Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography

Tribollet, E.; Barberis, C.; Jard, S.; Dubois-Dauphin, M.; Dreifuss, J.J.

doi:10.1016/0006-8993(88)91437-0

Cited by 442Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research

Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography

Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., Dreifuss, J.J.·1988·Brain Research

DOI 10.1016/0006-8993(88)91437-0

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Abstract

Sites which bind tritiated vasopressin (AVP) with high affinity were detected in the brain of male, adult rats, by light microscopic autoradiography. Their anatomical localization differed markedly from that of high affinity binding sites for tritiated oxytocin (OT) determined in the same animal. Co-labelling was minimized by using low concentrations of [3H]AVP and [3H]OT. Binding of the former occurred predominantly in several structures of the limbic system (septum, amygdala, bed nucleus of the stria terminalis, accumbens nucleus), in two hypothalamic nuclei (suprachiasmatic and dorsal tuber) and in the area of the nucleus of the solitary tract. Binding of OT was evidenced in the olfactory tubercle, the ventromedial hypothalamic nucleus, the central amygdaloid nucleus and the ventral hippocampus. The ligand specificity of the binding sites was assessed in competition experiments. Synthetic structural analogues were used, allowing to discriminate OT receptors (OH[Thr4,Gly7]OT) from V2 receptors (dDAVP and d[Tyr(Me)2]VDAVP), V1 receptors ([Phe2,Orn8]VT) and V1b receptors (desGly9d(CH2)5AVP). Our main conclusions are, firstly, that AVP and OT binding sites can be readily distinguished, and that there is virtually no overlap in their distribution in the rat brain. Second, we showed that the sites which bind AVP with high affinity in the brain are V1 receptors, different both from the renal V2 receptors and from the anterior pituitary V1b receptors. Our results support the conjecture that AVP and OT play a role in interneuronal communication in the brain.

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The effects of ICV injections on social play reflect a net inhibition of V1aR activation in multiple brain regions.
“Instead, the widespread distribution of V1aR throughout the brain, including many areas that border the ventricles (Tribollet et al., 1988), suggests that the effects of ICV injections on social play reflect a net inhibition of V1aR activation in multiple brain regions.”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Tribollet et al., 1988
Distinct and non-overlapping receptor distribution profiles in rats were already reported by Tribollet et al (1988) and Veinante and Freund-Mercier (1997).
“Notably, distinct and non-overlapping receptor distribution profiles in rats were already reported by Tribollet et al (1988), and Veinante and Freund-Mercier (1997).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Tribollet et al (1988)

