Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain
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Under typical physiological conditions, tyrosine hydroxylase, the enzyme that converts tyrosine to L-DOPA, is about 75% saturated with tyrosine.
“Tyrosine hydroxylase, the enzyme involved in the conversion from tyrosine to L-DOPA, is about 75% saturated with tyrosine under typical physiological conditions (Carlsson and Lindqvist, 1978).”
From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Carlsson and Lindqvist, 1978
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- Authors
- Carlsson, A., & Lindqvist, M.
- Affiliations
- University of Gothenburg (SE)
- ORCID
- Carlsson, A.
- Venue
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Published
- 1978-06
- Volume
- 303
- Issue
- 2
- Pages
- 157-164
- ISSN
- 0028-1298 (ISSN-L)
- 1432-1912
- OpenAlex
- W2040456819
- Cited by
- 326
- References
- 15
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Naunyn-Schmiedeberg s Archives of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- dopamine synthesis, tryptophan hydroxylase, tyrosine hydroxylase, tryptophan, tyrosine, large neutral amino acids, enzyme kinetics, substrate saturation, brain regions, rat brain
- MeSH terms
- Amino Acids, Animals, Brain, Catecholamines, Dihydroxyphenylalanine, Haloperidol, 5-Hydroxytryptophan, Isoleucine, Kinetics, Male, Phenylalanine, Serotonin, Tryptophan, Tyrosine, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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