinos, A. M. (2001) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.266 · Cited by 349 · see citing works
Diamond, D. M., Fleshner, M., Ingersoll, N., & Rose, G. M. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.661 · Cited by 340 · see citing works
Köhler, C., & Steinbusch, H. W. M. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90054-9 · Cited by 330 · see citing works
Magariños, A. M., Deslandes, A., & McEwen, B. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00163-6 · Cited by 330 · see citing works
Depression, antidepressants, and the shrinking hippocampus
Sapolsky, R. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231475998 · Cited by 327 · see citing works
Activity of Serotonergic Neurons in Behaving Animals
Jacobs, B. L. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00012-3 · Cited by 318 · see citing works
Grahn, R. E., Will, M. J., Hammack, S. E., Maswood, S., McQueen, M. B., Watkins, L. R., & Maier, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01208-1 · Cited by 298 · see citing works
Bliss, T. V. P., Goddard, G. V., & Riives, M. L. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014507 · Cited by 293 · see citing works
Chaouloff, F. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00008-1 · Cited by 256 · see citing works
Xu, L., Hölscher, C., Anwyl, R., & Rowan, M. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.6.3204 · Cited by 248 · see citing works
Self-citationStaubli, U., & Xu, F.-B. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02445.1995 · Cited by 233 · see citing works
Kirby, L. G., Chou-Green, J. M., Davis, K., & Lucki, I. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00287-4 · Cited by 201 · see citing works
Corticosteroid Actions in the Hippocampus
Joëls, M. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00688.x · Cited by 196 · see citing works
de Kloet, E. R. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00552-5 · Cited by 194 · see citing works
Amat, J., Matus-Amat, P., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00368-0 · Cited by 158 · see citing works
Stewart, C. A., & Reid, I. (2000) · Psychopharmacology · doi:10.1007/s002130050045 · Cited by 152 · see citing works
Joseph, M. H., & Kennett, G. A. (1983) · Brain Research · doi:10.1016/0006-8993(83)90598-x · Cited by 151 · see citing works
Corradetti, R., Ballerini, L., Pugliese, A. M., & Pepeu, G. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90140-w · Cited by 141 · see citing works
Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain
Fattaccini, C., Bolaños, F. J., GOZLAN, H., & Hamon, M. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90076-4 · Cited by 131 · see citing works
Wilde, M. I., & Benfield, P. (1995) · Drugs · doi:10.2165/00003495-199549030-00007 · Cited by 128 · see citing works
Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors
Hervás, I., & Artigas, F. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00579-2 · Cited by 123 · see citing works
Vahabzadeh, A., & Fillenz, M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00619.x · Cited by 117 · see citing works
Matsumoto, M., Togashi, H., Mori, K., Ueno, K.-I., Ohashi, S., Kojima, T., & Yoshioka, M. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38802-0 · Cited by 104 · see citing works
How antidepressants work: New perspectives on the pathophysiology of depressive disorder
Reid, I., & Stewart, C. A. (2001) · The British Journal of Psychiatry · doi:10.1192/bjp.178.4.299 · Cited by 99 · see citing works
Staubli, U., & Otaky, N. (1994) · Brain Research · doi:10.1016/0006-8993(94)90003-5 · Cited by 98 · see citing works
Stress, hippocampal plasticity, and spatial learning
Garcia, R. (2001) · Synapse · doi:10.1002/syn.1040 · Cited by 97 · see citing works
Diamond, D. M., Catherine Bennett, M., Stevens, K. E., Wilson, R. L., & Rose, G. M. (1990) · Psychobiology · doi:10.3758/bf03327243 · Cited by 94 · see citing works
Orthodromic activation of hippocampal CA1 region of the rat
Leung, L.-W. S. (1979) · Brain Research · doi:10.1016/0006-8993(79)90869-2 · Cited by 74 · see citing works
Malagié, I., Deslandes, A., & Gardier, A. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00486-6 · Cited by 68 · see citing works
Park, S. P., Lopez-Rodriguez, F., Wilson, C. L., Maidment, N. T., Matsumoto, Y., & Engel, J. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01511-5 · Cited by 66 · see citing works
