Differential effects on locomotor activity of injections of procaine into mediodorsal thalamus and pedunculopontine nucleus
Abstract
A comparison was made of the contributions to locomotor activity of output projections of the subpallidal region to the mediodorsal thalamus (MD) and to the pedunculopontine nucleus (PPN). Locomotor activity elicited by injections of picrotoxin into the subpallidal region was reduced by the administration of procaine to the pedunculopontine nucleus but not by the administration of procaine to mediodorsal thalamus. Since the pedunculopontine nucleus is part of the mesencephalic locomotor region (MLR) it appears that subpallido-pedunculopontine projections contribute to the locomotor component of adaptive behaviors associated with limbic integrative activities.
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Microinjections of the local anesthesia procaine into the midbrain extrapyramidal area, but not the medial mediodorsal thalamic nucleus, attenuate heightened locomotion induced by picrotoxin injections into the ventral pallidum.
“However, microinjections of the local anesthesia procaine into the midbrain extrapyramidal area, but not the medial mediodorsal thalamic nucleus, attenuate heightened locomotion induced by picrotoxin injections into the ventral pallidum (Mogenson and Wu, 1988).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Mogenson and Wu, 1988
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Self-citationSwerdlow, N. R., & Koob, G. F. (1987) · Brain Research · doi:10.1016/0006-8993(87)91129-2 · Cited by 208 · see citing works
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Self-citationA study of the contribution of hippocampal—accumbens—subpallidal projections to locomotor activity
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Self-citationEvidence that an accumbens to subpallidal GABAergic projection contributes to locomotor activity
Mogenson, G. J., & Nielsen, M. A. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90166-1 · Cited by 182 · see citing works
Self-citationYoung, W. S., Alheid, G., & Heimer, L. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-06-01626.1984 · Cited by 179 · see citing works
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Self-citationMogenson, G. J., Swanson, L. W., & Wu, M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90568-2 · Cited by 167 · see citing works
Self-citationNucleus accumbens to globus pallidus GABA projection subserving ambulatory activity
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Self-citationSwanson, L. W., Mogenson, G. J., Simerly, R. B., & Wu, M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90995-4 · Cited by 112 · see citing works
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Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Translational principles of deep brain stimulation
Kringelbach, M. L., Jenkinson, N., Owen, S. L. F., & Aziz, T. Z. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2196 · Cited by 853 · see citing works
- Authors
- Mogenson, G. J., & Wu, M.
- Affiliations
- Western University (CA)
- ORCID
- Wu, Michael
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1988-02
- Volume
- 20
- Issue
- 2
- Pages
- 241-246
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2010975813
- Cited by
- 50
- References
- 21
- Citations by year
- 2026: 1 · 2019: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- locomotor activity, mediodorsal thalamus, pedunculopontine nucleus, procaine, picrotoxin, mesencephalic locomotor region, limbic system, adaptive behavior
- MeSH terms
- Animals, Globus Pallidus, Injections, Mesencephalon, Motor Activity, Picrotoxin, Pons, Procaine, Substantia Innominata, Thalamus
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