Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

Pijnenburg, A. J. J.; Honig, W. M. M.; Van Rossum, J. M.

doi:10.1007/bf00421062

Cited by 330Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchSchizophrenia research and treatment

Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

Pijnenburg, A. J. J., Honig, W. M. M., Van Rossum, J. M.·1975·Psychopharmacologia

DOI 10.1007/bf00421062

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Abstract

The effect of intracerebral administraton of antagonists of dopamine and noradrenaline upon the locomotor stimulation induced by intraperitoneal injection of d-amphetamine sulfate in rats was investigated. Inj ection of low doses of the dopamine antagonist haloperidol (2.5 mug and 5 mug) bilaterally into the nucleus accumbens antagonized the locomotor stimulation following d-amphetamine. No significant inhibition was observed following administration of the alpha-adrenergic antagonist phentolamine or thhe beta-adrenergic antagonist propranolol into the nucleus accumbens. Injection of the dame doses of haloperidol into the caudate nucleus did not inhibit the d-amphetamine induced locomotor activity in contrast to the effects seen following injection into the nucleus accumbens. The results confirm the significance of dopaminergic mechanisms for the locomotor stimulant effect of d-amphetamine and indicate that the mesolimbic dopamine system plays an important role in this respect.

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Both novelty-induced locomotor activity and the hyperactivity evoked by amphetamine depend on nucleus accumbens dopamine neurotransmission.
“Given that both novelty-induced locomotor activity (Hooks and Kalivas 1994) and the hyperactivity evoked by amphetamine depend on nucleus accumbens dopamine neurotransmission (Creese and Iversen 1975; Pijnenburg et al. 1975)”
From Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia (2025) · cites this paper as Pijnenburg et al. 1975

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Authors: Pijnenburg, A. J. J., Honig, W. M. M., & Van Rossum, J. M.
Affiliations: Radboud University Nijmegen (NL)
Venue: Psychopharmacologia
Publisher: Springer Science and Business Media LLC
Published: 1975-01
Volume: 41
Issue: 2
Pages: 87-95
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/bf00421062
OpenAlex: W2056553920
Cited by: 330
References: 50
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 3
FWCI: 5.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: d-amphetamine, locomotor activity, haloperidol, nucleus accumbens, dopamine antagonism, mesolimbic dopamine system, caudate nucleus, phentolamine, propranolol, alpha-blockers, beta-blockers, stimulant effects
MeSH terms: Animals, Caudate Nucleus, Depression, Chemical, Dextroamphetamine, Haloperidol, Injections, Male, Motor Activity, Norepinephrine, Olfactory Bulb, Phentolamine, Propranolol, Stereotaxic Techniques, Time Factors, Dopamine Antagonists, Rats

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Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

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