Levkovitz, Y. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00244-x · Cited by 64 · see citing works
von Frijtag, J. C., Kamal, A., Reijmers, L. G. J. E., Schrama, L. H., van den Bos, R., & Spruijt, B. M. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02062-6 · Cited by 62 · see citing works
Delbende, C., Bunel, D. T., Tarozzo, G., Grino, M., Oliver, C., Mocaër, E., & Vaudry, H. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90406-5 · Cited by 60 · see citing works
Available, N. A. N., & Available, N. A. N. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000381 · Cited by 57 · see citing works
The biochemistry of memory formation and its regulation by hormones and neuromodulators
Izquierdo, I., & Medina, J. (1997) · Psychobiology · doi:10.3758/bf03327022 · Cited by 53 · see citing works
Azmitia, E. C. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902030410 · Cited by 50 · see citing works
Matsuo, M., Kataoka, Y., Mataki, S., Kato, Y., & Oi, K. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12982-7 · Cited by 49 · see citing works
Passani, M. B., Pugliese, A. M., Azzurrini, M., & Corradetti, R. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13132.x · Cited by 49 · see citing works
Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour
Whitton, P. S., Sarna, G. S., Kp, D., & Curzon, G. (1991) · Psychopharmacology · doi:10.1007/bf02244558 · Cited by 47 · see citing works
Vollmayr, B., Keck, S., Henn, F. A., & Schloss, P. D. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01346-x · Cited by 44 · see citing works
Neurochemical and Pharmacological Properties of Tianeptine, A Novel Antidepressant
Labrid, C., Mocaër, E., & Kamoun, A. (1992) · The British Journal of Psychiatry · doi:10.1192/s0007125000296694 · Cited by 44 · see citing works
In vivo studies on the enhancement of serotonin reuptake by tianeptine
Simoni, M. G. D., Luigi, A. D., Clavenna, A., et al. (1992) · Brain Research · doi:10.1016/0006-8993(92)90804-i · Cited by 43 · see citing works
Activity of Serotonergic Neurons in Behaving Animals
Jacobs, B. L., & Fornal, C. A. (1999) · Neuropsychopharmacology · doi:10.1038/sj.npp.1395336 · Cited by 42 · see citing works
Acsády, L., Arabadzisz, D., Katona, I., et al. (1996) · PubMed · Cited by 41 · see citing works
Nowakowska, E., Kus, K., Chodera, A., et al. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300156 · Cited by 41 · see citing works
Effect of Aversive Stimulation on 5-Hydroxytryptamine and Dopamine Metabolism in the Rat Brain
Ge, J. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00024-5 · Cited by 40 · see citing works
Wilkinson, L. S., Humby, T., Killcross, S., Robbins, T. W., & Everitt, B. J. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01610.x · Cited by 40 · see citing works
Presynaptic serotonin mechanisms in rats subjected to inescapable shock
EDWARDS, E., Kornrich, W., Houtten, P. V., & Henn, F. A. (1992) · Neuropharmacology · doi:10.1016/0028-3908(92)90063-u · Cited by 37 · see citing works
Piñeyro, G., Deveault, L., Blier, P., Dennis, T., & de Montigny, C. (1995) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00169324 · Cited by 37 · see citing works
Opioid antagonist eliminates the stress-induced impairment of long-term potentiation (LTP)
Shors, T. J., Levine, S. D., & Thompson, R. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91270-q · Cited by 36 · see citing works
Broqua, P., Baudrie, V., Laude, D., & Chaouloff, F. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90232-o · Cited by 35 · see citing works
Mennini, T., Taddei, C., Codegoni, A., et al. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90211-y · Cited by 29 · see citing works
Dresse, A., & Scuvée-Moreau, J. (1988) · PubMed · Cited by 26 · see citing works
Healy, D. J., & Drugan, R. C. (1996) · Psychobiology · doi:10.3758/bf03331961 · Cited by 20 · see citing works
Sabol, K. E., Richards, J. B., & Seiden, L. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90509-8 · Cited by 17 · see citing works
Oluyomi, A. O., Datla, K. P., & Curzon, G. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00016-6 · Cited by 13 · see citing works
Matsuo, M. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)12982-7 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [71]71. Wilde M, Penfield P (1995) Tianeptine. A review of its pharmacody- namic and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression. Drugs 49:411-439.