The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,159 · see citing works
Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
Poulain, D. A., & Wakerley, J. B. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90044-6 · Cited by 813 · see citing works
The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum
de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524 · see citing works
Hormonal Stimulation of Phosphatidylinositol Breakdown, with Particular Reference to the Hepatic Effects of Vasopressin
Michell, R. H., Kirk, C. J., & BILLAH, M. M. (1979) · Biochemical Society Transactions · doi:10.1042/bst0070861 · Cited by 440 · see citing works
Vasopressin antagonists allow demonstration of a novel type of vasopressin receptor in the rat adenohypophysis.
Jard, S., Gaillard, R. C., Guillon, G., Marie, J., Schoenenberg, P., Muller, A. F., Manning, M., & Sawyer, W. H. (1986) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10336-2 · Cited by 276 · see citing works
Self-citation
Vasopressin : principles and properties
Gash, D. M., & Boer, G. J. (1987) · Plenum Press eBooks · Cited by 250 · see citing works
Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli
Bone, E. A., Fretten, P., Palmer, S., Kirk, C. J., & Michell, R. H. (1984) · Biochemical Journal · doi:10.1042/bj2210803 · Cited by 221 · see citing works
Pharmacological characteristics and anatomical distribution of [3H]oxytocin-binding sites in the wistar rat brain studied by autoradiography
Freund-Mercier, M. J., Stoeckel, M. E., Palacios, J. M., Pazos, A., Reichhart, J. M., Porte, A., & Richard, P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90113-8 · Cited by 192 · see citing works
Vasopressin and oxytocin—their role in neurotransmission
Buijs, R. M. (1983) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(83)90056-6 · Cited by 189 · see citing works
(3H)-Vasopressin Binding to Isolated Rat Hepatocytes and Liver Membranes: Regulation by GTP and Relation to Glycogen Phosphorylase Activation
Cantau, B., Keppens, S., WULF, H. D., & Jard, S. (1980) · Journal of Receptor Research · doi:10.3109/10799898009044096 · Cited by 164 · see citing works
Self-citation
Topography of binding sites for neurohypophyseal hormones in rat brain
de Kloet, E. R., Rotteveel, F. T. M., Voorhuis, T. A. M., & Terlou, M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90036-6 · Cited by 161 · see citing works
Pharmacological characterization of two specific binding sites for neurohypophyseal hormones in hippocampal synaptic plasma membranes of the rat.
Audigier, S., & Barberis, C. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03794.x · Cited by 156 · see citing works
Self-citation
Vasopressin Isoreceptors in Mammals: Relation to Cyclic AMP-Dependent and Cyclic AMP-Independent Transduction Mechanisms
Jard, S. (1983) · Current topics in membranes and transport · doi:10.1016/s0070-2161(08)60533-x · Cited by 145 · see citing works
Self-citation
Excitation of neurones in the rat paraventricular nucleus in vitro by vasopressin and oxytocin.
Inenaga, K., & Yamashita, H. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp015928 · Cited by 138 · see citing works
The globus pallidus and its rostroventral extension into the olfactory tubercle of the rat: A cyto- and chemoarchitectural study
Switzer, R. C., Hill, J., & Heimer, L. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90005-7 · Cited by 131 · see citing works
Structural Requirements for Activation of Vasopressin-sensitive Adenylate Cyclase, Hormone Binding, and Antidiuretic Actions: Effects of Highly Potent Analogues and Competitive Inhibitors
Butlen, D., Guillon, G., Rajerison, R. M., Jard, S., Sawyer, W. H., & Manning, M. (1978) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13565-7 · Cited by 122 · see citing works
Self-citation
Arginine-vasopressin binding sites in rat brain: A quantitative autoradiographic study
Biegon, A. R., Terlou, M., Voorhuis, T. D., & de Kloet, E. R. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90027-2 · Cited by 119 · see citing works
