Prolactin and thyrotropin pituitary response to thyrotropin releasing hormone in young female heroin addicts
Abstract
Prolactin (PRL) and thyrotropin (TSH) serum levels were determined in a group of young female heroin addicts treated in hospital with methadone in tapered doses. At admission, from 24 to 3 h after the last dose of 'street' heroin, basal PRL values were 21 +/- 2.6 ng/ml, i.e. significantly higher (P less than 0.001) than in controls: 9.8 +/- 0.7; there was no significant differences of basal TSH values between heroin addicts and normal subjects: 2.5 +/- 0.2 vs. 2.2 +/- 0.1 mu units/ml, respectively. The day after admission, when methadone treatment was begun, the PRL and TSH pituitary response to thyrotropin releasing hormone (TRH) 200 micrograms i.v. in 12 patients was studied. The PRL response was significantly reduced (P less than 0.001) in heroin addicts vs. controls, the mean values of highest percent increments over basal were 368 +/- 41.8 and 847 +/- 80.7, respectively. The TSH response in the two groups was similar, the mean highest per cent increment over basal 393 +/- 53.4 in heroin addicts vs. 367 +/- 39.2 in controls. The increase of the PRL basal concentration and its decreased pituitary response following TRH were probably related to a change in the tuberoinfundibolar dopaminergic system (TIDA) because of a chronic intake of opiates whereas the impaired function of the dopaminergic system did not alter the thyrotropin pituitary secretion.
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Basal TSH values have been reported to be lower, unaffected, or increased in chronic opioid users.
“Furthermore, basal TSH values have been reported to be lower (149, 153), unaffected (74, 116, 136, 155-160), or increased (118, 161).”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [157]
Studies with dynamic thyrotropin-releasing hormone test performed in chronic opioid users have demonstrated conflicting results with enhanced, blunted, or no TSH response.
“Studies with dynamic thyrotropin-releasing hormone test performed in chronic opioid users have demonstrated conflicting results with enhanced (118), blunted (136, 155, 156), or no (74, 157) TSH response.”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [157]
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- Authors
- Spagnolli, W.
- Corresponding author
- Spagnolli, W
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 1987-11-30
- Volume
- 20
- Issue
- 3
- Pages
- 247-254
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W2037804323
- Cited by
- 10
- References
- 15
- Citations by year
- 2024: 1 · 2023: 1 · 2019: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- prolactin, thyroid-stimulating hormone, thyrotropin-releasing hormone, pituitary responsiveness, heroin addiction, methadone maintenance treatment, dopaminergic dysfunction, hypothalamic-pituitary-thyroid axis
- MeSH terms
- Adolescent, Adult, Female, Heroin Dependence, Humans, Menstruation Disturbances, Prolactin, Thyrotropin, Thyrotropin-Releasing Hormone
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