Cited by 50Regulation of Appetite and ObesityStress Responses and CortisolNeuroendocrine regulation and behavior

The psychoneuroendocrinology of diabetes mellitus in rodents

Leedom, Liane J., Meehan, Woerner P.·1989·Psychoneuroendocrinology

Abstract

The metabolic-endocrine state of diabetes mellitus affects the brain and behavior of diabetic animals. Feeding, paradoxical sleep, analgesia, submissive behavior, and avoidance behavior, are generally increased in diabetic compared with nondiabetic rodents. In contrast, sexual behavior, aggressive behavior and sensitivity to the behavioral effects of amphetamine are decreased in diabetic rodents. This review examines behavioral changes in diabetes mellitus within the context of known disease-linked alterations in hypothalamo-pituitary relationships and brain monoamine metabolism.

Integrity signals

Registry

Crossref · 10.1016/0306-4530(89)90030-9

Cites

127 of 127 references verified0 citation errors · 0 not checkable

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  • Uncontrolled insulin-deficient diabetes is characterized by hyperglycemia and hyperphagia, progressive loss of body fat stores, and dramatic reduction of circulating leptin and insulin.

    “uDM is characterized by both hyperglycemia and hyperphagia (102), with progressive loss of body fat stores, and with a dramatic reduction of circulating levels of leptin as well as insulin (78).”

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Authors
Leedom, L. J., & Meehan, W. P.
Affiliations
  • Harbor–UCLA Medical Center (US)
  • University of Southern California (US)
Corresponding author
Leedom, Liane J.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
1989-01
Volume
14
Issue
4
Pages
275-294
ISSN
0306-4530 (ISSN-L)
OpenAlex
W1976239014
Cited by
50
References
127
Citations by year
2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 2 · 2012: 3
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
diabetes mellitus, rodent behavior, feeding behavior, REM sleep, analgesia, submissiveness, avoidance behavior, sexual behavior, aggression, amphetamine sensitivity, hypothalamic-pituitary axis, brain monoamine metabolism
MeSH terms
Animals, Behavior, Animal, Brain, Diabetes Mellitus, Experimental, Female, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Rodent Diseases, Rodentia, Mice, Rats

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