Neurotransmitter actions in the vertebrate nervous system
COYLE, J. T. (1986) · Cell · doi:10.1016/0092-8674(86)90551-9 · Cited by 103 · see citing works
Design and uses of selective agonistic and antagonistic analogs of the neuropeptides oxytocin and vasopressin
Manning, M., & Sawyer, W. H. (1984) · Trends in Neurosciences · doi:10.1016/s0166-2236(84)80179-4 · Cited by 95 · see citing works
Light microscopic autoradiographic localization of [3H]arginine-vasopressin binding sites in the rat brain and kidney
van Leeuwen, F. W., & Wolters, P. S. (1983) · Neuroscience Letters · doi:10.1016/0304-3940(83)90223-9 · Cited by 84 · see citing works
Neurons in the dorsal motor nucleus of the vagus nerve are excited by oxytocin in the rat but not in the guinea pig.
Raggenbass, M., Dubois‐Dauphin, M., Charpak, S., & Dreifuss, J. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3926 · Cited by 79 · see citing works
Self-citation
Localization and characterization of vasopressin-binding sites in the amygdala of the rat brain
Dorsa, D. M., Petracca, F. M., Baskin, D., & Cornett, L. E. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-07-01764.1984 · Cited by 66 · see citing works
Properties of rat anterior pituitary vasopressin receptors: relation to adenylate cyclase and the effect of corticotropin-releasing factor.
Gaillard, R.-C., Schoenenberg, P., Favrod-Coune, C. A., Muller, A. F., Marie, J., Bockaert, J., & Jard, S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.9.2907 · Cited by 64 · see citing works
Self-citation
Kinetic and pharmacological characterization of vasopressin membrane receptors from human kidney medulla: Relation to adenylate cyclase activation
Guillon, G., Butlen, D., Cantau, B., Barth, T., & Jard, S. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90216-3 · Cited by 63 · see citing works
Self-citation
[3H]Vasopressin binding to rat hippocampal synaptic plasma membrane
Barberis, C. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80795-9 · Cited by 53 · see citing works
Self-citation
Biochemical and electrophysiological evidence of functional vasopressin receptors in the rat superior cervical ganglion.
Kiraly, M., Audigier, S., Tribollet, E., Barberis, C., Dolivo, M., & Dreifuss, J.-J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5335 · Cited by 50 · see citing works
Self-citation
Vasopressin Receptors in the Brain and Pituitary
van Leeuwen, F. W. (1987) · Springer eBooks · doi:10.1007/978-1-4615-8129-1_12 · Cited by 44 · see citing works
Vasopressin affects adenylate cyclase activity in rat brain: A possible neuromodulator
COURTNEY, N., & Raskind, M. A. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90203-5 · Cited by 37 · see citing works
Vasopressin receptor subtypes in dorsal hindbrain and renal medulla
Cornett, L. E., & Dorsa, D. M. (1985) · Peptides · doi:10.1016/0196-9781(85)90081-6 · Cited by 22 · see citing works
Oxytocin and Vasopressin
Mühlethaler, M., Raggenbass, M., & Dreifuss, J.-J. (1985) · Springer eBooks · doi:10.1007/978-1-4684-4961-7_15 · Cited by 19 · see citing works
Self-citation
Comparison of the effects of muscarine and vasopressin on inositol phospholipid metabolism in the superior cervical ganglion of the rat.
Horwitz, J., Anderson, C. H., & Perlman, R. L. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24983-7 · Cited by 19 · see citing works
Distribution of neurophysin II immunoreactive nerve fibers within the subnuclei of the nucleus of the tractus solitarius of the rat
Kalia, M., Fuxé, K., Hökfelt, T. G. M., Härfstrand, A., Lang, R. E., & Ganten, D. (1984) · Brain Research · doi:10.1016/0006-8993(84)90682-6 · Cited by 17 · see citing works
V1-Vasopressin Receptors in the Septum of the Rat Brain. Electrophysiological Evidence
Raggenbass, M., Tribollet, E., & Dreifuss, J. J. (1988) · Journal of Receptor Research · doi:10.3109/10799898809048991 · Cited by 1 · see citing works
Self-citation

