Variability in subjective responses to cocaine: initial experiences of college students
Abstract
Eighty psychology students were administered a short self-report questionnaire that probed their initial and most recent experiences with cocaine. Most of the subjects were relatively inexperienced with cocaine; only five had used the drug more than 40 times. Measures of Global Positive and Global Negative responses to cocaine use were obtained. There was substantial variability in the response to cocaine on both the positive and negative effects scales, although there was no relationship between the magnitude of these self-reported effects of cocaine. The initial Global Positive (but not Global Negative) scores were correlated with latency to next use of cocaine and with lifetime use of the drug, suggesting that abuse potential of the drug is related to magnitude of initial positive effect. These data suggest that studies on predisposing factors in cocaine abuse should examine the basis for the variability in initial response to cocaine.
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Low D2 receptor binding may confer vulnerability to addiction, insofar as pleasurable experience with a drug is a potential risk for addiction.
“Insofar as pleasurable experience with a drug is a potential risk for addiction (Davidson et al., 1993; Volkow et al., 2002a), these results suggest that low D2 receptor binding may confer vulnerability.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Davidson et al., 1993
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- Authors
- Davidson, E. S., Finch, J. F., & Schenk, S.
- Affiliations
- Texas A&M University (US)
- Corresponding author
- Davidson, Emily S.
- ORCID
- Schenk, Susan
- Venue
- Addictive Behaviors
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 18
- Issue
- 4
- Pages
- 445-453
- ISSN
- 0306-4603 (ISSN-L)
- OpenAlex
- W2009696712
- Cited by
- 86
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 2
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Addictive Behaviors (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Demography › Youth, Drugs, and Violence
- Keywords
- cocaine, subjective effects, individual differences, positive and negative effects, university students, drug use experience, abuse liability, predisposing factors, self-report questionnaire
- MeSH terms
- Adolescent, Adult, Arousal, Cocaine, Euphoria, Female, Humans, Male, Motivation, Risk Factors, Substance-Related Disorders
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