Effects of chronic methadone administration on the hypothalamic-pituitary-thyroid axis
Abstract
Pituitary and thyroidal response to the iv administration of thyrotropin releasing hormone was assessed in 8 subjects on chronic methadone therapy. All subjects showed a normal rise of thyrotropin and triiodothyronine, suggesting that the hypothalamic-pituitary-thyroidal axis is intact.
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Variable results have also been described for peripheral thyroid hormones; T4 levels were unaffected or decreased and T3 levels were increased, unaffected, or decreased.
“Variable results have also been described for the peripheral thyroid hormones; T4 levels were unaffected (74, 118, 136, 159, 160) or decreased (116, 160-162) and T3 levels were increased (74, 159) or unaffected (160) or decreased (161).”
From Exogenous Opioids and the Human Endocrine System: An Endocrine Society Scientific Statement (2024) · cites this paper as [160]
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Self-citationThe Stimulation of Albumin Synthesis by Methadone
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- Authors
- SHENKMAN, L., MASSIE, B., MITSUMA, T., & HOLLANDER, C. S.
- Affiliations
- NYU Langone Health (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1972-07
- Volume
- 35
- Issue
- 1
- Pages
- 169-170
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2109806056
- Cited by
- 28
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2018: 1 · 2014: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- methadone, hypothalamic-pituitary-thyroid axis, thyroid-stimulating hormone, triiodothyronine, pituitary responsiveness, thyroid function, long-term opioid therapy
- MeSH terms
- Adult, Heroin, Female, Humans, Hypothalamus, Injections, Intravenous, Male, Methadone, Middle Aged, Pituitary Gland, Radioimmunoassay, Thyroid Gland, Thyrotropin, Thyrotropin-Releasing Hormone, Time Factors, Triiodothyronine, Substance-Related Disorders
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