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Cited by 120Olfactory and Sensory Function StudiesMultisensory perception and integrationBiochemical Analysis and Sensing Techniques

Anatomical evidence for convergence of olfactory, gustatory, and visceral afferent pathways in mouse cerebral cortex

Shipley, Michael T., Geinisman, Yuri·1984·Brain Research Bulletin
DOI 10.1016/0361-9230(84)90049-2
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Abstract

Flavor perception requires the neural integration of olfactory, gustatory and, possibly, visceral afferent information. Presently, it is not known where, or how this integration takes place in the brain. Neuroanatomical data presented here suggest that pathways subserving these sensory modalities converge in mouse insular cortex after surprisingly few synaptic relays. Orthograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to label main olfactory bulb (MOB) efferents. A projection into layer I of insular cortex was present in every case. Bulb transections were made to provoke anterograde degeneration and EM analysis confirmed that the olfactory projection to insular cortex was a terminal pathway. WGA-HRP injections in the MOB-recipient zone of insular cortex resulted in ortho and retrograde labeling of ascending and descending gustatory-visceral afferent pathways. It is concluded that in the mouse, there is a remarkably direct convergence of olfactory and gustatory-visceral sensory pathways in insular cortex. Together with the descending connections from insular cortex to the amygdala and to brainstem autonomic structures, it is possible that the cortical integration of olfactory and gustatory-visceral information could modulate mechanisms involved in food selection and autonomic reactions relating to the chemical senses. Basic mechanisms subserving flavor perception might be usefully modelled in mouse insular cortex.

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Crossref · 10.1016/0361-9230(84)90049-2

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  • The gustatory and visceral pathway involves GU/VISC cortical areas and VPMpc/VPLpc nuclei.

    “The gustatory and visceral pathway (involving GU/VISC cortical areas and VPMpc/VPLpc nuclei)55,108”

    From A mesoscale connectome of the mouse brain (2014) · cites this paper as [108]

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Authors
Shipley, M. T., & Geinisman, Y.
Affiliations
  • University of Cincinnati (US)
  • Northwestern University (US)
ORCID
Shipley, Michael T.
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
1984-03
Volume
12
Issue
3
Pages
221-226
ISSN
0361-9230 (ISSN-L)
DOI
10.1016/0361-9230(84)90049-2
OpenAlex
W1989087672
Cited by
120
References
40
Citations by year
2026: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
5.42
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
insula, olfactory pathway, gustatory pathway, visceral afferent pathways, flavor perception, mice, amygdala, food choice
MeSH terms
Afferent Pathways, Animals, Brain Mapping, Cerebral Cortex, Male, Mice, Inbred BALB C, Olfactory Bulb, Olfactory Pathways, Taste, Mice

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