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Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833 · see citing works
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740 · see citing works
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
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Insel, T., Wang, Z., & Ferris, C. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05381.1994 · Cited by 454 · see citing works
The hypothalamic-neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: an old concept revisited
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450 · see citing works
Naturally Occurring Differences in Maternal Care are Associated with the Expression of Oxytocin and Vasopressin (V1a) Receptors: Gender Differences
Francis, D. D., Young, L. J., Meaney, M. J., & Insel, T. R. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.0007-1331.2002.00776.x · Cited by 415 · see citing works
Oxytocin and sexual behavior
Carter, C. S. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80176-9 · Cited by 417 · see citing works
Oxytocin Attenuates Stress-Induced c-fosmRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity
Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408 · see citing works
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Lukas, M., Toth, I., Reber, S. O., Slattery, D. A., Veenema, A. H., & Neumann, I. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.95 · Cited by 403 · see citing works
Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
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Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353 · see citing works
Oxytocin enhances social recognition by modulating cortical control of early olfactory processing
Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.033 · Cited by 359 · see citing works
Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
Xiao, L., Priest, M. F., Nasenbeny, J., Lu, T., & Kozorovitskiy, Y. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.003 · Cited by 292 · see citing works
125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand
Elands, J., Barberis, C., Jard, S., Tribollet, E., Dreifuss, J.-J., Bankowski, K., Manning, M., & Sawyer, W. H. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90778-9 · Cited by 245 · see citing works
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Tribollet, E., Charpak, S., Schmidt, A., Dubois-Dauphin, M., & Dreifuss, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01764.1989 · Cited by 228 · see citing works
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Young, L. J. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1548 · Cited by 211 · see citing works
Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman, J. F. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950100030003 · Cited by 209 · see citing works
A neural switch for active and passive fear
Gozzi, A., Jain, A., Giovanelli, A., Bertollini, C., Crestan, V., Schwarz, A. J., Tsetsenis, T., Ragozzino, D., Gross, C. T., & Bifone, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.008 · Cited by 209 · see citing works
Gonadal steroids regulate oxytocin receptors but not vasopressin receptors in the brain of male and female rats. An autoradiographical study
Tribollet, E., Audigier, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90232-z · Cited by 203 · see citing works
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L. Kovács, G., Sarnyai, Z., & Szabó, G. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00064-x · Cited by 195 · see citing works
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works
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Oxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimulia
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172 · see citing works
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Background
Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
Yoshimura, R., Kiyama, H., Kimura, T., Araki, T., Maeno, H., Tanizawa, O., & Tohyama, M. (1993) · Endocrinology · doi:10.1210/endo.133.3.8396014 · Cited by 161 · see citing works
Baroreflex control of heart rate by oxytocin in the solitary-vagal complex
Higa, K. T., Mori, E., Viana, F. F., Morris, M., & Michelini, L. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2000 · Cited by 157 · see citing works
Oxytocin Receptors in the Central Nervous System: Distribution, Development, and Species Differencesa
TRIBOLLET, E., DUBOIS‐DAUPHIN, M., DREIFUSS, J. J., BARBERIS, C., & JARD, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34343.x · Cited by 156 · see citing works
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Young, Toloczko, & Insel (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00332.x · Cited by 139 · see citing works
Localization of oxytocin binding sites in the human brainstem and upper spinal cord: an autoradiographic study
Loup, F., Tribollet, E., Dubois-Dauphin, M., Pizzolato, G., & Dreifuss, J. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90317-x · Cited by 136 · see citing works
Self-citation
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PHILLIPS, P. A., ABRAHAMS, J. M., KELLY, J. M., MOOSER, V., TRINDER, D., & JOHNSTON, C. I. (1990) · Endocrinology · doi:10.1210/endo-126-3-1478 · Cited by 127 · see citing works
Efferent connections of the hypothalamic “aggression area” in the rat
Roeling, T. A. P., Veening, J. G., Kruk, M. R., Peters, J. P. W., Vermelis, M. E. J., & Nieuwenhuys, R. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90302-6 · Cited by 126 · see citing works
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McCann, M. J., & Rogers, R. C. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018202 · Cited by 118 · see citing works
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Lee, S.-Y., Park, S.-H., Chung, C., Kim, J. J., Choi, S.-Y., & Han, J.-S. (2015) · Scientific Reports · doi:10.1038/srep18540 · Cited by 119 · see citing works
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LOLAIT, S. J., O'CARROLL, A., & BROWNSTEIN, M. J. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44688.x · Cited by 87 · see citing works
