The psychoneuroendocrinology of diabetes mellitus in rodents
Abstract
The metabolic-endocrine state of diabetes mellitus affects the brain and behavior of diabetic animals. Feeding, paradoxical sleep, analgesia, submissive behavior, and avoidance behavior, are generally increased in diabetic compared with nondiabetic rodents. In contrast, sexual behavior, aggressive behavior and sensitivity to the behavioral effects of amphetamine are decreased in diabetic rodents. This review examines behavioral changes in diabetes mellitus within the context of known disease-linked alterations in hypothalamo-pituitary relationships and brain monoamine metabolism.
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Uncontrolled insulin-deficient diabetes is characterized by hyperglycemia and hyperphagia, progressive loss of body fat stores, and dramatic reduction of circulating leptin and insulin.
“uDM is characterized by both hyperglycemia and hyperphagia (102), with progressive loss of body fat stores, and with a dramatic reduction of circulating levels of leptin as well as insulin (78).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [102]
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Central nervous system control of food intake
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Leptin and the Central Nervous System Control of Glucose Metabolism
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“hyperphagia (102), with progressive loss of body fat”
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- Authors
- Leedom, L. J., & Meehan, W. P.
- Affiliations
- Harbor–UCLA Medical Center (US)
- University of Southern California (US)
- Corresponding author
- Leedom, Liane J.
- ORCID
- Leedom, Liane J.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 14
- Issue
- 4
- Pages
- 275-294
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W1976239014
- Cited by
- 50
- References
- 127
- Citations by year
- 2023: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 2 · 2012: 3
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- diabetes mellitus, rodent behavior, feeding behavior, REM sleep, analgesia, submissiveness, avoidance behavior, sexual behavior, aggression, amphetamine sensitivity, hypothalamic-pituitary axis, brain monoamine metabolism
- MeSH terms
- Animals, Behavior, Animal, Brain, Diabetes Mellitus, Experimental, Female, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Rodent Diseases, Rodentia, Mice, Rats
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