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Efferent connections of the hypothalamic “aggression area” in the rat
Abstract
The efferent connections of the hypothalamic area of the rat, where attack behaviour can be elicited by electrical stimulation, were studied using iontophoretic injections of Phaseolus vulgaris-leucoagglutinin. Specificity for the hypothalamic "attack area" was investigated by comparison with efferents of hypothalamic sites outside the attack area. The hypothalamic attack area consists of the intermediate hypothalamic area and the ventrolateral pole of the ventromedial hypothalamic nucleus. Fibres from the hypothalamic attack area, as well as fibres from several other hypothalamic sites, form diffuse fibre "streams" running rostrally or caudally. Many varicosities that are found on the fibres suggest, that these fibres are capable of influencing many brain sites along their way. Projection sites were found throughout the brain. In the comparison between attack area efferents and controls, many overlapping brain sites were found. Hypothalamic efferents preferentially originating in the largest part of the attack area, i.e. the intermediate hypothalamic area, were found in the mediodorsal and parataenial thalamic nuclei. Within the septum, a spatial organization of hypothalamic innervation was found. Fibres from the attack area formed specialized "pericellular baskets" in the dorsolateral aspect of the intermediate part of the lateral septal nucleus. Fibres from other hypothalamic sites were found in other septal areas and did not form these septal baskets. Within the mesencephalic central gray, fibres from the attack area were found specifically in the dorsal part and dorsal aspect of the lateral part of the central gray. Physiological and pharmacological studies have shown that several brain sites are involved in different aspects of aggressive behaviour. Some of these areas, as for instance the dorsomedial thalamic nucleus, septum and central gray, are innervated by efferents from the hypothalamic attack area, whereas other sites, like ventral premammillary nucleus and ventral tegmental area, are not. It is concluded from the present findings, that a number of brain sites, that are known to be involved in agonistic behaviour, receive hypothalamic information preferentially from the hypothalamic attack area through diffusely arranged varicose fibres. The function of each connection in the regulation of specific behaviours remains to be further investigated.
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“In rats, a hypothalamic “aggression area” (HAA) has been implicated in aggressive behavior by stimulation paradigms, and efferents from this region have been mapped, with substantial connection throughout the brain, including thalamic nuclei, septal nuclei, and the periaqueductal gray (Roeling et al., 1994).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Roeling et al., 1994
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Metadata
- Authors
- Roeling, T. A. P., Veening, J. G., Kruk, M. R., Peters, J. P. W., Vermelis, M. E. J., & Nieuwenhuys, R.
- Affiliations
- Radboud University Nijmegen (NL)
- Leiden University (NL)
- Corresponding author
- Roeling, T.A.P.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 59
- Issue
- 4
- Pages
- 1001-1024
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2034313355
- Cited by
- 126
- References
- 76
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 4
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- efferent projections, aggression, ventromedial hypothalamus, lateral septal nucleus, mediodorsal thalamus, periaqueductal gray, agonistic behavior, rats
- MeSH terms
- Agonistic Behavior, Animals, Brain Mapping, Brain Stem, Efferent Pathways, Electric Stimulation, Grooming, Hypothalamus, Male, Periaqueductal Gray, Septal Nuclei, Serotonin, Thalamic Nuclei, Ventromedial Hypothalamic Nucleus, Rats, Wistar, Rats
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