Cited by
Sorted by citations
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works
Towards a glutamate hypothesis of depression
Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036 · see citing works
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 457 · see citing works
McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.80 · Cited by 406 · see citing works
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350 · see citing works
Regulation of hippocampal H3 histone methylation by acute and chronic stress
Hunter, R. G., McCarthy, K. J., Milne, T. A., Pfaff, D. W., & McEwen, B. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911143106 · Cited by 290 · see citing works
Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.018 · Cited by 281 · see citing works
Long-Term Plasticity of Visually Evoked Potentials in Humans is Altered in Major Depression
Normann, C., Schmitz, D., Fürmaier, A., Döing, C., & Bach, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.006 · Cited by 243 · see citing works
From Serotonin to Neuroplasticity: Evolvement of Theories for Major Depressive Disorder
Liu, B., Liu, J., Wang, M., Zhang, Y., & Li, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00305 · Cited by 249 · see citing works
Sairanen, M., O’Leary, O. F., Knuuttila, J. E., & Castrén, E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.069 · Cited by 206 · see citing works
Cellular and molecular mechanisms in the long-term action of antidepressants.
Racagni, G., & Popoli, M. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.4/gracagni · Cited by 192 · see citing works
Kole, M. H. P., Swan, L., & Fuchs, E. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02136.x · Cited by 181 · see citing works
Cui, M., Yang, Y., Yang, J., Zhang, J., Han, H., Ma, W., Li, H., Mao, R., Xu, L., Hao, W., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.048 · Cited by 153 · see citing works
Jay, T. M., Rocher, C., Hotte, M., Naudon, L., Gurden, H., & Spedding, M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033225 · Cited by 141 · see citing works
Tan, H., Zhong, P., & Yan, Z. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0143-04.2004 · Cited by 112 · see citing works
Establishing an Agenda for Translational Research on PTSD
MILLER, M. M., & McEWEN, B. S. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.023 · Cited by 101 · see citing works
Vouimba, R.-M., Muñoz, C., & Diamond, D. M. (2006) · Stress · doi:10.1080/10253890600610973 · Cited by 96 · see citing works
Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation
Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.06.023 · Cited by 65 · see citing works
Late-life depression is not associated with dementia-related pathology.
Wilson, R. S., Boyle, P. A., Capuano, A. W., Shah, R. C., Hoganson, G. M., Nag, S., & Bennett, D. A. (2016) · Neuropsychology · doi:10.1037/neu0000223 · Cited by 60 · see citing works
Normann, C., Frase, S., Haug, V., von Wolff, G., Clark, K., Münzer, P., Dorner, A., Scholliers, J., Horn, M., Vo Van, T., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.008 · Cited by 56 · see citing works
Bétry, C., Etiévant, A., Pehrson, A., Sánchez, C., & Haddjeri, N. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.12.002 · Cited by 59 · see citing works
Rubio, F. J., Ampuero, E., Sandoval, R., Toledo, J., Pancetti, F., & Wyneken, U. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00066 · Cited by 54 · see citing works
Dupin, N., Mailliet, F., Rocher, C., Kessal, K., Spedding, M., & Jay, T. M. (2006) · Neurotoxicity Research · doi:10.1007/bf03033356 · Cited by 37 · see citing works
Kanzari, A., Bourcier-Lucas, C., Freyssin, A., Abrous, D. N., Haddjeri, N., & Lucas, G. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.94 · Cited by 33 · see citing works
- Authors
- Shakesby, A. C., Anwyl, R., & Rowan, M. J.
- Affiliations
- Trinity College Dublin (IE)
- ORCID
- Rowan, Michael J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-05-01
- Volume
- 22
- Issue
- 9
- Pages
- 3638-3644
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6758347
- OpenAlex
- W2126689937
- Cited by
- 173
- References
- 75
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 13 · 2014: 10 · 2013: 8 · 2012: 4
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Health Research Board
- Enterprise Ireland
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- stress, synaptic plasticity, long-term potentiation, hippocampus, CA1, serotonin, tianeptine, fluoxetine, fenfluramine, antidepressants, inescapable stress, glutamatergic synapses, enantiomers
- MeSH terms
- Animals, Antidepressive Agents, Corticosterone, Drug Antagonism, Electrodes, Implanted, Exercise Test, Fenfluramine, Fluoxetine, Hippocampus, Male, Neuronal Plasticity, Serotonin, Stress, Physiological, Synapses, Thiazepines, Rats, Wistar, Selective Serotonin Reuptake Inhibitors, Long-Term Potentiation, Serotonin Agents, Excitatory Postsynaptic Potentials, Rats
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