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Xiao, L., Priest, M. F., & Kozorovitskiy, Y. (2018) · eLife · doi:10.7554/elife.33892 · Cited by 83 · see citing works
“In addition to OxtR, oxytocin has been shown to bind structurally related vasopressin receptors (Gimpl and Fahrenholz, 2001; Tribollet et al., 1988).”
Background
Vasopressin in the brain of the golden hamster: The distribution of vasopressin binding sites and of immunoreactivity to the vasopressin‐related glycopeptide
Dubois‐Dauphin, M., Pevet, P., Triboilet, E., & Dreif'Uss, J. J. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903000408 · Cited by 85 · see citing works
Self-citation
Vasopressin in the forebrain of common marmosets (Callithrix jacchus): studies with in situ hybridization, immunocytochemistry and receptor autoradiography
Wang, Z., Toloczko, D., Young, L. J., Moody, K., Newman, J. D., & Insel, T. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00636-7 · Cited by 75 · see citing works
Functional magnetic resonance imaging and the neurobiology of vasopressin and oxytocin
FERRIS, C. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00425-1 · Cited by 75 · see citing works
Quantitative mapping reveals age and sex differences in vasopressin, but not oxytocin, immunoreactivity in the rat social behavior neural network
DiBenedictis, B. T., Nussbaum, E. R., Cheung, H. K., & Veenema, A. H. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24216 · Cited by 74 · see citing works
Regulation of oxytocin receptor messenger ribonucleic acid in the ventromedial hypothalamus by testosterone and its metabolites
Bale, T. L., & Dorsa, D. M. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588251 · Cited by 65 · see citing works
The Formation and Function of the VTA Dopamine System
Hou, G., Hao, M., Duan, J., & Han, M.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073875 · Cited by 65 · see citing works
Oxytocin and rodent sociosexual responses: from behavior to gene expression
M.Witt, D. (1995) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00006-z · Cited by 64 · see citing works
Lasting adaptations in social behavior produced by social disruption and inhibition of adult neurogenesis
Opendak, M., Offit, L., Monari, P., Schoenfeld, T. J., Sonti, A. N., Cameron, H. A., & Gould, E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4435-15.2016 · Cited by 61 · see citing works
Vasopressin receptors in the mouse (Mus musculus) brain: sex-related expression in the medial preoptic area and hypothalamus
Dubois-Dauphin, M., Barberis, C., & de Bilbao, F. (1996) · Brain Research · doi:10.1016/s0006-8993(96)01019-0 · Cited by 57 · see citing works
Self-citation
Comparing vasopressin and oxytocin fiber and receptor density patterns in the social behavior neural network: implications for cross-system signaling
Smith, C. J. W., DiBenedictis, B. T., & Veenema, A. H. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.001 · Cited by 59 · see citing works
Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats
Griffin, G. D., Ferri‐Kolwicz, S. L., Reyes, B. A. S., Van Bockstaele, E. J., & Flanagan‐Cato, L. M. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22470 · Cited by 56 · see citing works
Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC
Li, Q., Zhang, B., Cao, H., Liu, W., Guo, F., Shen, F., Ye, B., Liu, H., Li, Y., & Liu, Z. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107836 · Cited by 47 · see citing works
Vasopressin infusion into the lateral septum of adult male rats rescues progesterone-induced impairment in social recognition
Bychowski, M. E., Mena, J. D., & Auger, C. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.047 · Cited by 37 · see citing works
Biological characterization of rodent and human vasopressin V1breceptors using SSR-149415, a nonpeptide V1breceptor ligand
Gal, C. S.-L., Raufaste, D., Derick, S., Blankenstein, J., Allen, J., Pouzet, B., Pascal, M., Wagnon, J., & Ventura, M. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00062.2007 · Cited by 35 · see citing works
Postweaning, forebrain-specific perturbation of the oxytocin system impairs fear conditioning
Pagani, J. H., Lee, H.-J., & Young, W. S. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2011.00709.x · Cited by 30 · see citing works
Untitled work
McEwen (2004) · doi:10.1016/s1054-3589(04)50016-9 · Cited by 22 · see citing works
Oxytocin, vasopressin and their interplay with gonadal steroids
Dhakar, M. B., Stevenson, E. L., & Caldwell, H. K. (2013) · Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior · doi:10.1017/cbo9781139017855.003 · Cited by 20 · see citing works
Congenital vasopressin deficiency and acute and chronic opiate effects on hypothalamo-pituitary-adrenal axis activity in Brattleboro rats
Domokos, Á., Mergl, Z., Barna, I., Makara, G. B., & Zelena, D. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0356 · Cited by 19 · see citing works

Authors: Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J.
Affiliations: Centre National de la Recherche Scientifique (FR)
University of Geneva (CH)
Corresponding author: Tribollet, E.
Venue: Brain Research
Publisher: Elsevier BV
Published: 1988-02
Volume: 442
Issue: 1
Pages: 105-118
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/0006-8993(88)91437-0
OpenAlex: W1981333355
Cited by: 442
References: 35
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 10 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 7 · 2014: 11 · 2013: 6 · 2012: 4
FWCI: 56.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: vasopressin receptor, oxytocin receptor, high-affinity binding sites, V1 receptor, V2 receptor, V1b receptor, receptor localization, limbic system, hypothalamus, nucleus tractus solitarius, olfactory tubercle, central amygdala, ventral hippocampus, receptor specificity, competitive binding, interneuronal communication, rat brain
MeSH terms: Animals, Arginine Vasopressin, Autoradiography, Binding Sites, Brain, Hypothalamus, Limbic System, Male, Oxytocin, Rats, Inbred Strains, Receptors, Angiotensin, Thalamus, Receptors, Vasopressin, Receptors, Oxytocin, Rats

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Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography

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