Severity of abruptio placentae and neurodevelopmental outcome in low birth weight infants
Abstract
The short term neonatal morbidity and 2-year neurodevelopmental outcome were evaluated in 40 low birthweight (< 2500 g) liveborn infants delivered after abruptio placentae and in 80 control infants of similar gestational age. Apgar scores at 1' and 5' were lower in infants born to mothers with severe abruption. The prevalence of intraventricular hemorrhage (Grades I-IV) was 17.5% (7/40) in the cases and 5% (4/80) in the controls (P = 0.035). Cystic periventricular leukomalacia was diagnosed in two cases (5%) and in none of the controls (P = 0.1). At 2-year follow-up, among surviving infants, cerebral palsy (spastic diplegia, hemiplegia or tetraplegia with or without mental retardation) was diagnosed in 11.1% (4/36) of the cases and in none of the 76 controls (P = 0.011). After adjustment by logistic regression analysis for the effect of confounders (gestational age, birthweight, social class and duration of mother's education) the odds ratio of a poor outcome defined as neonatal death or cerebral palsy was 4.4 (95% confidence interval, 1.2-17.0) in index cases as a whole and 8.0 (95% confidence interval, 1.5 to 43.0) in the subgroup of infants born after severe abruption. Mild abruption did not affect the 2-year infant outcome in both univariate and multivariate analysis.
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Abruption is associated with a 2- to 4-fold increased risk of developmental disorders in infants born of abruption pregnancies.
“Abruption is associated with 6 to 10-fold increased risk of cerebral palsy and 2 to 4-fold increased risk of developmental disorders in infants born of abruption pregnancies (62, 118–121).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [118]
Neonates exposed to abruption, particularly those complicating pregnancies at preterm gestations, are at increased risk for cystic periventricular leukomalacia.
“Neonates exposed to abruption, particularly those that complicate pregnancies at preterm gestations, are at increased risk for cystic periventricular leukomalacia and intraventricular hemorrhage (117, 118).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [118]
Abruption is associated with a 6- to 10-fold increased risk of cerebral palsy in infants born of abruption pregnancies.
“Abruption is associated with 6 to 10-fold increased risk of cerebral palsy and 2 to 4-fold increased risk of developmental disorders in infants born of abruption pregnancies (62, 118–121).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [118]
Neonates exposed to abruption, particularly those complicating pregnancies at preterm gestations, are at increased risk for intraventricular hemorrhage.
“Neonates exposed to abruption, particularly those that complicate pregnancies at preterm gestations, are at increased risk for cystic periventricular leukomalacia and intraventricular hemorrhage (117, 118).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [118]
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- Authors
- Spinillo, A., Fazzi, E., Stronati, M., Ometto, A., Iasci, A., & Guaschino, S.
- Affiliations
- Policlinico San Matteo Fondazione (IT)
- University of Pavia (IT)
- Corresponding author
- Spinillo, Arsenio
- Venue
- Early Human Development
- Publisher
- Elsevier BV
- Published
- 1993-11
- Volume
- 35
- Issue
- 1
- Pages
- 45-54
- ISSN
- 0378-3782 (ISSN-L)
- OpenAlex
- W2078023313
- Cited by
- 51
- References
- 25
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2012: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Early Human Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- placental abruption, low birth weight infants, neurodevelopmental outcomes, cerebral palsy, intraventricular hemorrhage, periventricular leukomalacia, neonatal morbidity, Apgar score, neonatal death
- MeSH terms
- Abruptio Placentae, Adult, Apgar Score, Cerebral Hemorrhage, Cerebral Palsy, Female, Gestational Age, Heart Rate, Fetal, Humans, Infant Mortality, Infant, Low Birth Weight, Infant, Newborn, Nervous System, Pregnancy
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