Maternal communication of circadian phase to the developing mammal

Reppert, S

doi:10.1016/0306-4530(88)90007-8

Cited by 53Circadian rhythm and melatoninHypothalamic control of reproductive hormonesSleep and Wakefulness Research

Maternal communication of circadian phase to the developing mammal

Reppert, S·1988·Psychoneuroendocrinology

DOI 10.1016/0306-4530(88)90007-8

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Abstract

In rodents, an entrainable circadian clock begins oscillating prenatally in the hypothalamic suprachiasmatic nuclei (SCN). The maternal circadian system coordinates (entrains) the timing of the developing clock to the prevailing light-dark cycle during both late fetal and early neonatal life. This maternal communication of circadian phase ensures that the developing animal is coordinated to the outside world until maturation of the normal pathway of light-dark entrainment in adults, the retinohypothalamic pathway, permits direct photic entrainment through the neonatal eye. The mechanism of maternal communication of circadian phase remains to be determined, but the necessity of the maternal SCN in this communication has been demonstrated. Indirect lines of evidence suggest that a similar scheme occurs for the development of circadian rhythms in humans.

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In humans, melatonin and dopamine receptors appear as early as gestational week 18 in the fetal SCN, suggesting melatonin and dopamine may serve as the primary communicators of circadian information for the fetus.
“In humans, melatonin and dopamine receptors appear as early as gestational week 18 in the fetal SCN26–28, suggesting melatonin and dopamine may serve as the primary communicators of circadian information for the fetus29,30.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [28]

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Authors: Reppert, S.
Affiliations: Massachusetts General Hospital (US)
Corresponding author: Reppert, S
ORCID: Reppert, S
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 1988
Volume: 13
Issue: 1-2
Pages: 63-78
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/0306-4530(88)90007-8
OpenAlex: W2069425055
Cited by: 53
References: 65
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 2
FWCI: 0.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-14427)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: suprachiasmatic nucleus, light-dark cycle, retinohypothalamic pathway, light entrainment, fetal development, rodents
MeSH terms: Animals, Animal Communication, Circadian Rhythm, Female, Maternal Behavior, Suprachiasmatic Nucleus, Rats

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Maternal communication of circadian phase to the developing mammal

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